Early Spatial and Temporal Changes in Tumour Perfusion after Administration of Flavone Acetic Acid

Peters, Carrie E.; Trotter, M.J.; Chaplin, David J.

doi:10.1080/09553009114552111

Cited by 7 publications

(4 citation statements)

References 17 publications

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“…The results could be related to the known effects of the therapeutic drug FAA (27). Vascular permeability might increase due to initial drug intervention; later the vessels collapsed and resulted in a decreased vascular volume.…”

Section: K 2 In Controls and Respondersmentioning

confidence: 88%

Investigation of longitudinal vascular changes in control and chemotherapy-treated tumors to serve as therapeutic efficacy predictors

Su¹,

Wang²,

Nalcioğlu³

1999

J. Magn. Reson. Imaging

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Section: K 2 In Controls and Respondersmentioning

confidence: 88%

Investigation of longitudinal vascular changes in control and chemotherapy-treated tumors to serve as therapeutic efficacy predictors

Su¹,

Wang²,

Nalcioğlu³

1999

J. Magn. Reson. Imaging

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“…In a similar way, the vaso-active drug hydralazine is thought to enhance the cytotoxic effect of melphalan by reducing the rate of tumour clearance (Stratford et a/., 1988). With the majority of the tumour already necrotic through the action of FAA, the trapped radioantibody may then exert its effect by irradiating any pockets of remaining cells within the tumour and also the viable cells at the rim, aided by circulating activity at the periphery where the vessels are less affected by the drug (Peters et al, 1991). Tumour autoradiographs from mice given a biodistribution dose of lz5I-A5B7 alone showed viable tumour with the majority of antibody localization around blood vessels.…”

Section: Efect Of F a A On Biodistrib~ition Of Radioantibodymentioning

confidence: 99%

“…It reduces blood flow and induces coagulopathy and haemorrhagic necrosis in the tumour as early as 4 hr after administration in mice, with larger tumours experiencing more vascular dysfunction than small ones. Within 24 hr up to 95% of the tumour may become necrotic, and no tumour regrowth will occur from this region, suggesting that cessation of blood flow following FAA is irrcversible (Peters et a/., 1991). The mechanism of action is not only direct cytotoxicity.…”

mentioning

confidence: 99%

Enhancement of radioimmunotherapy by drugs modifying tumour blood flow in a colonic xenograft model

Pedley

Begent

Boden

et al. 1994

Intl Journal of Cancer

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Radioimmunotherapy (RIT) is hampered clinically by poor tumour localization of antibody. In order to enhance localization we have investigated the concomitant use of RIT with 2 drugs, flavone-8-acetic acid (FAA) and its analogue 5,6-dimethylxanthenone-4-acetic acid (XAA), which both reduce tumour blood flow and induce immunomodulation. A single i.v. dose of 0.5 mCi (18.5 MBq) intact 131I anti-CEA antibody significantly delayed growth and prolonged survival over that of untreated controls, in an established LS174T colon xenograft model in nude mice. The adjuvant use of a single i.p. dose of either FAA or XAA, given 24 or 48 hr after 131I-A5B7 to allow maximum tumour levels of antibody to be attained before drug-induced blood-flow inhibition, significantly enhanced the RIT. FAA caused entrapment of antibody within the tumour in relation to the time allowed for localization before drug administration. Repeated doses of FAA prolonged tumour growth inhibition but did not enhance the therapy achieved after a single dose. Although both drugs alone induced massive tumour necrosis of all but a thin peripheral rim of viable cells, tumour regrowth was inhibited for a few days only, with no effect on survival. Drug-induced tumour necrosis, immunomodulation and retention of higher doses of 131I-A5B7 within the tumour may contribute to the enhanced RIT produced by this combined therapy.

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“…A number of di erent drugs have been reported to decrease tumour blood¯ow (Vaupel et al 1989, Lin and Song 1990, Hasegawa and Song 1991, Hirst et al 1991, Honess and Bleehen 1991, Peters et al 1991. Unfortunately, these drugs were found to signi® cantly a ect not only the tumour blood¯ow but also the normal tissue blood¯ow.…”

Section: Discussionmentioning

confidence: 96%

Reduction of tumour blood flow with KB-R8498 potentiates the response of tumours to hyperthermia

Shakil

Ogawa²,

Griffin³

et al. 1999

International Journal of Hyperthermia

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The anti-tumour activity and the effect on tumour and normal tissue perfusion of a newly discovered anticancer agent, KB-R8498 (Kanebo Ltd., Osaka, Japan), were investigated in FSa II tumours of C3H mice. The tumour perfusion, as measured by the 86Rb-uptake method, markedly decreased with relatively little change in the normal tissue perfusion after an i.v. injection of KB-R8498. Furthermore, the drug potentiated the effect of hyperthermia at 42.5 degrees C for 60 min to suppress the tumour growth. The results suggest that the preferential reduction in tumour blood flow relative to normal tissue blood flow by KB-R8498 may be exploited to enhance the anti-tumour effect of hyperthermia.

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Early Spatial and Temporal Changes in Tumour Perfusion after Administration of Flavone Acetic Acid

Cited by 7 publications

References 17 publications

Investigation of longitudinal vascular changes in control and chemotherapy-treated tumors to serve as therapeutic efficacy predictors

Investigation of longitudinal vascular changes in control and chemotherapy-treated tumors to serve as therapeutic efficacy predictors

Enhancement of radioimmunotherapy by drugs modifying tumour blood flow in a colonic xenograft model

Reduction of tumour blood flow with KB-R8498 potentiates the response of tumours to hyperthermia

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