Early Trauma and Cognitive Functions of Patients With Schizophrenia

Carrilho, Carolina Gomes; Cougo, Simone S.; Bombassaro, Tatiane; Varella, André A. B.; Alves, Gilberto Sousa; Machado, Sérgio; Murillo-Rodrı́guez, Eric; Malaspina, Dolores; Nardi, Antônio Egídio; Veras, André Barciela

doi:10.3389/fpsyt.2019.00261

Cited by 5 publications

(4 citation statements)

References 22 publications

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“…SCZ is a multifactorial brain disorder that can manifest as a range of symptoms, including cognitive, behavioral, and emotional deficits with delusions, hallucinations, or disorganized thinking (Tandon et al ; Lally et al ; Carrilho et al ). Similar to MDD, research data back to the early 1970s established differences in CSF DβH activity in SCZ patients (Dunner et al ; Wise and Stein ).…”

Section: Neuropsychiatric Issues and Dβhmentioning

confidence: 99%

Dopamine beta‐hydroxylase and its genetic variants in human health and disease

Gonzalez-Lopez

Vrana

2019

Journal of Neurochemistry

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Dopamine beta-hydroxylase (DbH) is an essential neurotransmitter-synthesizing enzyme that catalyzes the formation of norepinephrine (NE) from dopamine and has been extensively studied since its discovery in the 1950s. NE serves as a neurotransmitter in both the central and peripheral nervous systems and is the precursor to epinephrine synthesis in the brain and adrenal medulla. Alterations in noradrenergic signaling have been linked to both central nervous system and peripheral pathologies. DbH protein, which is found in circulation, can, therefore, be evaluated as a marker of norepinephrine function in a plethora of different disorders and diseases. In many of these diseases, DbH protein availability and activity are believed to contribute to disease presentation or select symptomology and are believed to be under strong genetic control. Alteration in the DbH protein by genetic polymorphisms may result in DbH becoming ratelimiting and directly contributing to lower NE and epinephrine levels and disease. With the completion of the human genome project and the advent of next-generation sequencing, new insights have been gained into the existence of naturally occurring DbH sequencing variants (genetic polymorphisms) in disease. Also, biophysical tools coupled with genetic sequences are illuminating structure-function relationships within the enzyme. In this review, we discuss the role of genetic variants in DbH and its role in health and disease.

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Section: Neuropsychiatric Issues and Dβhmentioning

confidence: 99%

Dopamine beta‐hydroxylase and its genetic variants in human health and disease

Gonzalez-Lopez

Vrana

2019

Journal of Neurochemistry

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“…Child abuse has been linked to physical, social, cognitive and psychological problems in adulthood (McNeal and Amato, 1998;Adams, 2006;Adhia et al, 2019). Substantial evidence has shown that violence against children is positively associated with their suffering from posttraumatic stress disorder, depression, anxiety and low levels of selfesteem and self-efficacy (Carrilho et al, 2019;Haj-Yahia et al, 2019).…”

Section: Consequences Of Child Maltreatmentmentioning

confidence: 99%

Prevalence of Child Maltreatment during the COVID-19 Pandemic: A Cross-sectional Survey of Rural Hubei, China

Zhang

Shi

et al. 2021

The British Journal of Social Work

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The impact of lockdown measures in Wuhan, China during the coronavirus disease 2019 pandemic on child maltreatment remains unknown. The present study attempted to estimate the prevalence of child maltreatment during this period, to identify risk factors, and the influence of child maltreatment. A representative sample of 1,062 school-aged children in rural Hubei province was surveyed. Results indicated that the prevalence of family violence, physical violence, emotional abuse and neglect during the lockdown period were 13.9, 13.7, 20.2 and 7.3 percent, respectively, and that of lifetime prevalence were 17.0, 13.9, 14.6 and 6.9 percent, respectively. And most victims did not seek official help. Boys were more likely to experience physical violence. Children from separated/divorced families tended to report more emotional abuse. Those having family members with a history of drug abuse and mental illness were more likely to experience neglect during the lockdown period. All types of child maltreatment were positively associated with self-harm behaviours. These findings highlight the importance of identifying at-risk children immediately and implementing timely intervention programmes to prevent self-harm behaviours for social workers and health professionals.

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“…Cognitive impairment is highly prevalent in schizophrenia, possibly because both psychotic symptoms and impaired cognition share similar etiology – genetic and/or environmental features [ 31 ]. Accordingly, physical or emotional trauma during childhood may cause cognitive impairment and increase the risk of developing schizophrenia or other mental disorders later in life [ 32 ]. Childhood maltreatment and neglect are known to have a detrimental impact on the cognitive functioning of patients with schizophrenia and bipolar disorder [ 33 ].…”

Section: Introductionmentioning

confidence: 99%

Exploring the association between lifetime traumatic experiences and positive psychotic symptoms in a group of long-stay patients with schizophrenia: the mediating effect of depression, anxiety, and distress

Rahme¹,

Kadri

Haddad

et al. 2023

BMC Psychiatry

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Background Positive psychotic symptoms of schizophrenia are generally characterized by hallucinations and delusions. We propose to assess the relationship between total composite trauma and positive psychotic symptoms, along with the mediation effect of cognition, fear of COVID-19, insomnia, anxiety, distress, and depression of Lebanese patients with schizophrenia. Methods A cross-sectional study was carried out, between June and July 2021, by deriving data from 155 long-stay in-patients diagnosed with schizophrenia. Results Depression, anxiety, and distress but not cognitive impairment, insomnia, and fear of COVID-19) mediated the association between lifetime traumatic experiences and positive psychotic symptoms. Higher traumatic experiences were associated with greater depression, anxiety, and distress, indicating a significant positive total effect on positive psychotic scores. Moreover, higher depression, anxiety, and distress were significantly associated with higher positive psychotic symptoms. Conclusion Our results contribute to the existing knowledge by suggesting other possible intervention paths through mediating factors. Interventions that improve anxiety, depression, and distress severity may be effective in reducing positive psychotic symptoms among patients with schizophrenia having experienced lifetime trauma.

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Early Trauma and Cognitive Functions of Patients With Schizophrenia

Cited by 5 publications

References 22 publications

Dopamine beta‐hydroxylase and its genetic variants in human health and disease

Dopamine beta‐hydroxylase and its genetic variants in human health and disease

Prevalence of Child Maltreatment during the COVID-19 Pandemic: A Cross-sectional Survey of Rural Hubei, China

Exploring the association between lifetime traumatic experiences and positive psychotic symptoms in a group of long-stay patients with schizophrenia: the mediating effect of depression, anxiety, and distress

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