Early Signs of Emotional Recognition Deficits in Adolescent High-Binge Drinkers

Leganes-Fonteneau, Mateo; Pi-Ruano, Marina; Gimeno, Pilar Tejero

doi:10.1080/10826084.2019.1662810

Cited by 10 publications

(5 citation statements)

References 82 publications

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“…Studies in humans and animal models suggest that a history of alcohol consumption reduces social behaviors and increases anxiety-like behaviors, which may involve alcohol-induced adaptations in LHb and/or BNST 5HT2c receptor expression and signaling (Campbell et al, 2021;Fu et al, 2020;Marcinkiewcz et al, 2015;Umhau et al, 2011).To investigate this possibility, we subjected mice to three weeks of DiD, and then after one week of abstinence assessed their behavior in the 3-chamber sociability task , the open field test, and the acoustic startle test (Figure 4A). Notably, this behavioral battery was designed in consideration of robust binge drinking-induced dysregulation of facial emotion recognition and acoustic startle responses reported in humans (Hone et al, 2020;Lannoy et al, 2019;Lannoy et al, 2018;Leganes-Fonteneau et al, 2020;Tolomeo et al, 2021). Consistent with previous reports, both sexes reached significant levels of intoxication as determined by their BACs at 4h (Figure 4B-E).…”

Section: Binge Alcohol Consumption Produces Sex-specific Affective Di...supporting

confidence: 57%

“…To investigate this possibility, we subjected mice to three weeks of DiD, and then after one week of abstinence assessed their behavior in the 3-chamber sociability task, the open field test, and the acoustic startle test (Figure 4A). Notably, this behavioral battery was designed in consideration of robust binge drinking-induced dysregulation of facial emotion recognition and acoustic startle responses reported in humans (Hone et al, 2020; Lannoy et al, 2019; Lannoy et al, 2018; Leganes-Fonteneau et al, 2020; Tolomeo et al, 2021). Consistent with previous reports, both sexes reached significant levels of intoxication as determined by their BACs at 4h (Figure 4B-E).…”

Section: Resultsmentioning

confidence: 99%

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Sex-specific regulation of binge drinking, social, and arousal behaviors by subcortical serotonin 5HT_2creceptor-containing neurons

Flanigan

Hon

D’Ambrosio

et al. 2022

Preprint

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Serotonin 5HT2c receptors have been implicated in the pathophysiology of both mood disorders and substance use disorders, but the precise cells and circuits mediating the effects on behavior have yet to be identified. In this study, we employed anatomical tracing, in-vivo fiber photometry with both calcium and serotonin sensors, electrophysiology, chemogenetics, and genetic manipulations of the 5HT2c receptor to identify two populations of neurons expressing serotonin 5HT2c receptors, one in the lateral habenula and one in the bed nucleus of the stria terminalis, that sex-specifically co-regulate affective behaviors and are modulated by binge alcohol consumption. These findings may have implications for the development of sex-specific treatments for mood disorders and substance use disorders targeting the brain serotonin systems.

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Section: Binge Alcohol Consumption Produces Sex-specific Affective Di...supporting

confidence: 57%

Section: Resultsmentioning

confidence: 99%

Sex-specific regulation of binge drinking, social, and arousal behaviors by subcortical serotonin 5HT_2creceptor-containing neurons

Flanigan

Hon

D’Ambrosio

et al. 2022

Preprint

View full text Add to dashboard Cite

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“…The recognition of facial emotion has also been evaluated in adolescents, where initiation of substance use was associated with enhanced recognition of angry emotions [ 133 ]. Altered emotional processing has also been documented in adolescent binge drinkers [ 134 , 135 , 136 ]. Our findings support previous investigations demonstrating recognition deficits in at-risk adolescents.…”

Section: Discussionmentioning

confidence: 99%

Delta Event-Related Oscillations Are Related to a History of Extreme Binge Drinking in Adolescence and Lifetime Suicide Risk

Ehlers

Wills

Karriker‐Jaffe

et al. 2020

Behavioral Sciences

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Alcohol exposure typically begins in adolescence, and heavy binge drinking is associated with health risk behaviors. Event-related oscillations (EROs) may represent sensitive biomarkers or endophenotypes for early alcohol exposure as well as other risk behaviors such as suicidal thoughts and actions. In this study, young adults (age 18–30 years) of American Indian (AI) (n = 479) and Mexican American (MA) (n = 705) ancestry were clinically assessed, and EROs were generated to happy, sad and neutral faces. Extreme adolescent binge drinking (10+ drinks) was common (20%) in this population of AI/MA and associated with a significantly increased risk of a lifetime history of suicidal acts (SA, suicide attempts, deaths) but not suicidal thoughts (ST, ideation, plans). ST were reported among MA participants, whereas SA were more common among AI young adults. Extreme adolescent binge drinking was also associated with errors in detection of sad and neutral faces, increases in delta ERO energy, and decreases in phase locking (PL), particularly in parietal areas. A lifetime history of ST was associated with increases in delta ERO energy and PL, whereas SA were associated with decreases in both. These studies suggest that ERO measures may represent important potential biomarkers of adolescent extreme binge drinking and risk for suicidal behaviors.

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“…Adolescents who transitioned to extreme binge drinking over 6 years had impaired verbal learning memory, indexed by fewer words recalled than controls, moderate drinkers, and binge drinkers (Nguyen-Louie et al, 2016). The few social cognition studies conducted in young drinkers indicate their difficulties in recognizing emotional expressions of others (Lannoy, Benzerouk, et al, 2019;Leganes-Fonteneau et al, 2020) and suggest that empathy and theory of mind difficulties may be predictive of future binge drinking (Laghi et al, 2019a(Laghi et al, , 2019bLannoy et al, 2020).…”

Section: Brain Structural and Functional Declines Related To Hazardou...mentioning

confidence: 99%

Alcohol drinking and alcohol use disorder across the ages: Dynamic effects on the brain and function.

Sullivan¹,

Lannoy²,

Berre³

et al. 2023

APA Handbook of Neuropsychology, Volume 1: Neurobehavioral Disorders and Conditions: Accepted Science and Open Questions (Vol.

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This chapter focuses on (a) the epidemiology and diagnosis of alcohol use disorder (AUD); (b) neuroradiological signatures of syndromes of AUD and concomitant signs and symptoms; (c) the dynamic course of component neuropsychological processes in drinking and sobriety; and (d) the effects of adolescent drinking on cognitive, motor, and brain function. The conclusion provides a summary of accepted facts about AUD and identifies salient questions about AUD remaining to be answered. WHAT THE FIELD KNOWS Epidemiology and Definition of Excessive Drinking and Alcohol Use DisorderEpidemiology. The World Health Organization (WHO; 2018) Global Status Report on Alcohol and Health 2018 estimated rates of AUD in the United States at 3% to 6% of the population, with a nearly 30% lifetime AUD prevalence. Despite its high prevalence, fewer than 10% of individuals with AUD receive treatment. Determination of drinking patterns considers consumption amount and frequency in the context of National Institute on Alcohol Abuse and Alcoholism (NIAAA) guidelines, which recommend no more than one drink per day (maximum seven drinks per week) for women, no more than two drinks on any one day (maximum 14 drinks per week) for men, and never to drink while pregnant or when planning a pregnancy. Alcohol consumption is increasing among people approaching retirement age, with women exceeding the trajectory increase of men both in regular to heavy drinking and binge drinking (Breslow et al., 2017), although an increase in frequent heavy drinking has also been documented in older men (Han et al., 2019). Binge drinking is defined as consuming more than four (for women) or five (for men) alcohol drinks in 2 hours (NIAAA, 2020).An AUD diagnosis is made based on the criteria listed in the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5; American Psychiatric Association, 2013) or the International Statistical Classification of Disease and Related Health Problems, 10th revision (ICD-10; WHO, 2016). These diagnostic codes depict AUD on a severity spectrum from mild to severe. "Alcohol abuse and alcohol dependence" as a diagnosis is no longer in the nosology. The DSM-5 diagnosis has 11 criteria; the presence of two or more within a 12-month span qualifies as an AUD. Especially relevant to recognizing how AUD contributes to cognitive compromise of frontally based functions involving social cognition and perseveration are two criteria:

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Early Signs of Emotional Recognition Deficits in Adolescent High-Binge Drinkers

Cited by 10 publications

References 82 publications

Sex-specific regulation of binge drinking, social, and arousal behaviors by subcortical serotonin 5HT_2creceptor-containing neurons

Sex-specific regulation of binge drinking, social, and arousal behaviors by subcortical serotonin 5HT_2creceptor-containing neurons

Delta Event-Related Oscillations Are Related to a History of Extreme Binge Drinking in Adolescence and Lifetime Suicide Risk

Alcohol drinking and alcohol use disorder across the ages: Dynamic effects on the brain and function.

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Early Signs of Emotional Recognition Deficits in Adolescent High-Binge Drinkers

Cited by 10 publications

References 82 publications

Sex-specific regulation of binge drinking, social, and arousal behaviors by subcortical serotonin 5HT2creceptor-containing neurons

Sex-specific regulation of binge drinking, social, and arousal behaviors by subcortical serotonin 5HT2creceptor-containing neurons

Delta Event-Related Oscillations Are Related to a History of Extreme Binge Drinking in Adolescence and Lifetime Suicide Risk

Alcohol drinking and alcohol use disorder across the ages: Dynamic effects on the brain and function.

Contact Info

Product

Resources

About

Sex-specific regulation of binge drinking, social, and arousal behaviors by subcortical serotonin 5HT_2creceptor-containing neurons

Sex-specific regulation of binge drinking, social, and arousal behaviors by subcortical serotonin 5HT_2creceptor-containing neurons