Early Recurrence after Surgical Resection in Patients with Pathological Stage I Non-small Cell Lung Cancer

Kawachi, Riken; Tsukada, Hiroko; Nakazato, Yoko; Takei, Hidefumi; Furuyashiki, Go; Koshiishi, Yoshihiko; Goya, Tomoyuki

doi:10.1055/s-0029-1185734

Cited by 31 publications

(19 citation statements)

References 5 publications

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“…However, three studies were not included in final meta-analysis due to insufficient survival information [17], [53] or overlap between cohorts [10], [11]. Eight studies reported the significant prognostic role of BVI for RFS by multivariate analysis [8], [9]–[11], [13]–[15], [19], [60], and two identified BVI as not significant for RFS [18], [54].…”

Section: Resultsmentioning

confidence: 99%

“…Usually, HRs and 95% confidence intervals (CIs) were directly obtained from published literatures using univariate [8]–[11], [13]–[15], [18], [19] or multivariate survival analyses. In some studies, BVI was determined to be an independent prognostic indicator using multivariate analysis; HRs and 95% CIs were generally reported [9], [10], [16], [18], [20], [21], [23], [26]–[29], [31], [33]–[36], [38], [40]–[45], [47]–[49], [52], [56]–[59], [60].…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Blood Vessel Invasion as a Strong Independent Prognostic Indicator in Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis

Wang

Chen

Chen³

et al. 2011

PLoS ONE

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Background and ObjectiveBlood vessel invasion plays a very important role in the progression and metastasis of cancer. However, blood vessel invasion as a prognostic factor for survival in non-small cell lung cancer (NSCLC) remains controversial. The aim of this study is to explore the relationship between blood vessel invasion and outcome in patients with NSCLC using meta-analysis.MethodsA meta-analysis of published studies was conducted to investigate the effects of blood vessel invasion on both relapse-free survival (RFS) and overall survival (OS) for patients with NSCLC. Hazard ratios (HRs) with 95% confidence intervals (95% CIs) were used to assess the strength of this association.ResultsA total of 16,535 patients from 52 eligible studies were included in the systematic review and meta-analysis. In total, blood vessel invasion was detected in 29.8% (median; range from 6.2% to 77.0%) of patients with NSCLC. The univariate and multivariate estimates for RFS were 3.28 (95% CI: 2.14–5.05; P<0.0001) and 3.98 (95% CI: 2.24–7.06; P<0.0001), respectively. For the analyses of blood vessel invasion and OS, the pooled HR estimate was 2.22 (95% CI: 1.93–2.56; P<0.0001) by univariate analysis and 1.90 (95% CI: 1.65–2.19; P<0.0001) by multivariate analysis. Furthermore, in stage I NSCLC patients, the meta-risk for recurrence (HR = 6.93, 95% CI: 4.23–11.37, P<0.0001) and death (HR = 2.15, 95% CI: 1.68–2.75; P<0.0001) remained highly significant by multivariate analysis.ConclusionsThis study shows that blood vessel invasion appears to be an independent negative prognosticator in surgically managed NSCLC. However, adequately designed large prospective studies and investigations are warranted to confirm the present findings.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Blood Vessel Invasion as a Strong Independent Prognostic Indicator in Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis

Wang

Chen

Chen³

et al. 2011

PLoS ONE

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“…Accurately predicting the cases in which disease is likely to recur can help guide the administration of adjuvant therapies, not only to those most likely to benefit from them, but also to prevent harmful treatment [4,5]. In addition to the TNM classification, tumor markers, such as CEA, have proven to be independent factors predicting the risk of recurrence as clinical parameters [6,7]. Despite a great deal of effort that has been made to identify prognostic markers following surgery, there is currently no consensus in clinical practice.…”

Section: Introductionmentioning

confidence: 99%

Epidermal Growth Factor Receptor-GEP100-Arf6 Axis Affects the Prognosis of Lung Adenocarcinoma

et al. 2014

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The overexpression of Arf6 and GEP100 is responsible for the invasive activity that is crucial for the activation of the epidermal growth factor receptor (EGFR) signaling pathways in human cancer. However, whether or not the expression of the EGFR-GEP100-Arf6 axis can be used as a biomarker for the prognosis of lung cancer has yet to be fully determined. Tumor specimens were collected from 182 patients who underwent a complete resection for lung adenocarcinoma. We analyzed phospho-EGFR (p-EGFR), GEP100, and Arf6 expression levels in the primary tumor by immunohistochemical analysis. The expression of p-EGFR, GEP100, and Arf6 was observed in 65 (35.7%), 95 (52.2%), and 20 (11.0%) patients, respectively. Significant associations between p-EGFR and GEP100 expression and vessel invasion were identified. The expression of these individual molecules was not associated with any statistically significant differences in survival. However, triple positive expression of p-EGFR, GEP100, and Arf6 was significantly associated with an increased risk of death based on the multivariate analysis. The EGFR-GEP100-Arf6 axis affected the prognosis of patients with primary lung adenocarcinoma. The combination of p-EGFR, GEP100, and Arf6 staining can predict the prognosis of patients after surgery.

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“…In our case, the G-CSF-producing metastatic tumor was detected only 8 months after pneumonectomy, although the pathological stage of the lung cancer was stage IB. This history suggests a poor prognosis because usually early recurrence within 1 year after surgical resection in patients with pathological stage I non-small cell lung cancer is rare and incidence is only 7.5% [16]. Furthermore, vertebral body and pelvic metastases were suspected in our case because of the uptake findings of the PET/CT scan; however, no symptoms of bone metastases were identified by CT.…”

Section: Discussionmentioning

confidence: 86%

Granulocyte-colony-stimulating factor-producing gastric metastasis from large cell type lung cancer

Yoshinaga

Kiyozaki

Okada

et al. 2010

Clin J Gastroenterol

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We report a case of granulocyte-colony-stimulating factor (G-CSF)-producing gastric metastasis from large cell type lung cancer. A 73-year-old man presented with severe anemia and leukocytosis that appeared 8 months after surgery for early lung cancer. Gastroendoscopy demonstrated a protruding circumscribed tumor with blood clot in the middle part of the stomach. The pathological finding from biopsy specimens revealed gastric metastasis of large cell carcinoma of the lung. Positron emission tomography/computed tomography demonstrated uptake in the bone; however, myeloid metastasis was negative with bone marrow biopsy. Serum level of G-CSF was elevated. We performed partial gastrectomy for hemostasis. After surgery, the hemoglobin, leukocyte count and serum level of G-CSF were within the expected normal limit. Immunohistological examination of G-CSF was positive in the resected specimen. The patient was discharged 22 days after the operation and has been followed up from 3 months after surgery to the present time. G-CSF-producing tumors have been reported to cause remarkable peripheral leukocytosis and neutrophil production in bone marrow. They have been reported in various types of malignancies and are usually associated with a poor prognosis.

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Early Recurrence after Surgical Resection in Patients with Pathological Stage I Non-small Cell Lung Cancer

Cited by 31 publications

References 5 publications

Blood Vessel Invasion as a Strong Independent Prognostic Indicator in Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis

Blood Vessel Invasion as a Strong Independent Prognostic Indicator in Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis

Epidermal Growth Factor Receptor-GEP100-Arf6 Axis Affects the Prognosis of Lung Adenocarcinoma

Granulocyte-colony-stimulating factor-producing gastric metastasis from large cell type lung cancer

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