Early steps of insulin receptor signaling in chicken and rat: apparent refractoriness in chicken muscle

Dupont, Joëlle; Dagou, Carine; Derouet, Michel; Simon, Jean; Taouis, Mohammed

doi:10.1016/j.domaniend.2003.09.004

Cited by 69 publications

(55 citation statements)

References 40 publications

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“…This difference between species could be related to the peculiarities of chicken glucose metabolism. In spite of having 'normal' levels of circulating insulin, chickens have high glycaemia levels and show lower sensitivity to exogenous insulin as compared to humans (Simon 1989, Akiba et al 1999, Dupont et al 2004, Braun & Sweazea 2008. The inhibitory effect of NAMPT on IGF1-induced progesterone production is dependent on the intracellular enzymatic activity of NAMPT as it is abolished by the pharmacological competitive inhibitor FK866 (10 nM).…”

Section: Discussionmentioning

confidence: 99%

Expression and effect of NAMPT (visfatin) on progesterone secretion in hen granulosa cells

Diot¹,

Reverchon²,

Ramé³

et al. 2015

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In mammals, nicotinamide phosphoribosyltransferase (NAMPT) is an adipokine produced by adipose tissue that is found in intracellular and extracellular compartments. The intracellular form of NAMPT is a nicotinamide phosphoribosyltransferase, whereas the extracellular form is considered an adipokine. In humans, NAMPT regulates energy metabolism and reproductive functions, such as ovarian steroidogenesis. To date, no study has investigated the role of NAMPT in hen ovaries. We investigated whether NAMPT is present in hen ovarian follicles and its role in granulosa cells. Using RT-PCR, western blotting and immunocytochemistry, we detected mRNA transcripts and proteins related to NAMPT in theca and granulosa cells from pre-ovulatory follicles. Using RT-PCR, we demonstrated that mRNA NAMPT levels were higher in granulosa cells than they were in theca cells and that during follicle development, theca cell levels decreased, whereas levels remained unchanged in granulosa cells. NAMPT protein quantities were significantly higher in theca cells than they were in granulosa cells, but they were unchanged during follicular development. Plasma NAMPT levels, as determined by ELISA and immunoblotting, were significantly lower in adult hens than they were in juveniles. In vitro, treatment with human recombinant NAMPT (100 ng/ml, 48 h) halved basal and IGF1-induced progesterone secretion, and this was associated with a reduction in STAR and HSD3B protein levels and MAPK3/1 phosphorylation levels in granulosa cells. These effects were abolished by the addition of FK866, a specific inhibitor of NAMPT enzymatic activity. Moreover, NAMPT had no effect on granulosa cell proliferation. In conclusion, NAMPT is present in hen ovarian cells and inhibits progesterone production in granulosa cells.

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Section: Discussionmentioning

confidence: 99%

Expression and effect of NAMPT (visfatin) on progesterone secretion in hen granulosa cells

Diot¹,

Reverchon²,

Ramé³

et al. 2015

Reproduction

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“…It is quite possible that the same and still-unidentified steps that prevent nutrients to be insulinotropic in chicken endocrine pancreas (188) also prevent GKA being insulinotropic in this species. Dupont et al (189) showed that the high basal glycaemia of avian species does not result from insulin resistance at the hepatic level, as observed in chickens. It can thus be …”

Section: Glucokinase-regulatory Protein In Chickensmentioning

confidence: 99%

Nutritional regulation of glucokinase: a cross-species story

Panserat

Rideau²,

Polakof

2014

Nutr. Res. Rev.

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The glucokinase (GK) enzyme (EC 2.7.1.1.) is essential for the use of dietary glucose because it is the first enzyme to phosphorylate glucose in excess in different key tissues such as the pancreas and liver. The objective of the present review is not to fully describe the biochemical characteristics and the genetics of this enzyme but to detail its nutritional regulation in different vertebrates from fish to human. Indeed, the present review will describe the existence of the GK enzyme in different animal species that have naturally different levels of carbohydrate in their diets. Thus, some studies have been performed to analyse the nutritional regulation of the GK enzyme in humans and rodents (having high levels of dietary carbohydrates in their diets), in the chicken (moderate level of carbohydrates in its diet) and rainbow trout (no carbohydrate intake in its diet). All these data illustrate the nutritional importance of the GK enzyme irrespective of feeding habits, even in animals known to poorly use dietary carbohydrates (carnivorous species).

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“…우 낮은 glycogen 수준 및 혈중 인슐린의 낮은 수준에 의한 혈중 포도당 농도 조절 미약 (Dupont et al, 2004) 등과 같이 포유동물과 차별화된 조류 특유의 포도당 대사를 갖고 있 다. 조류의 간은 절식하게 되면 간의 glycogen 함량을 낮추 어, 혈중 포도당의 수준을 조절하여 포도당 항상성 유지에 기여하게 된다 (Tinker et al, 1986).…”

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Effects of Lycopene on the Expression of Lipid Metabolism, Glucose Transport and Pro-Inflammatory Related Genes in Chickens

Jang¹,

Moon

2015

Korean Journal of Poultry Science

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The present study aimed to investigate the effects of lycopene on hepatic metabolic-and immune-related gene expression in laying hens. A total of 48 25-week-old White Leghorn hens were randomly allocated into four groups consisting of four replicates of three birds: control (basal diet), T1 (basal diet + 10 mg/kg of tomato powder-containing lycopene), T2 (basal diet + 10 mg/kg of micelles of tomato powder-containing lycopene), and T3 (basal diet + 10 mg/kg of purified lycopene). Chickens were fed ad libitum for 5 weeks, and then total RNA was extracted from the livers for quantitative RT-PCR analysis. Peroxisome proliferator-activated receptor ɣ (PPARɣ) expression was decreased in the liver of chickens after lycopene supplementation (P<0.05). Micellar lycopene supplementation decreased the expression of PPARɣ target genes including fatty acid binding protein 4 (FABP4) and fatty acids synthase (FASN) in the T2 group (P<0.05). Sterol regulatory element-binding protein 2 (SREBP2) and C/EBP-ɑ were also downregulated in hens fed with micellar lycopene (P<0.05). Glucose transporter 8 (GLUT-8) was upregulated in the T2 and T3 groups (P<0.05). However, the expression of carnitine palmitoyltransferase 1 (CPT-1) was not changed by lycopene supplementation. Pro-inflammatory cytokines such as tumor necrosis factor ɑ (TNF-ɑ) and interleukin 6 (IL-6) were downregulated by lycopene supplementation (P<0.05). These data suggest that the type of lycopene supplementation is critical and that micelles of tomato powder-containing lycopene may play an important role in the modulation of lipid metabolism and immunity in chickens.

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Early steps of insulin receptor signaling in chicken and rat: apparent refractoriness in chicken muscle

Cited by 69 publications

References 40 publications

Expression and effect of NAMPT (visfatin) on progesterone secretion in hen granulosa cells

Expression and effect of NAMPT (visfatin) on progesterone secretion in hen granulosa cells

Nutritional regulation of glucokinase: a cross-species story

Effects of Lycopene on the Expression of Lipid Metabolism, Glucose Transport and Pro-Inflammatory Related Genes in Chickens

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