Early Stage Impacts of Adenoidectomy With/Without Tonsillectomy on Immune Functions of Children Aged Less Than Three Years

Yan, Yuyan; Song, Yanjie; Liu, Yingying; Su, Jinzhu; Li, Cui; Wang, Juan; Geng, Jiangqiao; Liu, Xiaofeng; Shi, Yanan; Quan, Songxia; Zuo, Lujie

doi:10.1089/ped.2018.0964

Cited by 6 publications

(4 citation statements)

References 22 publications

(27 reference statements)

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“…Whenever left untreated, AH may prompt obstructive sleep apnea (snuffling, uneasiness, mouth breathing), ear issues, pulmonary hypertension, craniofacial peculiarities and inability to thrive. 2 However, diagnosis can be thought provoking in a patient with AH symptoms. There are list of recommendations for the diagnosis of AH but recent studies suggested that X-rays soft tissue neck lateral view and nasal endoscopy either rigid or flexible are the gold standard investigations for AH diagnosis.…”

Section: Introductionmentioning

confidence: 99%

Clinical outcome of Montelukast Sodium in Children with Adenoid Hypertrophy

et al. 2021

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Background & Objectives: Generally, the blockage of upper respiratory tract in children is seen with the hypertrophy of adenoids and tonsils. Normally for patients with adenoid hypertrophy (AH), Adenoidectomy with or without Tonsillectomy is carried out, however it has its own complications like haemorrhage and recurrence of adenoid tissue. Consequently, therapeutic approach has increased extraordinary consideration rather than surgical procedure. The inflammatory process proposed for AH has prompted the utilization of anti-inflammatory drugs to treat this issue. The objective of this study was to assess the impacts of Montelukast sodium in children with enlarged adenoids. Methods: A randomized controlled trail was performed from April 2018 to March 2019 in the Otorhinolaryngology clinic of Dr. Akbar Niazi Teaching Hospital, Islamabad. In this randomized, placebo treatment-controlled trial, 60 children aged 4-12 years meeting inclusion criteria were isolated into two groups. The study group was treated with Montelukast sodium 5mg consistently for three months while the control group got placebo treatment for a similar timeframe. A questionnaire was filled by parents/ guardians of every child before and after the intervention to evaluate the severity of sleep discomfort, snoring and mouth breathing. Results: Following 3 months of treatment, significant reduction in size of the adenoids was seen in 76% of study group compared with just 3% of control group getting placebo treatment. Conclusion: Montelukast sodium seems to be effective in the reduction of the size of adenoids and improvement in clinical manifestations. It can be viewed as a viable option in contrast to surgical treatment in children with hypertrophy of adenoids. doi: https://doi.org/10.12669/pjms.37.2.2670 How to cite this:Naqi SA, Ashfaq AH, Umar MA, Karmani JK, Arshad N. Clinical outcome of Montelukast Sodium in Children with Adenoid Hypertrophy. Pak J Med Sci. 2021;37(2):---------. doi: https://doi.org/10.12669/pjms.37.2.2670 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Section: Introductionmentioning

confidence: 99%

Clinical outcome of Montelukast Sodium in Children with Adenoid Hypertrophy

et al. 2021

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“…Surgical treatment, particularly adenoidectomy, is recommended for children with snoring. By removing the hypertrophic adenoids, adenoidectomy alleviates nasal congestion and Trop J Pharm Res, February 2024; 23 (2): 364 hypoventilation that occur during sleep at night [4][5][6]. Nasal endoscopic adenoidectomy has become the preferred treatment method for snoring in children due to advancements in nasal endoscope technology.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of propofol and remifentanil combination for controlled hypotension during anesthesia in pediatric nasal endoscopic surgery

Li,

Ye,

Wang

2024

Trop. J. Pharm Res

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Purpose: To investigate the safety and efficacy of propofol in combination with remifentanil for controlled hypotension during pediatric nasal endoscopic surgery. Methods: The study involved 30 patients who underwent controlled hypotension measures with remifentanil during the operation (study group), and 30 patients who did not receive controlled hypotension measures (control group). Various parameters including vital signs, operation time, intraoperative bleeding, surgical field quality, anesthesia quality, postoperative recovery time, adverse reaction rate, pain scores, and serum C-reactive protein levels were compared between the two groups. Results: The results revealed a significant decrease in mean arterial pressure and heart rate in the study group during the operation compared to control group. Moreover, study group exhibited improved operation time, reduced intraoperative bleeding, and better surgical field quality compared to control group. Pain scores and serum C-reactive protein levels were also lower in the study group. However, there were no significant differences in recovery time, anesthesia quality, postoperative adverse reaction rate, or cognitive function between the two groups. Conclusion: Propofol in combination with remifentanil for controlled hypotension is a safe and effective anesthesia approach for pediatric nasal endoscopic surgery. Future studies will require larger sample size from different study centers to improve the robustness of the findings of this study.

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“…Adenoid is little in size at earliest stages yet increments in initial four years of life because of the improvement of immunity. Whenever left untreated, Adenoid Hypertrophy may prompt obstructive sleep apnea (snuffling, rest uneasiness, mouth breathing), ear issues, pulmonary hypertension, craniofacial peculiarities and inability to thrive [2]. In any case, the conclusion can be provocative in patients with manifestations of AH.…”

Section: Introductionmentioning

confidence: 99%

Clinical Outcomes of Montelukast Sodium in Children with Adenoid Hypertrophy

Kumar¹

2020

BJSTR

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Background: Generally the blockage of upper respiratory tract in children is seen with the hypertrophy of adenoids and tonsils. Normally for patients with adenoid hypertrophy (AH), Adenoidectomy with or without Tonsillectomy is carried out, however it has its own genuine complications like haemorrhage and recurrence of adenoid tissue. Consequently, therapeutic treatment has increased extraordinary consideration rather than surgical procedure. The inflammatory process proposed for AH has prompted the utilization of anti-inflammatory drugs to treat this issue. The purpose of this study is to assess the impacts of Montelukast sodium in children with enlarged adenoids. Materials and Methods:In this randomized, placebo treatment controlled trial, 60 children aged 4-12 years meeting inclusion criteria were isolated into two groups. The study group was treated with Montelukast sodium 5mg consistently for 3 months while the control group got placebo treatment for a similar timeframe. A questionnaire was filled by parents/ guardians of every child before and after the intervention to evaluate the severity of sleep discomfort, snoring and mouth breathing, Results: Following 3 months of treatment, significant reduction in size of the adenoids was seen in 76% of study group compared with just 3% of control group getting placebo treatment. Conclusion:Montelukast sodium is seen to be effective in the reduction of the size of adenoids and improvement in clinical manifestations and can be viewed as a viable option in contrast to surgical treatment in children with hypertrophy of adenoids.

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Early Stage Impacts of Adenoidectomy With/Without Tonsillectomy on Immune Functions of Children Aged Less Than Three Years

Cited by 6 publications

References 22 publications

Clinical outcome of Montelukast Sodium in Children with Adenoid Hypertrophy

Clinical outcome of Montelukast Sodium in Children with Adenoid Hypertrophy

Evaluation of propofol and remifentanil combination for controlled hypotension during anesthesia in pediatric nasal endoscopic surgery

Clinical Outcomes of Montelukast Sodium in Children with Adenoid Hypertrophy

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