Early Results of Clinical Application of Autologous Whole Bone Marrow Stem Cell Transplantation for Critical Limb Ischemia with Buerger’s Disease

Abstract

Our goal was to evaluate early results of the clinical application of autologous whole bone marrow stem cell transplantation (AWBMSCT) for critical limb ischemia (CLI) in patients with Buerger’s disease. We retrospectively analyzed the data of 58 limbs of 37 patients (mean age, 43.0 years; range, 28–63 years; male, 91.9%) with Buerger’s disease with CLI who were treated with AWBMSCT from March 2013 to December 2014. We analyzed Rutherford category, pain score, pain-free walking time (PFWT), total walking time (TWT), ankle brachial pressure index (ABPI), and toe brachial pressure index (TBPI), and investigated wound healing and occurrence of unplanned amputations. The mean follow-up duration was 11.9 ± 7.2 months (range, 0.9–23.9 months) and 100%, 72.4%, and 74.1% of patients were available to follow-up 1, 3 and 6 months after AWBMST, respectively. At 6 months, patients demonstrated significant improvements in Rutherford category (P < 0.0001), pain score (P < 0.0001), PFWT (P < 0.0001) and TBPI (P < 0.0001). ABPI was increased compared to baseline, but the difference was not significant. A total of 76.5% ischemic wounds achieved complete or improved healing. AWBMSCT is a safe and effective alternative or adjunctive treatment modality to achieve clinical improvement in patients with CLI.

Autologous Peripheral Blood-derived Stem Cells Transplantation for Treatment of no-option Angiitis-induced Critical Limb Ischemia: 10-year Management Experience

“…Several previous clinical studies have demonstrated the bene cial effect of SCT on limb salvage and ulcer healing in NO-AICLI compared with placebo intervention [20,21,[30][31][32]. More recent data reported by Gu et al suggested that the 10-year amputation-free survival was 85.3% in patients with TAO treated by BMMNCs, similar with the long-term MAFS in this study [33].…”

Autologous peripheral blood-derived stem cells transplantation for treatment of no-option angiitis-induced critical limb ischemia: 10-year management experience

“…Several previous clinical studies have demonstrated the bene cial effect of SCT on limb salvage and ulcer healing in NO-AICLI compared with placebo intervention [20,21,[30][31][32]. More recent data reported by Gu et al suggested that the 10-year amputation-free survival was 85.3% in patients with TAO treated by BMMNCs, similar with the long-term MAFS in this study [33].…”

Mineral-Coated Microparticles Enhance mRNA-Based Transfection of Human Bone Marrow Cells

“…The other 99% of bone marrow cells 5 are likely to play an important role in tissue regeneration 6, 7. For instance, delivery of bone marrow cells was found to be conducive to angiogenesis because of the presence of vascular cells,8, 9 and the high concentration of white blood cells in marrow can impart anti-inflammatory properties because they secrete high levels of interleukin-1 receptor antagonist (IL-1ra) 5, 10. However, it remains challenging to control the effects of such a vast array of different cell types and to achieve consistency in therapeutic outcomes.…”