Early relaxation time assessment for characterization of breast tissue and diagnosis of breast tumors

Baghban, M.; Mojra, Afsaneh

doi:10.1016/j.jmbbm.2018.07.037

Cited by 14 publications

(5 citation statements)

References 30 publications

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“…Indeed, beyond studying the mechanotransduction pathways responsible for viscoelasticitymediated cancer progression, there are some studies on the potential use of viscoelasticity parameters as cancer biomarkers [7,8,186,187]. In some cases, these studies rely on machine learning and artificial intelligence algorithms to analyze datasets and classify tumors.…”

Section: Concluding Remarks and Future Perspectivesmentioning

confidence: 99%

“…Using a Gaussian mixture model, they could distinguish between normal, benign, and malignant breast biopsy tissues using the elasticity, fluidity, and viscosity parameters. Baghban and Mojra [187] used non-penetrating indentation in vivo to study the relaxation time of breast tissue in patients with breast cancer. The authors fitted the data to a generalized Maxwell model with two Maxwell elements and found that the first relaxation time could differentiate between the presence of a tumor, with its magnitude being up to six times that of healthy tissue.…”

Section: Concluding Remarks and Future Perspectivesmentioning

confidence: 99%

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Beyond stiffness: deciphering the role of viscoelasticity in cancer evolution and treatment response

Zubiarrain-Laserna,

Martínez-Moreno,

López de Andrés

et al. 2024

Biofabrication

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There is increasing evidence that cancer progression is linked to tissue viscoelasticity, which challenges the commonly accepted notion that stiffness is the main mechanical hallmark of cancer. However, this new insight has not reached widespread clinical use, as most clinical trials focus on the application of tissue elasticity and stiffness in diagnostic, therapeutic, and surgical planning. Therefore, there is a need to advance the fundamental understanding of the effect of viscoelasticity on cancer progression, to develop novel mechanical biomarkers of clinical significance. Tissue viscoelasticity is largely determined by the extracellular matrix (ECM), which can be simulated in vitro using hydrogel-based platforms. Since the mechanical properties of hydrogels can be easily adjusted by changing parameters such as molecular weight and crosslinking type, they provide a platform to systematically study the relationship between ECM viscoelasticity and cancer progression. This review begins with an overview of cancer viscoelasticity, describing how tumor cells interact with biophysical signals in their environment, how they contribute to tumor viscoelasticity, and how this translates into cancer progression. Next, an overview of clinical trials focused on measuring biomechanical properties of tumors is presented, highlighting the biomechanical properties utilized for cancer diagnosis and monitoring. Finally, this review examines the use of biofabricated tumor models for studying the impact of ECM viscoelasticity on cancer behavior and progression and it explores potential avenues for future research on the production of more sophisticated and biomimetic tumor models, as well as their mechanical evaluation.

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Section: Concluding Remarks and Future Perspectivesmentioning

confidence: 99%

Section: Concluding Remarks and Future Perspectivesmentioning

confidence: 99%

Beyond stiffness: deciphering the role of viscoelasticity in cancer evolution and treatment response

Zubiarrain-Laserna,

Martínez-Moreno,

López de Andrés

et al. 2024

Biofabrication

View full text Add to dashboard Cite

show abstract

“…[ 125 ] Likewise, examination of viscoelastic behavior of the breast may supplement traditional diagnostic methods and assist breast disease diagnosis. [ 126–128 ] Given the above, study on viscoelastic performances of the tissues may not only help to better understand the mechanisms of regulating physiological activities, tissue homeostasis, and disease progression but also offer new strategies for future disease diagnosis and therapy in clinic.…”

Section: Viscoelasticity: An Important Dynamic Mechanical Characteristicmentioning

confidence: 99%

Viscoelastic Cell Microenvironment: Hydrogel‐Based Strategy for Recapitulating Dynamic ECM Mechanics

Han

Yang

et al. 2021

Adv Funct Materials

121

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The native extracellular matrix (ECM) generally exhibits dynamic mechanical properties and displays time‐dependent responses to deformation or mechanical loading, in terms of viscoelastic behaviors (e.g., stress relaxation and creep). Viscoelasticity of the ECM plays a critical role in development, homeostasis, and tissue regeneration, and its implication in disease progression has also been recognized recently. Hydrogels with tunable viscoelastic properties hold a great promise to recapitulate such time‐dependent mechanics found in native ECM, which have been recently used to regulate cell behavior and guide cell fate. Here the importance of tissue viscoelasticity is first highlighted, the molecular mechanisms of hydrogel viscoelasticity are summarized, and characterization techniques used at the macroscale and microscale are reviewed. Then, recent advances in developing novel hydrogels with tunable viscoelasticity through varying crosslinking strategies, engineering of viscoelastic cell microenvironment and its substantial effects on cell behavior and fate are described, and the underlying mechanobiology mechanisms are subsequently discussed. Finally, the ongoing challenges and future perspectives on the design and modulation of viscoelastic hydrogels and the mechanobiology mechanisms on cellular responses to viscoelastic cell microenvironment are proposed.

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“…In addition to polymer engineering and science, viscoelastic properties have important applications in many other fields. For example, the viscoelastic properties can be served as quantities to differentiate normal and pathological tissues in clinical diagnosis [ 7 , 15 , 16 , 17 , 18 , 19 , 20 , 21 ], to evaluate the functional statuses of engineered tissues in tissue engineering [ 22 , 23 , 24 ], to understand the conditions of cells and the disease evolutions in biological and medical sciences [ 25 , 26 ], and so on. For successful applications of viscoelastic properties, it is an important issue regarding how to accurately evaluate them.…”

Section: Introductionmentioning

confidence: 99%

Constitutive Equations for Analyzing Stress Relaxation and Creep of Viscoelastic Materials Based on Standard Linear Solid Model Derived with Finite Loading Rate

et al. 2022

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The viscoelastic properties of materials such as polymers can be quantitatively evaluated by measuring and analyzing the viscoelastic behaviors such as stress relaxation and creep. The standard linear solid model is a classical and commonly used mathematical model for analyzing stress relaxation and creep behaviors. Traditionally, the constitutive equations for analyzing stress relaxation and creep behaviors based on the standard linear solid model are derived using the assumption that the loading is a step function, implying that the loading rate used in the loading process of stress relaxation and creep tests is infinite. Using such constitutive equations may cause significant errors in analyses since the loading rate must be finite (no matter how fast it is) in a real stress relaxation or creep experiment. The purpose of this paper is to introduce the constitutive equations for analyzing stress relaxation and creep behaviors based on the standard linear solid model derived with a finite loading rate. The finite element computational simulation results demonstrate that the constitutive equations derived with a finite loading rate can produce accurate results in the evaluation of all viscoelastic parameters regardless of the loading rate in most cases. It is recommended that the constitutive equations derived with a finite loading rate should replace the traditional ones derived with an infinite loading rate to analyze stress relaxation and creep behaviors for quantitatively evaluating the viscoelastic properties of materials.

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Early relaxation time assessment for characterization of breast tissue and diagnosis of breast tumors

Cited by 14 publications

References 30 publications

Beyond stiffness: deciphering the role of viscoelasticity in cancer evolution and treatment response

Beyond stiffness: deciphering the role of viscoelasticity in cancer evolution and treatment response

Viscoelastic Cell Microenvironment: Hydrogel‐Based Strategy for Recapitulating Dynamic ECM Mechanics

Constitutive Equations for Analyzing Stress Relaxation and Creep of Viscoelastic Materials Based on Standard Linear Solid Model Derived with Finite Loading Rate

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