Early small bowel perforation and cochleovestibular impairment as rare complications of typhoid fever

Wolfswinkel, Marlies E van; Lahri, Hakima; Wismans, Pieter J.; Petit, P. L. C.; Genderen, Perry J.J. van

doi:10.1016/j.tmaid.2009.06.003

Cited by 4 publications

(1 citation statement)

References 13 publications

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“…2 A few cases of typhoid fever manifesting as sensorineural hearing loss have been reported. [3][4][5] The exact mechanism remains unclear, but factors such as host susceptibility, endotoxins, arteritis, and ischaemia may contribute. 6 The primary treatment for sensorineural hearing loss in typhoid is antibiotics; studies on the use of steroids as an adjunctive therapy are limited.…”

Section: Discussionmentioning

confidence: 99%

Sensorineural hearing loss as an atypical presentation of typhoid fever: A case report

Javad KV,

Saif,

Kalathil

et al. 2024

Trop Doct

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Typhoid fever, also known as enteric fever, is a multisystemic infection primarily caused by Salmonella enterica serotype Typhi, and less commonly by Salmonella enterica serotypes Paratyphi A, B, and C. The classic presentation includes fever, malaise, diffuse abdominal pain, and constipation. If left untreated, typhoid fever can progress to delirium, obtundation, intestinal haemorrhage, bowel perforation, and death within a month of onset. However, the clinical course can deviate from the classic stepladder fever pattern, which now occurs in as few as 12% of cases. 1 In this report, we describe an atypical presentation as sensorineural hearing loss in an otherwise healthy young male.

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Section: Discussionmentioning

confidence: 99%

Sensorineural hearing loss as an atypical presentation of typhoid fever: A case report

Javad KV,

Saif,

Kalathil

et al. 2024

Trop Doct

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Acute Gastritis and Enteritis

Régent

Croisé-Laurent

Mathias

et al. 2010

CT of the Acute Abdomen

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Decreased ciprofloxacin susceptibility in Salmonella Typhi and Paratyphi infections in ill-returned travellers: the impact on clinical outcome and future treatment options

Hassing

Goessens

Mevius

et al. 2013

Eur J Clin Microbiol Infect Dis

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The emergence of decreased ciprofloxacin susceptibility (DCS) in Salmonella enterica serovar Typhi and serovar Paratyphi A, B or C limits treatment options. We studied the impact of DCS isolates on the fate of travellers returning with enteric fever and possible alternative treatment options. We evaluated the clinical features, susceptibility data and efficacy of empirical treatment in patients with positive blood cultures of a DCS isolate compared to patients infected with a ciprofloxacin-susceptible (CS) isolate in the period from January 2002 to August 2008. In addition, the pharmacokinetic and pharmacodynamic parameters of ciprofloxacin, levofloxacin and gatifloxacin were determined to assess if increasing the dose would result in adequate unbound fraction of the drug 24-h area under the concentration-time curve/minimum inhibitory concentration (ƒAUC(0-24)/MIC) ratio. Patients with DCS more often returned from the Indian subcontinent and had a longer fever clearance time and length of hospital stay compared to patients in whom the initial empirical therapy was adequate. The mean ƒAUC(0-24)/MIC was 41.3 ± 18.8 in the patients with DCS and 585.4 ± 219 in patients with a CS isolate. For DCS isolates, the mean ƒAUC0-24/MIC for levofloxacin was 60.5 ± 28.7 and for gatifloxacin, it was 97.9 ± 28.0. Increasing the dose to an adequate ƒAUC(0-24)/MIC ratio will lead to conceivably toxic drug levels in 50% of the patients treated with ciprofloxacin. Emerging DCS isolates has led to the failure of empirical treatment in ill-returned travellers. We demonstrated that, in some cases, an adequate ƒAUC(0-24)/MIC ratio could be achieved by increasing the dose of ciprofloxacin or by the use of alternative fluoroquinolones.

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Early small bowel perforation and cochleovestibular impairment as rare complications of typhoid fever

Cited by 4 publications

References 13 publications

Sensorineural hearing loss as an atypical presentation of typhoid fever: A case report

Sensorineural hearing loss as an atypical presentation of typhoid fever: A case report

Acute Gastritis and Enteritis

Decreased ciprofloxacin susceptibility in Salmonella Typhi and Paratyphi infections in ill-returned travellers: the impact on clinical outcome and future treatment options

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