Early treatment with UR13870, a novel inhibitor of p38α mitogenous activated protein kinase, prevents hyperreflexia and anxiety behaviors, in the spared nerve injury model of neuropathic pain

Galán-Arriero, Iriana; Ávila-Martín, Gerardo; Ferrer-Donato, Águeda; Gómez-Soriano, Julio; Piazza, Stefano; Taylor, Julian

doi:10.1016/j.neulet.2015.07.044

Cited by 12 publications

(11 citation statements)

References 25 publications

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“…A previous study reported that jct-801 relieves paclitaxel-induced neuropathic pain through the PI3K/Akt pathway (34). Our study suggested that differentially expressed mRNAs are involved in NP possibly through regulating the MAPK signaling pathway, which is consistent with a previous study (35). The Cyclic Adenosine Monophosphate (cAMP) signaling pathway is a key contributor to the development of chronic pain, and an existing study indicated that knockdown of the cAMP effector can relieve the painlike responses in chronic pain models (36).…”

Section: Discussionsupporting

confidence: 92%

Bioinformatics analysis of the regulatory lncRNA-miRNA-mRNA network in patients with neuropathic pain and prediction of potential therapeutics

Zhang¹,

Liu²,

Song³

et al. 2020

Preprint

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Background: Neuropathic pain (NP) is the main form of chronic pain, caused by damage to the nervous system and dysfunction. Here, we aimed at exploring the key molecules involved in NP pathogenesis via the identification of its regulatory lncRNA-miRNA-mRNA network.Methods: We downloaded NP-related data from public databases and identified differentially expressed long noncoding RNAs (lncRNAs), microRNAs (miRNAs) and mRNAs through differential gene expression analysis. The lncRNA and miRNA target predictions were performed and an integration of the three datasets was used for construction of the lncRNA-miRNA-mRNA network. Subsequently, functional enrichment analysis and protein-protein interaction (PPI) analysis were performed to explore the role and the interactions of the mRNAs. The drug prediction was performed based on the mRNAs in the lncRNA-miRNA-mRNA network. Results: A total of 8,251 differentially expressed mRNAs (4,193 upregulated and 4,058 downregulated), 959 differentially expressed miRNAs (455 upregulated and 504 downregulated), 2,848 differentially expressed lncRNAs (1,324 upregulated and 1,524 downregulated) were identified by integrating the results of the three microarray datasets. We found that differentially expressed mRNAs were mainly enriched in blood circulation, metal ion transmembrane transporter activity, and synaptic membrane. The most significant pathway of mRNAs in lncRNA-miRNA-mRNA network were GTPase, cell cycle, and platelet activation. A total of 1,200 drugs were predicted as potential therapeutics for NP based on the regulatory genes.Conclusion: Our study predicted drugs that may be effective for NP based on the NP regulatory network. This information will help further reveal the pathological mechanism of NP and provide more treatment options for NP patients.

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Section: Discussionsupporting

confidence: 92%

Bioinformatics analysis of the regulatory lncRNA-miRNA-mRNA network in patients with neuropathic pain and prediction of potential therapeutics

Zhang¹,

Liu²,

Song³

et al. 2020

Preprint

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“…The reason why huge variability is frequently observed with this test can also be due to the protocol parameters, such as light setting (from 4 to more than 100 lux), test duration (4–60 min), area size and definition of the central zone. Indeed, over the 18 studies for which light parameters are provided in methods, 10 out of the 14 studies conducted with a light intensity set at 60 lux or less succeeded in demonstrating pain‐induced anxiety‐like behaviours (Avila‐Martin et al, 2015; Galan‐Arriero et al, 2015; Gong et al, 2018; Hasnie, Breuer, et al, 2007; Missig et al, 2017; Suzuki et al, 2007; Wallace, Blackbeard, Pheby, et al, 2007; Wallace, Blackbeard, Segerdahl, et al, 2007; Wallace, Segerdahl, et al, 2007; Zhang, Jiang, & Gao, 2017), while the four studies using an intensity equal or higher than 100 lux failed (Chen, Wei, Pertovaara, Wang, & Carlson, 2018; Kodama et al, 2011; Kontinen et al, 1999; Urban et al, 2011). These data suggest that too high light intensity might induce anxiety strong enough in controls to mask the difference between experimental groups and that milder light setting should perhaps be preferred for better discrimination between groups.…”

Section: Evaluating Anxiety‐like and Depression‐like Behaviours In Anmentioning

confidence: 99%

How to study anxiety and depression in rodent models of chronic pain?

Kremer

Becker

Barrot

et al. 2020

Eur J of Neuroscience

100

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“…p38 kinases are involved in nociception (Crown et al, 2008) and neuropathic pain (Svensson et al, 2003;Svensson et al, 2005) (Figure 5B). Antinociceptive action was found in animal models of pain for p38α inhibitors (Sweitzer et al, 2004;Galan-Arriero et al, 2015). Mechanism of action of p38α in nociception are based on regulation of nociceptive channels.…”

Section: Painmentioning

confidence: 99%

Functions of p38 MAP Kinases in the Central Nervous System

Asih

Prikas

Stefanoska

et al. 2020

Front. Mol. Neurosci.

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Mitogen-activated protein (MAP) kinases are a central component in signaling networks in a multitude of mammalian cell types. This review covers recent advances on specific functions of p38 MAP kinases in cells of the central nervous system. Unique and specific functions of the four mammalian p38 kinases are found in all major cell types in the brain. Mechanisms of p38 activation and downstream phosphorylation substrates in these different contexts are outlined and how they contribute to functions of p38 in physiological and under disease conditions. Results in different model organisms demonstrated that p38 kinases are involved in cognitive functions, including functions related to anxiety, addiction behavior, neurotoxicity, neurodegeneration, and decision making. Finally, the role of p38 kinases in psychiatric and neurological conditions and the current progress on therapeutic inhibitors targeting p38 kinases are covered and implicate p38 kinases in a multitude of CNS-related physiological and disease states.

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Early treatment with UR13870, a novel inhibitor of p38α mitogenous activated protein kinase, prevents hyperreflexia and anxiety behaviors, in the spared nerve injury model of neuropathic pain

Cited by 12 publications

References 25 publications

Bioinformatics analysis of the regulatory lncRNA-miRNA-mRNA network in patients with neuropathic pain and prediction of potential therapeutics

Bioinformatics analysis of the regulatory lncRNA-miRNA-mRNA network in patients with neuropathic pain and prediction of potential therapeutics

How to study anxiety and depression in rodent models of chronic pain?

Functions of p38 MAP Kinases in the Central Nervous System

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