Early-stage alcohol-induced cardiomyopathy: not so much dilatation and dysfunction

Carrillo-Bailen, Magdalena; ElMahraoui, Kaltoum; Urbano-Moral, José Ángel

doi:10.1093/ehjcr/ytad137

Cited by 1 publication

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“…11 However, this approach may overlook the earlier stages of alcohol-induced liver and cardiac injury, such as fibrosis and morphofunctional changes, which are crucial to understanding the full spectrum of alcohol's burden on liver and cardiovascular health. 40,41 Fourth, the definition of young adult largely varies; we used the cut of 15-49 years old since the closest range of young adults that GBD offers is this age, and we acknowledge that this could include some population of middle-aged adults.…”

Section: Discussionmentioning

confidence: 99%

Socio‐economic association of alcohol use disorder and cardiovascular and alcohol‐associated liver disease from 2010 to 2019

Danpanichkul,

Chen,

Chaiyakunapruk

et al. 2024

Aliment Pharmacol Ther

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SummaryBackgrounds and AimsAlcohol use leads to disabilities and deaths worldwide. It not only harms the liver but also causes alcohol use disorder (AUD) and heart disease. Additionally, alcohol consumption contributes to health disparities among different socio‐economic groups.MethodsWe estimated global and regional trends in the burden of AUD, liver disease, and cardiovascular disease from alcohol using the methodology of the Global Burden of Disease study.ResultsIn 2019, the highest disability‐adjusted life years rate per 100,000 population was due to AUD (207.31 [95% Uncertainty interval (UI) 163.71–261.66]), followed by alcohol‐associated liver disease (ALD) (133.31 [95% UI 112.68–156.17]). The prevalence rate decreased for AUD (APC [annual percentage change] −0.38%) and alcohol‐induced cardiomyopathy (APC −1.85%) but increased for ALD (APC 0.44%) and liver cancer (APC 0.53%). Although the mortality rate for liver cancer from alcohol increased (APC 0.30%), mortality rates from other diseases decreased. Between 2010 and 2019, the burden of alcohol‐associated complications increased in countries with low and low‐middle sociodemographic index (SDI), contributing more significantly to the global burden.ConclusionThe global burden of AUD, liver, and cardiovascular disease has been high and increasing over the past decade, particularly for liver complications. Lower SDI countries are contributing more to this global burden. There is a pressing need for effective strategies to address this escalating burden.

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Section: Discussionmentioning

confidence: 99%