Early Secondary Alveoloplasty in Cleft Lip and Palate

Arangio, Paolo; Marianetti, Tito Matteo; Tedaldi, Massimiliano; Ramieri, Valerio; Cascone, Piero

doi:10.1097/scs.0b013e31818434c3

Cited by 17 publications

(17 citation statements)

References 25 publications

(20 reference statements)

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“…42 On the other hand, a late movement might cause less than desired bone formation to maintain the height of the repaired alveolar. 43,44 Whether a movement earlier than the 4 weeks (significant b-TCP degradation was noticed) might be more beneficial needs exploration in the future.…”

Section: Discussionmentioning

confidence: 98%

Orthodontic Tooth Movement in Alveolar Cleft Repaired with a Tissue Engineering Bone: An Experimental Study in Dogs

Zhang

Chu

Yang

et al. 2011

Tissue Engineering Part A

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Tissue engineering approaches have been successfully used in repairing bone defects and have become a viable alternative to autologous bone. The aim of the present study was to investigate if a construct of porous beta-tricalcium phosphate (β-TCP) combined with osteogenically induced bone marrow stromal cells (bMSCs) could repair alveolar cleft, and allow for subsequent orthodontic tooth movement in a canine model. Twelve alveolar osteotomy surgeries in six animals were made bilaterally and randomly implanted by (1) tissue-engineered bone complex of bMSCs/β-TCP (group A, n=4), (2) β-TCP alone (group B, n=4), and (3) autologous bone obtained from iliac bone (group C, n=4). Contralateral alveolar defects were created in one animal and left untreated to serve as blank control to observe spontaneous healing of the defects. Sequential fluorescent labeling and radiographic observation was used to evaluate new bone formation and mineralization in each defect. Orthodontic tooth movement was initiated 8 weeks after surgical operation for 12 weeks, and then the dogs were sacrificed for histological and histomorphometric analysis. Results indicated that the tissue-engineered complex with bMSCs/β-TCP dramatically promoted new bone formation and mineralization and achieved a favorable height of the repaired alveolar when compared with β-TCP alone, which absorbed severely. The overall effect of the tissue-engineered bone was equivalent to autologous bone; the physiological function of the alveolar bone was restored by allowing the adjacent teeth to move into the newly formed bone in the grafted region. This study demonstrated that the tissue engineering bone from the combination of β-TCP and bMSCs is a feasible clinical approach for patients with alveolar cleft and the subsequent orthodontic tooth movement.

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Section: Discussionmentioning

confidence: 98%

Orthodontic Tooth Movement in Alveolar Cleft Repaired with a Tissue Engineering Bone: An Experimental Study in Dogs

Zhang

Chu

Yang

et al. 2011

Tissue Engineering Part A

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“…12,13 Donor site morbidity has forced many surgeons to search for better and less painful donor sites, namely cranial vault, tibia, rib, mandibular symphysis, and alveolar bone. 7 Some techniques using a trephine or a curette to harvest cancellous iliac bone have been described to avoid some of the inconveniences of crest donor site; incision is limited, but pain with deambulation continues to be a problem. 12 It must be pointed out that despite this description, these techniques have not been widely accepted and, in the growing child with a thin cancellous space, could result in inadvertent peritoneal penetration.…”

Section: Discussionmentioning

confidence: 99%

“…Early and late secondary bone grafts are considered the preferred treatment in the restoration of alveolar bone defects in these patients. 7 Surgical principles include appropriate mucoperiosteal flap design, nasal floor reconstruction, closure of oronasal fistula, packing the bony defect, and adequate coverage of bone graft.…”

Section: Discussionmentioning

confidence: 99%

Secondary Alveolar Bone Grafting

Nadal¹,

Sabás²,

Dogliotti³

et al. 2010

Journal of Craniofacial Surgery

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Management of alveolar cleft has dramatically changed during the last century: secondary alveolar bone grafting is now an integral part of cleft palate and craniofacial center's protocols. The objectives of alveolar repair and bone grafting are as follows: providing a continuous and stable maxillary dental arch, closure of oronasal fistulae, adequate bone for tooth eruption or orthodontic movement, and nasal base support, improving facial aesthetic. Although cancellous iliac bone is the donor site selected more frequently, bone grafts harvested from different sites have been advocated to decrease donor site morbidity.The aim of this study was to propose and evaluate the use of olecranon as a donor site in 24 patients with secondary alveolar cleft. The graft is taken as a single piece to fit the alveolar cleft defect, and it includes periosteum and corticocancellous bone to improve early vascularization and greater volume maintenance.

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“…Alveolar grafting also supports and gives stability to the wing of the nose, improving nasal emission and phonetics by closure of oronasal communication, orthodontic movement, and the insertion of dental implants. Also, better oral hygiene establishment, and limitation of growth disturbances can be achieved [23][24][25] .…”

Section: Discussionmentioning

confidence: 99%

Dental arch expansion after alveolar cleft repair using autogenous bone marrow derived mesenchymal stem cells versus autogenous chin bone graft

Khalifa

Gomaa

2018

Egyptian Dental Journal

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Alveolar cleft repair is well established, with bone grafting in mixed dentition phase. Mesenchymal derived stem cells were applied to different kinds of bone substitute and compared in different animal models..This study aimed to evaluate the bone quality and quantity at the alveolar cleft sites that were repaired with autogenous mesenchymal stem cell and its effect on orthodontic dental arch expansion and compare these results with cases treated with autogenous chin bone graft. Patients and methods:16 patients (14 left and 2 right, 9 males and 7 females)with unilateral alveolar cleft were included in this study. The age range was 7-12 yearswithmean age was 9.5 years. The alveolar cleft was repaired surgically and the patients were divided into 2 groups (8 patients in each one)according to surgical technique of repair. Group I (5 males and 3 females) : surgical repair was done by using autogenous bone marrow derived mesenchymal stem cells. Group II (4 males and 4 females): surgical repair was done by using autogenous chin bone grafting. The patients were undergo to orthodontic dental arch expansion and followed up to 18 months clinically and radiographically to evaluate and compare the effect of grafting types on arch expansion. Results: The results of this study revealed that the patients in group I who treated by stem cell technology have a clinical results superior than the patients in group II who treated with chin bone grafting. Radiographic results revealed that in group I the bone quality and quantity were superior than that in group II. Conclusion: The autogenous bone marrow derived mesenchymal stem cells is a good technique in repair of alveolar cleft as it promote the bone healing capacity with high quantity and quality as well as enhance orthodontic arch expansion.

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Early Secondary Alveoloplasty in Cleft Lip and Palate

Cited by 17 publications

References 25 publications

Orthodontic Tooth Movement in Alveolar Cleft Repaired with a Tissue Engineering Bone: An Experimental Study in Dogs

Orthodontic Tooth Movement in Alveolar Cleft Repaired with a Tissue Engineering Bone: An Experimental Study in Dogs

Secondary Alveolar Bone Grafting

Dental arch expansion after alveolar cleft repair using autogenous bone marrow derived mesenchymal stem cells versus autogenous chin bone graft

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