Early squamous cell carcinoma of the lung: CT and pathologic correlation.

Saida, Yuuto; Kujiraoka, Yuka; Akaogi, Eiichi; Ogata, Tamae; Kurosaki, Yoshihisa; Itai, Yuji

doi:10.1148/radiology.201.1.8816521

Cited by 16 publications

(8 citation statements)

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“…1 Overall, squamous cell lung cancer represents approximately 25% of lung cancer and it is believed that reversible pre-invasive epithelial proliferation and squamous cell carcinoma-in-situ precedes its arrival. 2 While retrospective attempts at CT-based imaging of early central airway cancers have been reported, 3 the detection of early squamous cell carcinoma has not been a common feature of CT-based screening trials, 4 5 even when these trials are complemented by sputum cytology. In addition, the identification of frank carcinoma in sputum for the purpose of diagnosis has failed to reduce lung cancer mortality in randomised controlled trials.…”

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confidence: 99%

Autofluorescence bronchoscopy for lung cancer surveillance based on risk assessment

Loewen

Natarajan

Tan

et al. 2007

Thorax

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Background: This is a preliminary report of an ongoing prospective bimodality lung cancer surveillance trial for high-risk patients. Bimodality surveillance incorporates autofluorescence bronchoscopy (AFB) and spiral CT (SCT) scanning in high-risk patients as a primary lung cancer surveillance strategy, based entirely on risk factors. AFB was used for surveillance and findings were compared with conventional sputum cytology for the detection of malignancy and pre-malignant central airway lesions. Methods: 402 patients registering at Roswell Park Cancer Institute were evaluated with spirometric testing, chest radiography, history and physical examination, of which 207 were deemed eligible for the study. For eligibility, patients were required to have at least two of the following risk factors: (1) >20 pack year history of tobacco use, (2) asbestos-related lung disease on the chest radiograph, (3) chronic obstructive pulmonary disease with a forced expiratory volume in 1 s (FEV 1 ) ,70% of predicted, and (4) prior aerodigestive cancer treated with curative intent, with no evidence of disease for .2 years. All eligible patients underwent AFB, a low-dose SCT scan of the chest without contrast, and a sputum sample was collected for cytological examination. Bronchoscopic biopsy findings were correlated with sputum cytology results, SCT-detected pulmonary nodules and surveillance-detected cancers. To date, 186 have been enrolled with 169 completing the surveillance procedures. Results: Thirteen lung cancers (7%) were detected in the 169 subjects who have completed all three surveillance studies to date. Pre-malignant changes were common and 66% of patients had squamous metaplasia or worse. Conventional sputum cytology missed 100% of the dysplasias and 68% of the metaplasias detected by AFB, and failed to detect any cases of carcinoma or carcinoma-in-situ in this patient cohort. Sputum cytology exhibited 33% sensitivity and 64% specificity for the presence of metaplasia. Seven of 13 lung cancers (58%) were stage Ia or less, including three patients with squamous cell carcinoma. Patients with peripheral pulmonary nodules identified by SCT scanning of the chest were 3.16 times more likely to exhibit pre-malignant changes on AFB (p,0.001). Conclusion: Bimodality surveillance will detect central lung cancer and pre-malignancy in patients with multiple lung cancer risk factors, even when conventional sputum cytology is negative. AFB should be considered in high-risk patients, regardless of sputum cytology findings.

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confidence: 99%

Autofluorescence bronchoscopy for lung cancer surveillance based on risk assessment

Loewen

Natarajan

Tan

et al. 2007

Thorax

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“…It is generally accepted that the bronchoscopic findings of endobronchial lesions of primary lung carcinoma are difficult to distinguish from those of metastatic lung carcinoma and non-malignant tumors (12,13). Bronchoscopic examinations are used for the diagnosis of endobronchial lesions as the majority of lesions are within the view and range of the bronchoscopic field.…”

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confidence: 99%

Small cell lung cancer with endobronchial growth: A case report

et al. 2013

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The current study presents a rare case of small cell lung cancer (SCLC) with endobronchial growth in a 68-year-old male. Chest CT scans revealed an ill-defined mass in the upper lobe of the right lung, with ipsilateral mediastinial lymph node swelling. An endobronchial polypoid tumor in the right B3 bronchus was located by bronchoscopic examination. The analysis of a biopsy specimen obtained from the tumor resulted in a diagnosis of SCLC. Although extremely rare, this case highlights the importance of considering a diagnosis of SCLC in patients presenting with a pulmonary tumor adjacent to the bronchus, with an endobronchial polypoid lesion.

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“…La tomografía facilita una mejor caracterización del carcinoma escamocelular dado que este tumor puede pasar oculto en las radiografías (9). La particularidad más importante es su localización central por compromiso de los bronquios lobares o segmentarios (figura 2).…”

Section: Tomografía Computarizadaunclassified

“…A diferencia del adenocarcinoma de pulmón, en el carcinoma escamocelular las metástasis tienden a ser una manifestación radiológica tardía (1). La principal vía de diseminación del carcinoma escamocelular de pulmón es la extensión local a ganglios linfáticos hiliares o mediastinales (9). La diseminación linfangítica con engrosamiento liso o nodular de los septos interlobulillares, subpleurales y peribroncovasculares no es una característica frecuente en el carcinoma escamocelular, y su presencia debe hacer sospechar un adenocarcinoma.…”

Section: Tomografía Computarizadaunclassified

Carcinoma escamocelular de pulmón

García

Rodríguez-Takeuchi

Escobar

2016

rev. colomb. neumol.

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El carcinoma escamocelular representa el 30% de los tumores pulmonares (1). En el 2015 la Organización Mundial de la Salud (OMS) publicó una actualización de la clasificación de este tumor incluyendo cuatro subtipos histológicos: queratinizante, no-queratinizante, basaloide e in situ (2). Radiografía de tórax La mayoría de veces estos tumores se localizan en forma central en el pulmón dentro de los bronquios

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Early squamous cell carcinoma of the lung: CT and pathologic correlation.

Abstract: CT is a valuable tool for diagnosis of early squamous cell carcinomas, particularly when lesions show polypoid growth and/or invade the cartilaginous layer.

Cited by 16 publications

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Autofluorescence bronchoscopy for lung cancer surveillance based on risk assessment

Autofluorescence bronchoscopy for lung cancer surveillance based on risk assessment

Small cell lung cancer with endobronchial growth: A case report

Carcinoma escamocelular de pulmón

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