Early Sea Urchin Embryo as a Model for the Study of Pre-Nervous Functions of Neurotransmitters: New Data

Buznikov, G. A.; Manukhin, B. N.; Rakić, Ljubisav; Turpaev, T. M.

doi:10.1007/978-1-4684-3836-9_28

Cited by 3 publications

(1 citation statement)

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“…In summary, it can be concluded from the results of the present work and other investi gations of our laboratory [2,3] that the cells of early sea urchin embryos contain several physiologically active, low-molecular-weight substances identical with or related to neuro transmitters of adult animals: serotonin, tryptamine (or N-substitutcd derivative tryptamine), dopamine and acetylcholine. All of these substances may be intracellular regula tors of early embryogenic processes.…”

Section: Discussionmentioning

confidence: 83%

Biogenic Monoamines in Early Embryos of Sea Urchins

Manukhin¹,

Volina²,

Markova³

et al. 1981

Dev Neurosci

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Indolylalkylamine determination was performed on the eggs and embryos of six species of sea urchins, using several fluorometric techniques, including the fluorescence of a substance itself and the fluorescence of its condensation products after treatment with orthophthaldialdehyde and ninhydrin. The serotonin-like substance of sea urchin embryos as well as of adults was shown to consist of at least two components, of which the major one is tryptamine or its derivative with a substituting group at aminonitrogen. Further, serotonin was found to be present at all developmental stages investigated, although at much lower concentrations. The results of this study suggest a regulatory role of ''prenervous'' tryptamine in the early embryogenesis of the sea urchin.

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Section: Discussionmentioning

confidence: 83%