Early renal insufficiency and late venous thromboembolism after renal transplantation in the united states

Abbott, Kevin C.; Cruess, David F.; Agodoa, Lawrence Y.; Sawyers, Eric S.; Tveit, Daniel P.

doi:10.1053/j.ajkd.2003.08.047

Cited by 55 publications

(48 citation statements)

References 23 publications

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“…Similarly, Abbott et al 9 reported that the incidence rate of VTE in a cohort of 28,924 Medicare renal transplant patients was 9.8 events per 1000 person-years; those with renal insufficiency (eGFR Ͻ30 ml/min per 1.73 m 2 ) at 1 yr after renal transplantation had a two-fold higher risk for VTE compared with those with eGFR Ͼ30 ml/ min per 1.73 m 2 . Our study seems to be the first to report an association between mildly decreased kidney function and stage 3/4 CKD and VTE in the general population.…”

Section: Discussionmentioning

confidence: 99%

“…6,7 Furthermore, epidemiologic studies have reported an increased risk for VTE in dialysis 8 and in renal transplant patients. 9 To our knowledge, CKD has not been evaluated as a risk factor for VTE in the general population. If an association were found, then this would increase understanding of VTE etiology and identify a subset of the population at high risk for possible prophylaxis.…”

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confidence: 99%

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Chronic Kidney Disease Increases Risk for Venous Thromboembolism

Wattanakit

Cushman

Stehman‐Breen

et al. 2008

Journal of the American Society of Nephrology

289

160

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Chronic kidney disease (CKD) is associated with increased risk for cardiovascular disease morbidity and mortality, but its association with incident venous thromboembolism (VTE) in non-dialysis-dependent patients has not been evaluated in a community-based population. With the use of data from the Longitudinal Investigation of Thromboembolism Etiology (LITE) study, 19,073 middle-aged and elderly adults were categorized on the basis of estimated GFR, and cystatin C (available in 4734 participants) was divided into quintiles. During a mean follow-up time of 11.8 yr, 413 participants developed VTE. Compared with participants with normal kidney function, relative risk for VTE was 1.28 (95% confidence interval [CI] 1.02 to 1.59) for those with mildly decreased kidney function and 2.09 (95% CI 1.47 to 2.96) for those with stage 3/4 CKD, when adjusted for age, gender, race, and center. After additional adjustment for cardiovascular disease risk factors, an increased risk for VTE was still observed in participants with stage 3/4 CKD, with a multivariable adjusted relative risk of 1.71 (95% CI 1.18 to 2.49). There was no significant association between cystatin C and VTE. In conclusion, middle-aged and elderly patients with CKD (stages 3 through 4) are at increased risk for incident VTE, suggesting that VTE prophylaxis may be particularly important in this population.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Chronic Kidney Disease Increases Risk for Venous Thromboembolism

Wattanakit

Cushman

Stehman‐Breen

et al. 2008

Journal of the American Society of Nephrology

289

160

View full text Add to dashboard Cite

show abstract

“…6 Notably, numerous epidemiological studies have shown that patients with all stages of CKD experience higher rates of atherothrombotic disease manifestations and processes with thromboembolic potential such as atrial fibrillation than the general population. [7][8][9][10] This underscores the importance of antithrombotic treatment strategies in these patients. However, the risk-tobenefit ratio with antithrombotic therapies may be altered in CKD.…”

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confidence: 99%

Antithrombotic Therapy in Patients With Chronic Kidney Disease

2012

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“…We also studied congestive heart failure, atrial fibrillation, and venous thromboembolism as cardiovascular diagnoses that have been associated with morbidity and mortality after transplantation (12,15,16,26). Along with diagnoses, we studied several cardiovascular procedures tracked in the WU-KTDB: Cardiac catheterization, coronary artery bypass grafting, amputation, and revascularization of peripheral vascular disease.…”

Section: Measures Of Cardiovascular Diagnoses and Proceduresmentioning

confidence: 99%