“…
Treatment delayed beyond 3 days is an independent factor indicating a poor prognosis (OR 10.75, 95 % CI 1.02-113.39, p = 0.048) Khamnuan P et al [ 50 ] | 2015/Thailand | Retrospective/2009 to 2012 | n = 290/1504 (19.3 %) | Female gender; age >60; chronic heart disease, cirrhosis, skin necrosis, pulse rate >130/min, systolic BP <90 mmHg, and serum creatinine ≥1.6 mg/dL |
Khamnuan P et al [ 51 ] | 2015/Thailand | Retrospective observational cohort study/2009 to 2012 | 165 (69.6) in patients with severe sepsis ( n = 237) 66 (5.5) without severe sepsis ( n = 1,215) P <0.001 | Female sex, diabetes mellitus, chronic heart disease, hemorrhagic bleb, skin necrosis, and serum protein <6 g/dL |
Arif et al [ 52 ] | 2016/USA | Retrospective/2003 to 2013 | 9871 NF-related deaths 4 · 8 deaths/ 1000000 person-yr | Diabetes mellitus, obesity, and renal failure were significantly associated with NF-related death. However, age, sex, and race were independently associated with the rate of NF-related deaths |
Hadeed GJ et al [ 35 ] | 2016/USA | Retrospective/2003 to 2008 | 11/87 (12.5 %) | Clinically significant difference based on the timing of surgical intervention (< or > 6 h) (17.5 % in late vs. 7.5 % in early intervention group), however no statistical significance |
a = Deaths/total NF cases …”