Early Sirolimus Therapy in Renal Transplant Recipients at High Risk: Is It Justified?

Halim, Medhat A; Al-Otaibi, Torki; Johny, K.V.; Hamid, M.H; Al‐Waheeb, Salah; Hasaneen, H.; Awadain, Waleed; Nawas, K.M.; El-Sayed, A; Said, Tarek; Nair, Muraleedharan G.; Nampoory, M.R.N.

doi:10.1016/j.transproceed.2009.07.015

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2011

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“…As patients under immunosuppressive therapy with tacrolimus and/or rapamycin are at a higher risk of C. d. infection (5, 19), and also because of the variable entity of symptoms, it may be appropriate to associate anti‐C. d. prophylaxis at every reintroduction of the immunosuppressive therapy.…”

Section: Resultsmentioning

confidence: 99%

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Clostridium difficile-related pancolitis in lung-transplanted patients with cystic fibrosis

Patriarchi

Rolla

Maccioni³

et al. 2011

Clinical Transplantation

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C. difficile (C. d.) is the main cause of antibiotic-associated diarrhea and colitis. It is shown in literature a high asymptomatic carriage rate of C. d. in patients with cystic fibrosis (CF), though C. d.-related colitis is an uncommon complication in these patients, despite the use of multiple high-dose antibiotic regimes and the frequency of hospital admissions. Lung transplantation with the associated immunosuppression and aggressive antibiotic therapy may increase the risk of the clinical manifestation of C. d. In this paper, we describe three cases of severe C. d. colitis in patients with CF following lung transplantation and illustrate our experience in the diagnosis and management of these patients.

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Section: Resultsmentioning

confidence: 99%

“…Rapamycin is an immunosuppressive drug structurally similar to tacrolimus. It is used as the main immunosuppressor in patients with renal failure, because of its lower renal toxicity (4), though it shows increased risk of infections as one of its main side effects (5).…”

Section: Case Report Nomentioning

confidence: 99%