Early specification of intestinal epithelium in the chicken embryo: A study on the localization and regulation of <i>CdxA</i> expression

Ishíi, Yasuo; Fukuda, Kiyoshige; Saiga, Hidetoshi; Matsushita, Susumu; Yasugi, Sadao

doi:10.1046/j.1440-169x.1997.t01-4-00012.x

Cited by 96 publications

(70 citation statements)

References 30 publications

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“…These plasmids were used to prepare digoxygenin-labeled antisense RNA probes. In situ hybridization of frozen tissue sections were performed as described by Ishii et al (13).…”

Section: Methodsmentioning

confidence: 99%

Identification of a photoreceptor cell-specific nuclear receptor

Kobayashi

Takezawa

Hara

et al. 1999

Proc. Natl. Acad. Sci. U.S.A.

183

180

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Nuclear receptors comprise a large and expanding family of transcription factors involved in diverse aspects of animal physiology and development, the functions of which can be modulated in a spatial and temporal manner by access to small lipophilic ligands and/or the specificity of their own localized expression. Here we report the identification of a human nuclear receptor that reveals a unique proximal box (CNGCSG) in the DNA-binding domain. The conservation of this feature in its nematode counterpart suggests the requirement for this type of P box in the genetic cascades mediated by nuclear receptors in a wide variety of animal species. The expression of this receptor, PNR (photoreceptor-specific nuclear receptor), appears strongly restricted in the retina, exclusively in photoreceptor cells. In human cell lines, PNR expression was observed in Y79 retinoblastoma along with other photoreceptor marker genes such as CRX. Among vertebrate receptors, PNR shares structural kinship with an orphan receptor TLX, and despite distinct differences in the DNA binding domain, PNR is able to recognize a subset of TLX target sequences in vitro. Analyses of the human PNR gene revealed its chromosomal position as 15q24, a site that has recently been reported as a susceptible region for retinal degeneration. These data support a role for PNR in the regulation of signalling pathways intrinsic to the photoreceptor cell function.

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“…These plasmids were used to prepare digoxygenin-labeled antisense RNA probes. In situ hybridization of frozen tissue sections were performed as described by Ishii et al (13).…”

Section: Methodsmentioning

confidence: 99%

Identification of a photoreceptor cell-specific nuclear receptor

Kobayashi

Takezawa

Hara

et al. 1999

Proc. Natl. Acad. Sci. U.S.A.

183

180

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“…Ishii and colleagues showed that the stomach epithelium is posteriorized by small intestine epithelium until E4 (equivalent to 11.5 dpc in the mouse) but at E6 (about 12.5dpc) although signals are still produced by the mesenchyme, the endoderm has lost its ability to express the intestinal markers CdxA and sucrase (Ishii et al, 1997, Ishii et al, 1998 (Haffen et al, 1982, Ishizuya-Oka andMizuno, 1984). In agreement, 14.5dpc stomach or lung epithelium do not appear to be influenced by small intestine mesenchyme (Duluc et al, 1994).…”

Section: Lateral Plate Mesoderm Located At Different A-p Positions Sementioning

confidence: 99%

Antero-posterior patterning of the vertebrate digestive tract: 40 years after Nicole Le Douarin's PhD thesis

Grapin-Botton¹

2005

Int. J. Dev. Biol.

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This review is dedicated to the work on chick digestive tract organogenesis that Nicole Le Douarin performed as a PhD student under the direction of Etienne Wolf. I discuss how she laid the grounds for future work by establishing fate maps at somitic stages, by describing morphogenetic movements between germ layers and by pointing to signaling events between endoderm and mesoderm. Her inspiring work was extended by others, in particular at the molecular level, leading to a better understanding of antero-posterior patterning in the digestive tract. Antero-posterior patterning of endoderm is initiated at gastrulation when future anterior and posterior endoderm ingress at different times and accordingly express different genes. Plasticity is however maintained at somite stages and even later, when organ primordia can be delineated. There is a cross-talk between endoderm and mesoderm and the two layers exchange instructive signals that induce specific antero-posterior identities as well as permissive signals required for organogenesis from previously patterned fields. Recent experiments suggest that several signaling molecules involved in neural tube antero-posterior patterning are also instrumental in the digestive tract including retinoic acid and FGF4.

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“…Whole-mount and section in situ hybridization were carried out as previously described (Wilkinson, 1992;Parr et al, 1993;Ishii et al, 1997). We purchased two IM-AGE cDNA clones (Lennnon et al, 1996) from Research Genetics (Huntsville, AL).…”

Section: In Situ Hybridizationmentioning

confidence: 99%

Spatial and temporal expression of folate‐binding protein 1 (Fbp1) is closely associated with anterior neural tube closure in mice

Saitsu

Ishibashi

Nakano

et al. 2002

Developmental Dynamics

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Periconceptional folate supplementation is widely believed to have significant preventive effects on the production of neural tube defects. Folate-binding protein 1 (FBP1) is one of the membrane proteins that mediate cellular uptake of folate. Although recent studies suggest that Fbp1 is essential for neural tube closure, the pattern of Fbp1 expression in embryonic tissues has not been examined in detail. To elucidate how Fbp1 contributes to neural tube closure, we examined the spatial and temporal expression patterns of Fbp1 in the developing neural folds and tube of mouse embryos by in situ hybridization. Fbp1 showed a distinct expression pattern in the neural folds, which preceded initiation of neural tube closure at the cervical region and the prosencephalic/mesencephalic boundary.

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Early specification of intestinal epithelium in the chicken embryo: A study on the localization and regulation of CdxA expression

Cited by 96 publications

References 30 publications

Identification of a photoreceptor cell-specific nuclear receptor

Identification of a photoreceptor cell-specific nuclear receptor

Antero-posterior patterning of the vertebrate digestive tract: 40 years after Nicole Le Douarin's PhD thesis

Spatial and temporal expression of folate‐binding protein 1 (Fbp1) is closely associated with anterior neural tube closure in mice

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