Abstract:We herein report the case of a 36-year-old man who died suddenly after a fight with another man. Forensic investigations included unenhanced computed tomography, postmortem angiography, autopsy, histology, neuropathology, toxicology, and biochemistry and allowed a traumatic cause of death to be excluded. An electrocardiogram recorded some years prior to death revealed the presence of an early repolarization pattern. Based on the results of all investigations, the cause of death was determined to be cardiac arr… Show more
“…Numerous studies have investigated the pathways by which psychological stress and emotional upset lead to sudden death [12,44,45]. However, the mechanisms underlying psychological stress and SCD have not been precisely identified.…”
Section: Discussionmentioning
confidence: 99%
“…A recent report summarized the various possible pathways by which psychological stress and emotional upset may lead to sudden death [12]. The psychosocial stress-induced neurovegetative changes include the hemodynamic response, autonomic alterations, and neuroendocrine activation as well as inflammatory and prothrombotic responses, all of which are known to have negative influences on the cardiovascular system [1] and may be responsible for the malignant arrhythmia-induced death during psychosocially stressful events [12].…”
Section: Introductionmentioning
confidence: 99%
“…The psychosocial stress-induced neurovegetative changes include the hemodynamic response, autonomic alterations, and neuroendocrine activation as well as inflammatory and prothrombotic responses, all of which are known to have negative influences on the cardiovascular system [1] and may be responsible for the malignant arrhythmia-induced death during psychosocially stressful events [12]. However, the mechanisms underlying psychological stress and emotional upset, such as acute restraint stress (ARS)-related SCD, have not yet been pinpointed.…”
Section: Introductionmentioning
confidence: 99%
“…Even with advanced first responder systems, only $5% of those who suffer out-of-hospital cardiac arrest will ultimately survive [14,15]. Ventricular tachycardia (VT) and ventricular fibrillation (VF), are major causes of SCD [15][16][17], along with various arrhythmogenic factors such as left ventricular hypertrophy (LVH) [17], abnormalities in autonomic tone [18] and acute psychosocial stress [12]. LVH due to hypertension is characterized by several electro-physiological abnormalities including prolonged duration of the action potential, decreased resting membrane potential, heterogeneous recovery following depolarization and slowed conduction velocity [17][18][19][20].…”
“…Numerous studies have investigated the pathways by which psychological stress and emotional upset lead to sudden death [12,44,45]. However, the mechanisms underlying psychological stress and SCD have not been precisely identified.…”
Section: Discussionmentioning
confidence: 99%
“…A recent report summarized the various possible pathways by which psychological stress and emotional upset may lead to sudden death [12]. The psychosocial stress-induced neurovegetative changes include the hemodynamic response, autonomic alterations, and neuroendocrine activation as well as inflammatory and prothrombotic responses, all of which are known to have negative influences on the cardiovascular system [1] and may be responsible for the malignant arrhythmia-induced death during psychosocially stressful events [12].…”
Section: Introductionmentioning
confidence: 99%
“…The psychosocial stress-induced neurovegetative changes include the hemodynamic response, autonomic alterations, and neuroendocrine activation as well as inflammatory and prothrombotic responses, all of which are known to have negative influences on the cardiovascular system [1] and may be responsible for the malignant arrhythmia-induced death during psychosocially stressful events [12]. However, the mechanisms underlying psychological stress and emotional upset, such as acute restraint stress (ARS)-related SCD, have not yet been pinpointed.…”
Section: Introductionmentioning
confidence: 99%
“…Even with advanced first responder systems, only $5% of those who suffer out-of-hospital cardiac arrest will ultimately survive [14,15]. Ventricular tachycardia (VT) and ventricular fibrillation (VF), are major causes of SCD [15][16][17], along with various arrhythmogenic factors such as left ventricular hypertrophy (LVH) [17], abnormalities in autonomic tone [18] and acute psychosocial stress [12]. LVH due to hypertension is characterized by several electro-physiological abnormalities including prolonged duration of the action potential, decreased resting membrane potential, heterogeneous recovery following depolarization and slowed conduction velocity [17][18][19][20].…”
“…Acute emotional distress (especially anger-like stress) may provoke ventricular arrhythmia, as well as acute myocardial infarction [37,38], but stress due to assault [39] or natural disasters are reported as triggers for SCD, as well [40]. 20 to 40% of sudden cardiac deaths may be precipitated by acute emotional stressors.…”
Background and aims: Internet gaming disorder (IGD) is an emerging problem. Rarely, media reports about people, who have died during playing video games, but thus far no systematic, scientific study is available about the topic. We investigated such cases, looking for common characteristics, connection between gaming and death, and the possible reasons leading to death.Methods: Cases were collected through internet search with general keywords, with ones specific to identified cases, and by working along cross references.Results: 24 cases were found: one from 1982, the others between 2002 and 2021. Twenty-three of the victims were male, age ranged from 11 to 40 years. More than half of the cases originated from Southeast Asia, and 12 deaths happened in internet cafes. Gamers played action-rich multiplayer games. In 18 cases the gaming session before death was extremely long (around a day or even several days) with minimal rest. The cause of death was pulmonary embolism in 5 cases, cerebral hemorrhage in 2 cases, most of the rest was presumably due to fatal cardiac arrhythmia.Discussion: Long sedentary position and dehydration may precipitate thromboembolism, acute blood pressure elevation during gaming may promote cerebral hemorrhage, and several factors (including acute and chronic sleep deprivation, exhaustion, stress) can lead to acute autonomic dysfunction and fatal arrhythmia. Conclusion: Incidence of non-violent death cases linked to playing video games is presumably very low. It mostly occurs in young males and it is often characterized by extremely long gaming time.
Stress refers to a series of neuroendocrine reactions, such as sympathetic nerve excitation and pituitary-adrenal cortex secretion increase, which occur when the body is stimulated by various stressors, and the changes of various functions and metabolism caused by these reactions. Chronic fatigue stress is a fatigue state caused by long-term physical and psychological stress. When the stress reaches a certain intensity or the individual is not well-tolerated, the body stability is impaired, resulting in various pathophysiological reactions leading to various diseases, such as stress hyperglycemia, stress cardiomyopathy, stress arrhythmia, stress ulcer hemorrhagic shock, or even stress ulcer hemorrhagic shock. Eventually lead to sudden death and other adverse events.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.