Early recurrence of hepatitis C virus infection after liver transplantation

Petrovic, Lydia M.

doi:10.1002/lt.20942

Cited by 31 publications

(23 citation statements)

References 34 publications

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“…There are also important interactions with other graft complications, particularly rejection, which may produce complex histological changes that are difficult to interpret. The distinction between HCV infection and rejection as a cause for graft dysfunction continues to be a major problem clinically [72][73][74]. Noninvasive methods are not reliable in making the distinction and this therefore remains a common indication for liver biopsy.…”

Section: Recurrent Hepatitis Cmentioning

confidence: 99%

Current views on rejection pathology in liver transplantation

Neil¹,

Hübscher²

2010

Transplant International

131

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Section: Recurrent Hepatitis Cmentioning

confidence: 99%

Current views on rejection pathology in liver transplantation

Neil¹,

Hübscher²

2010

Transplant International

131

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“…HCV infection is the most common indication for OLT, and disease recurrence in the allograft is among the leading causes of graft loss and the need for re-transplantation 62 63 88 89 90 91 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116. Viral recurrence is universal and graft injury occurs routinely.…”

Section: Disease Recurrencementioning

confidence: 99%

Liver allograft pathology: approach to interpretation of needle biopsies with clinicopathological correlation

2009

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The spectrum of diseases encountered in post-transplant liver pathology biopsies is broad. In this review, these have been divided as belonging to one of three categories: (1) new-onset/de novo post-transplant abnormalities (early and late), (2) rejection, and (3) recurrence of original disease. The clinical and pathological features of the entities making up each category, with the relevant differential diagnosis and overlaps between and within these groups, are discussed and illustrated. Recurrent or de novo neoplasms make up a fourth category not included in this review. Early new-onset conditions are mostly related to surgical complications, donor factors and ischaemia to the graft. These include reperfusion/preservation injury, lipopeliosis, small-for-size-syndrome, biliary sludge syndrome and hepatic artery thrombosis. The various forms of rejection (cellular, chronic, antibody-mediated, and late atypical rejection) are detailed. Most chronic liver diseases can and do recur in the graft. They may display features that overlap with de novo conditions (eg, primary sclerosing cholangitis versus chronic rejection). As with most cases of allograft biopsy interpretation, accurate diagnosis rests with careful correlation of histological features with clinical, imaging and laboratory findings, and often comparison with previous sequential and follow-up biopsies. Late-onset new diseases include biliary strictures, idiopathic chronic hepatitis and de novo autoimmune hepatitis, among others. This review provides a practical approach to the interpretation of these challenging biopsies. Selected difficult scenarios or conundrums are identified and discussed in the relevant sections.

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“…Two large studies have shown that the incidence and severity of hepatitis C recurrence do not differ between DDLT and LDLT recipients; however another study has found that the incidence of cholestatic hepatitis is significantly greater in LDLT recipients [24,27,28] . Several studies have identified a number of potential risk factors for recurrent hepatitis C infection including hepatitis C virus related factors (virus load, genotype) as well as coinfection with other viruses such as cytomegalovirus, hepatitis B virus and hepatitis D virus [29] . There are still no welldefined parameters that would predict which patients are at risk to develop recurrent hepatitis C and those who will not.…”

Section: Recurrent Viral Hepatitismentioning

confidence: 99%

Liver transplantation: Yesterday, today and tomorrow

Abbasoğlu¹

2008

WJG

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With the advances in technical skills, management of postoperative complications and improvements in immunosuppressive drugs, liver transplantation is the standard treatment for many patients with chronic liver disease. Today, shortage of donor organs seems to be the major limiting factor for the application of liver transplantation. This review focuses on five issues that are challenging to clinical practice of liver transplantation and relevant to gastroenterologists. These include living donor liver transplantation, recurrent viral hepatitis, non-heart-beating donors, hepatocellular carcinoma, and ABO incompatible liver transplantation. Living donor and non-heart beating donor transplantations were initiated as a solution to increase the donor organ pool and it is expected that there will be an increase in the number of these donors. Recurrent hepatitis C and hepatocellular carcinoma following liver transplantation are among major problems and ongoing research in these diseases may lead to better outcomes in these recipients.

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Early recurrence of hepatitis C virus infection after liver transplantation

Cited by 31 publications

References 34 publications

Current views on rejection pathology in liver transplantation

Current views on rejection pathology in liver transplantation

Liver allograft pathology: approach to interpretation of needle biopsies with clinicopathological correlation

Liver transplantation: Yesterday, today and tomorrow

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