Early-Stage Young Breast Cancer Patients: Impact of Local Treatment on Survival

Bantema-Joppe, Enja J.; Munck, Linda de; Visser, Otto; Willemse, Pax H.B.; Langendijk, Johannes A.; Siesling, Sabine; Maduro, John H.

doi:10.1016/j.ijrobp.2011.02.060

Cited by 52 publications

(26 citation statements)

References 32 publications

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“…Six randomized controlled trials comparing mastectomy and BCT all included a low proportion of young breast cancer patients (12-23%) [44], making it hard to draw any conclusion for this subgroup. Few cohort studies restricted to young breast cancer patients have been published [2,[45][46][47][48][49], and they are limited by the inclusion of a mixture of different TNM stages, by the variety of adjuvant systemic treatments offered, and by a median follow-up time of less than 10 years. In contrast, the present study is based on an unbiased cohort (comprising almost all lymph node negative patients below 41 years treated in Denmark in the 1989-1998 period) with complete registration of incident breast cancer and complete follow-up data on LRR and mortality within 20 years.…”

Section: Discussionmentioning

confidence: 99%

Impact of age, intrinsic subtype and local treatment on long-term local-regional recurrence and breast cancer mortality among low-risk breast cancer patients

et al. 2016

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Section: Discussionmentioning

confidence: 99%

Impact of age, intrinsic subtype and local treatment on long-term local-regional recurrence and breast cancer mortality among low-risk breast cancer patients

et al. 2016

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“…24 Amerika Birleşik Devletleri'nden Nissen ve ark. tarafın-dan yayınlanan ve MKC, MRM ve MRM sonrası rekonstrüksiyon (MRM-RK) uygulanan hastaları içeren çalışmada, MKC ve MRM-RK gruplarının beden imajı açısından MRM'ye üstün olduğu göste-rilmiştir.…”

Section: Kaynaklarunclassified

Clinical and Histopathologic Characteristics of Breast Cancer Cases Aged 35 Years and Younger

Soyder¹,

Özbaş²,

Koçak³

2013

Turkiye Klinikleri J Med Sci

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Ö ÖZ ZE ET T A Am ma aç ç: : Meme kanserinin genç hastalarda daha agresif seyrettiği, daha yüksek mortalite ve nüks oranına sahip olduğu öne sürülmektedir. Çalışmamızda, meme kanseri tanısı ile tedavi ve takip edilen 35 yaş ve altındaki olguların tanı anındaki klinik ve histopatolojik özellikleri ile uygulanan tedavilerin ve takip sonuçlarının değerlendirilmesi hedeflendi. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Çalışmaya iki ayrı merkezde Haziran 2004-Temmuz 2011 tarihleri arasında meme kanseri tanısı nedeniyle ameliyat edilen toplam 522 hastadan, tanı anında 35 yaş ve altında olan 88 olgu dâhil edildi. Hastalara ait klinik ve histopatolojik özellikler, uygulanan tedaviler ve takip sonuçları geriye dönük olarak incelendi ve elde edilen veriler tanımlayıcı olgu serisi şeklinde raporlandı. B Bu ul lg gu ul la ar r: : Otuz beş yaş ve altındaki olgular tüm meme kanserli olgularımızın %16,9'unu oluşturmaktaydı. Olguların 58'inin (%65,9) tanı sırasında Evre 0, I ve II olduğu, 67'sinde (%76,1) lenfovasküler invazyon bulunduğu ve 46'sında (%52,2) tümörün derece 2 olduğu görüldü. Olguların 51'inde (%57,9) östrojen reseptörü pozitif ve 33'ünde (%37,5) progesteron reseptörü pozitif saptandı. CerbB-2 29 (%32,9) olguda pozitifti. Elli iki (%59,1) olguda aksiller lenf düğümü tutulumu saptandı. Otuz sekiz (%43,2) olguya meme koruyucu cerrahi ve 50 (%56,8) olguya mastektomi uygulandı. Mastektomiden sonra olguların 23'ünde (%46) eş zamanlı meme rekonstrüksiyonu tercih edildi. Toplam 26,9 ± 18,77 (11-72) aylık takipte 2 (%2,3) olguda meme kanserine özgül mortalite görülürken, lokal nüks izlenmedi. S So on nu uç ç: : Otuz beş yaş ve altındaki meme kanserli olgu grubunda kötü prognostik özelliklerin yüksek oranda bulunduğu dikkati çekmektedir. Bunun yanında, hastalıksız sağkalım oranının yüksek ve lokal nüks oranlarının düşük olması sevindiricidir. Ayrıca, genç yaşta meme kanseri ortaya çıkan, kadınlarda mastektomi gerektiren durumlarda, eş zamanlı meme rekonstrüksiyonu uygulamasının mutlaka değerlendirilmesi gerektiği görüşündeyiz.A An na ah ht ta ar r K Ke el li im me el le er r: : Meme tümörleri; genç erişkin; prognoz; sağkalım A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : Breast cancer is reported to progress more aggressively and to have a higher mortality and relapse rate in younger patients. In this study, clinical and histopathologic characteristics and treatment options will be assessed in breast cancers in patients 35 years and younger. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : The study included 88 cases aged 35 years and younger out of 522 cases operated with for breast cancer between June 2004 and July 2011. Clinical and histopathologic characteristics, treatment modalities and follow-up results were analyzed retrospectively. R Re es su ul lt ts s: : Cases aged 35 years and younger accounted for 16.9% of all breast cancer cases. By the time of diagnosis 58 (65.9%) cases were Stage 0, I and II, 67 (76.1%) had lymphovascular invasion and 46 (52.2%) had Grade 2 tumor. Estrogen re...

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“…In recent years, several large retrospective analyses of contemporary data have suggested the stage‐adjusted superiority of BCS over mastectomy in early breast cancer in terms of breast cancer‐specific survival and overall survival. Other publications have focused on young women or triple‐negative breast cancer, with the results indicating that BCS is at least as good as mastectomy in terms of survival outcomes. This interesting finding has led some authors to question whether mastectomy without RT should be offered at all as a treatment alternative for early breast cancer, or whether it is time to abandon the ‘mastectomy myth’.…”

Section: Introductionmentioning

confidence: 99%

Breast-conserving surgery followed by whole-breast irradiation offers survival benefits over mastectomy without irradiation

Boniface

Frisell

Bergkvist

et al. 2018

British Journal of Surgery

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BackgroundThe prognostic equivalence between mastectomy and breast‐conserving surgery (BCS) followed by radiotherapy was shown in pivotal trials conducted decades ago. Since then, detection and treatment of breast cancer have improved substantially and recent retrospective analyses point towards a survival benefit for less extensive breast surgery. Evidence for the association of such survival data with locoregional recurrence rates is largely lacking.MethodsThe Swedish Multicentre Cohort Study prospectively included clinically node‐negative patients with breast cancer who had planned sentinel node biopsy between 2000 and 2004. Axillary lymph node dissection was undertaken only in patients with sentinel node metastases. For the present investigation, adjusted survival analyses were used to compare patients who underwent BCS and postoperative radiotherapy with those who received mastectomy without radiotherapy.ResultsOf 3518 patients in the Swedish Multicentre Cohort Study, 2767 were included in the present analysis; 2338 had BCS with postoperative radiotherapy and 429 had mastectomy without radiotherapy. Median follow‐up was 156 months. BCS followed by whole‐breast irradiation was superior to mastectomy without irradiation in terms of both overall survival (79·5 versus 64·3 per cent respectively at 13 years; P < 0·001) and breast cancer‐specific survival (90·5 versus 84·0 per cent at 13 years; P < 0·001). The local recurrence rate did not differ between the two groups. The axillary recurrence‐free survival rate at 13 years was significantly lower after mastectomy without irradiation (98·3 versus 96·2 per cent; P < 0·001).ConclusionThe present data support the superiority of BCS with postoperative radiotherapy over mastectomy without radiotherapy. The axillary recurrence rate differed significantly, and could be one contributing factor in a complex explanatory model.

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Early-Stage Young Breast Cancer Patients: Impact of Local Treatment on Survival

Abstract: In this large population-based cohort of early-stage young breast cancer patients, 10-year OS was not impaired after BCT compared with mastectomy. Patients with 1 to 3 positive lymph nodes had better prognosis after BCT than after mastectomy.

Cited by 52 publications

References 32 publications

Impact of age, intrinsic subtype and local treatment on long-term local-regional recurrence and breast cancer mortality among low-risk breast cancer patients

Impact of age, intrinsic subtype and local treatment on long-term local-regional recurrence and breast cancer mortality among low-risk breast cancer patients

Clinical and Histopathologic Characteristics of Breast Cancer Cases Aged 35 Years and Younger

Breast-conserving surgery followed by whole-breast irradiation offers survival benefits over mastectomy without irradiation

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