Early radiographic osteoarthritis is associated with substantial changes in cartilage volume and tibial bone surface area in both males and females11Sources of support: National Health and Medical Research Council of Australia, Masonic Centenary Medical Research Foundation.

Jones, Graeme; Ding, Changhai; Scott, F; Glisson, Michael; Cicuttini, Flavia Maria

doi:10.1016/j.joca.2003.08.010

Cited by 236 publications

(79 citation statements)

References 14 publications

(22 reference statements)

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“…This situation can be easily monitored, however, and VC brought in at a later point to prove this case. It should be noted that the opposite case, where significant changes in tAB and ThCcAB.Me cause VC to show minimal change, may also be true and even more likely, because significant increases in tAB with aging have recently been reported in longitudinal studies (4,(29)(30)(31)(32).…”

Section: Discussionmentioning

confidence: 97%

An efficient subset of morphological measures for articular cartilage in the healthy and diseased human knee

Buck¹,

Wyman

Graverand

et al. 2010

Magn. Reson. Med.

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The relationship between three-dimensional, MRI-based morphologic measurements commonly taken of knee cartilage was examined to determine whether a subset of variables fully reflects differences observed in cartilage in cross-sectional and longitudinal studies. The benefits of a subset of measures include increased statistical power due to reduced multiple comparisons, improved understanding of relationships between the morphologic measures of articular knee cartilage, and greater efficiency in reporting results. One hundred fifty-two women (77 healthy and 75 with knee osteoarthritis) had coronal 3-T MR images of the knee acquired at baseline and at 24 months. Measures of femorotibial cartilage morphology (surface area, thickness, volume, etc.) were determined in the medial and lateral tibia and femur. Cartilage thickness (mean cartilage thickness over the total area of the [subchondral] bone), total subchondral bone area, and percentage of denuded area of the subchondral bone were found to explain over 90% of the cross-sectional and longitudinal variation observed in other measures of cartilage morphology commonly reported in knee osteoarthritis. Hence, these three measures of cartilage morphology explain nearly all variation in a larger set of common cartilage morphology measures both cross-sectionally and longitudinally, both in healthy and in osteoarthritic knees. These variables hence define an efficient subset for describing structural status and change in osteoarthritic cartilage. Magn Reson Med 63:680-690, 2010.V C 2010 Wiley-Liss, Inc.

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Section: Discussionmentioning

confidence: 97%

An efficient subset of morphological measures for articular cartilage in the healthy and diseased human knee

Buck¹,

Wyman

Graverand

et al. 2010

Magn. Reson. Med.

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“…When the first radiological changes on OA are detected, 13% of knee cartilage has already been lost (45). That loss of cartilage correlates with the worsening of symptoms and predicts knee replacement (46).…”

Section: Discussionmentioning

confidence: 99%

Knee Osteoarthritis: Condroprotector Action and Symptomatic Effect of Ozone on Pain, Function, Quality of Life, Minimal Joint Space and Knee Arthroplasty Delay

Fernández-Cuadros

Pérez-Moro

Albaladejo-Florín

2006

Middle East J Rehabil Health

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Objectives: To evaluate the effect of Ozone on pain, function, quality of life, minimal joint space and knee arthroplasty delay in a case series of patients with knee osteoarthritis (OA). Methods:Prospective quasi-experimental before-after study on 52 out of 120 patients with knee osteoarthritis (OA) Kellgren-Lawrence (K-L) grade 2 or more, who attended Santa Cristina's University Hospital, from January 2012 to June 2016. The Ozone protocol consisted of four sessions (1 session/week) of an intra-articular infiltration of a medical mixture of oxygen-ozone (95% -5%) at a 20 µg/mL concentration. Pain and quality of life (QoL) were measured by visual analogical scale (VAS) and western ontario and Mc master universities index for osteoarthritis (WOMAC), and minimal internal/external joint space width were measured by plain posterior-anterior weight-bearing knee radiographies at the beginning / end of treatment.Results: Mean age 70.36 years. Women 80.8% (n = 42), men 19.2% (n = 10). The severity of OA according to Kellgren-Lawrence scale was 3°(n = 36; 69.2%). Pain measured by VAS significantly decreased (P < 0.0001) from 8.1 to 2.5. The WOMAC-pain, WOMAC-stiffness and WOMAC-function subscales decreased significantly (P < 0.0001) from 16.5 to 4.9 points, 3.2 to 2 and 48 to 17.6, respectively. With respect to minimal joint space, the internal compartment measured 4.17 mm and increased significantly to 4.44 mm (P = 0.0003); while the external compartment was 6.02 mm and improved significantly to 6.26 mm (P = 0.0032) after the treatment protocol. After a mean of 10 months follow-up to a maximum of 28 months, none of knee OA patients underwent knee arthroplasty replacement. Conclusions:Ozone treatment is capable of producing pain relief, recovery of function and radiological improvement on minimal joint space in knee OA patients. Based on the results of our study, it is assumed that Ozone could slow/revert OA progression, due to the increase in the minimal internal and external joint space width. Ozone treatment delays the need for total knee arthroplasty.

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“…This study was performed as part of the Tasmanian Older Adult Cohort (TASOAC) study, a population-based study that was designed to identify the genetic, environmental, and biochemical factors associated with the development and progression of OA at multiple sites. Subjects between 50 and 80 years old were randomly selected from the electoral roll in Southern Tasmania (population 229, as previously described (17,18).…”

Section: Arthritis Care and Researchmentioning

confidence: 99%

“…Knee bone size measurement. Knee tibial plateau bone areas were measured using the software program Osiris as previously described (18). Medial and lateral tibial plateau bone areas were uniform in nature and can be measured directly from the reformatted axial images.…”

Section: Smokingmentioning

confidence: 99%

Patellofemoral Bone Marrow Lesions: Natural History and Associations With Pain and Structure

Zhu

Ding

Jin

et al. 2016

Arthritis Care & Research

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Early radiographic osteoarthritis is associated with substantial changes in cartilage volume and tibial bone surface area in both males and females11Sources of support: National Health and Medical Research Council of Australia, Masonic Centenary Medical Research Foundation.

Cited by 236 publications

References 14 publications

An efficient subset of morphological measures for articular cartilage in the healthy and diseased human knee

An efficient subset of morphological measures for articular cartilage in the healthy and diseased human knee

Knee Osteoarthritis: Condroprotector Action and Symptomatic Effect of Ozone on Pain, Function, Quality of Life, Minimal Joint Space and Knee Arthroplasty Delay

Patellofemoral Bone Marrow Lesions: Natural History and Associations With Pain and Structure

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