Early Results of Unilateral Prostatic Artery Embolization as a Focal Therapy in Patients with Prostate Cancer under Active Surveillance: Cancer Prostate Embolisation, a Pilot Study

Frandon, Julien; Bey, E.; Hamard, Aymeric; Mohammad, Hélène; Gonzalez, S.; Greffier, Joël; Chevallier, Thierry; Forges, Hélène de; Beregi, Jean‐Paul; Droupy, S.

doi:10.1016/j.jvir.2020.10.002

Cited by 16 publications

(5 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Patients in the following categories were included in the study: subjects meeting the diagnosis criteria for PCa in Diagnosis and Treatment Specifications for Prostate Cancer [7], and were diagnosed after pathological biopsy of the prostate, with clinical manifestations such as micturition urgency, hematuria, and frequent micturition; patients with NM stages of T1 and T2, without symptoms of clinical metastasis and local lymphadenectasis; subjects who were treated in ICU, and those who did not receive hormonal and immuno-related therapies before the present study.…”

Section: Inclusion Criteriamentioning

confidence: 99%

Effect of combined use of atorvastatin and hormonal therapy on serum prostate-specific antigen, urinary function, and quality of life of early prostate cancer patients in intensive care unit

Li¹,

Liao²

2022

Trop. J. Pharm Res

View full text Add to dashboard Cite

Purpose: To determine the effects of combined use of atorvastatin and hormonal therapy on serum levels of prostate-specific antigen (PSA), urinary function parameters, and quality of life (QOL) of intensive care unit (ICU) patients with early prostate cancer (PCa). Methods: The clinical data for 90 PCa patients treated in ICU of Chenzhou First People's Hospital, Chenzhou, China from July 2019 to July 2020 were retrospectively analyzed. The patients were divided into a reference group given intensity-modulated radiotherapy (n = 45), and a study group treated with intensity-modulated radiotherapy + atorvastatin + hormonal therapy (n = 45) sequentially as they were admitted. After the treatments, serum PSA levels of the patients were measured using enzyme-linked immunosorbent assay (ELISA), while QOL was measured based on Expanded Prostate Cancer Index Composite (EPIC). Urinary parameters were determined by measuring various urodynamic indicators. Results: Compared with the reference group, the study group had significantly lower post-treatment serum levels of PSA and blood lipids, higher levels of urinary function indicators (except for residual urine volume), and higher scores in IIEF-5 and EPIC (p < 0.001). Conclusion: These results demonstrate that the combined use of atorvastatin and hormonal therapy is a reliable method for improving urinary function and QOL in early PCa patients. Moreover, the combined treatment has potentials for reducing serum levels of PSA and blood lipids in PCa patients. These findings may be useful in the establishment of improved therapy for early PCa. Keywords: Atorvastatin; Hormonal therapy; Early prostate cancer; Serum PSA; Urinary function; Quality of life

show abstract

Section: Inclusion Criteriamentioning

confidence: 99%

Effect of combined use of atorvastatin and hormonal therapy on serum prostate-specific antigen, urinary function, and quality of life of early prostate cancer patients in intensive care unit

Li¹,

Liao²

2022

Trop. J. Pharm Res

View full text Add to dashboard Cite

show abstract

“…Vascular territory-based therapy is performed by IRs only. As opposed to focal ablative therapy, it enables treatment in difficult-to-access regions including anterior and apical zones, and lowers the risk of metachronous CsPCa in the remaining prostatic tissue, as lower grade lesions in the treated area are also exposed to treatment induced ischemia [ 43 ]. A retrospective analysis of tumor-related pathologic angiographic findings in patients with PCa reported arteriovenous fistula (AVF) in 10% of cases, representing a potential risk of nontarget embolization [ 44 ].…”

Section: Endovascular Treatmentsmentioning

confidence: 99%

“…A retrospective analysis of tumor-related pathologic angiographic findings in patients with PCa reported arteriovenous fistula (AVF) in 10% of cases, representing a potential risk of nontarget embolization [ 44 ]. A recent case series evaluated the feasibility of PAE in 10 patients with low-risk PCa under AS [ 43 ]. Unilateral PAE was performed using 300–500-μm microspheres aiming for locoregional ischemia in the affected prostatic lobe.…”

Section: Endovascular Treatmentsmentioning

confidence: 99%

Minimally Invasive Procedures in the Diagnosis and Treatment of Localized Prostate Cancer: an Interventional Radiologist’s Perspective

et al. 2022

View full text Add to dashboard Cite

Purpose of Review Minimal invasive procedures, including targeted biopsy (TB) and focal therapy (FT), are increasingly used in diagnosis and treatment of localized prostate cancer. Here, we review the current role of these procedures, from a perspective of an interventional radiologist. Recent Findings TB is an established part of current guidelines for diagnosis of PCa. Several modalities of FT are gaining prevalence in recent years, as a tissue-preserving alternative for definitive treatment of localized PCa. FT is currently at early research stages, offered to selected patients in clinical trials settings. Summary TB and FT are minimally invasive procedures used by multidisciplinary teams for diagnosis and treatment of localized PCa.

show abstract

“…The efficacy of prostatic artery embolization (PAE) relies on accurate identification of the prostatic artery, which can be technically challenging, and nontarget ischemia of adjacent tissue can result. The role of PAE in symptom reduction was evaluated in three studies [33,36 ▪ ,37 ▪ ] (Table 1). All reported a reduction in the mean International Prostate Symptom Score (IPSS) score ranging from 4 to 21 points from baseline.…”

Section: Prostate Cancermentioning

confidence: 99%

The role of surgery for loco-regional and advanced urological cancers

Chow

Tay

Yuen

et al. 2022

Current Opinion in Urology

View full text Add to dashboard Cite

Purpose of reviewThere is a general misconception that surgery is the antithesis of palliation. However, symptom mitigation, the basic tenet of palliative interventions, can be achieved by invasive procedures. Surgical care, thus, plays an important role in palliative oncology, alongside radiation and systemic therapy. There is global movement to improve palliation in oncology, and thus it is timely to evaluate the role of surgical interventions can play in this setting. Recent findingsMany of the surgical interventions done with palliative intent were first established as curative options. Most studies looked at interventions for local control of primary tumour including extirpative surgeries, while some studies studied pain relief for bone metastases. Results show that patients have an acceptable survival outcome and complication rate comparable to those done in the curative setting. However, not all studies report functional outcomes and symptom-relief consistently, highlighting an unmet need. SummaryMore studies are needed to further define the role of surgery in palliative care. Randomized controlled trials studying surgical intervention in the palliative setting will be challenging because of lack of equipoise, inherent bias in patient and disease characteristics in those who undergo surgery. Nonetheless, studies should endeavour to study symptom-free survival and PROMs as meaningful endpoints of interventions performed in a palliative setting rather than solely focus on hard oncological endpoints of survival.

show abstract

Early Results of Unilateral Prostatic Artery Embolization as a Focal Therapy in Patients with Prostate Cancer under Active Surveillance: Cancer Prostate Embolisation, a Pilot Study

Cited by 16 publications

References 34 publications

Effect of combined use of atorvastatin and hormonal therapy on serum prostate-specific antigen, urinary function, and quality of life of early prostate cancer patients in intensive care unit

Effect of combined use of atorvastatin and hormonal therapy on serum prostate-specific antigen, urinary function, and quality of life of early prostate cancer patients in intensive care unit

Minimally Invasive Procedures in the Diagnosis and Treatment of Localized Prostate Cancer: an Interventional Radiologist’s Perspective

The role of surgery for loco-regional and advanced urological cancers

Contact Info

Product

Resources

About