Early prenatal exposure to suspected endocrine disruptor mixtures is associated with lower IQ at age seven

Tanner, Eva M.; Hallerbäck, Maria Unenge; Wikström, Sverre; Lindh, Christian; Kiviranta, Hannu; Gennings, Chris; Bornehag, Carl‐Gustaf

doi:10.1016/j.envint.2019.105185

Cited by 137 publications

(70 citation statements)

References 79 publications

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“…of xenobiotics is the norm [107][108][109][110][111], and the health impacts of this mixture exposure during early life remain largely unknown, but effects on the human brain (i.e. decreased intelligence in children that were exposed prenatally to a mixture of EDCs) have been shown [21]). Approximately 12,000 intentionally added substances [67] and 30,000 to 100,000 non-intentionally added substances potentially migrate into food from various food contact articles [112].…”

Section: Risk Assessment Of Unknown Chemicals Is Not Possible Under Tmentioning

confidence: 99%

“…However, more recent scientific information demonstrates that this assumption is not generally valid, with the available evidence showing that exposure to low levels of endocrine disrupting chemicals can contribute to adverse health effects [14][15][16][17][18][19][20]. In addition, chemical mixtures can play a role in the development of adverse effects [21][22][23][24], and human exposure to chemical mixtures is the norm but currently not considered when assessing health impacts of FCCs [1]. The timing of exposures during fetal and child development is another critical aspect for understanding development of chronic disease [25].…”

Section: Introductionmentioning

confidence: 99%

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Impacts of food contact chemicals on human health: a consensus statement

et al. 2020

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Food packaging is of high societal value because it conserves and protects food, makes food transportable and conveys information to consumers. It is also relevant for marketing, which is of economic significance. Other types of food contact articles, such as storage containers, processing equipment and filling lines, are also important for food production and food supply. Food contact articles are made up of one or multiple different food contact materials and consist of food contact chemicals. However, food contact chemicals transfer from all types of food contact materials and articles into food and, consequently, are taken up by humans. Here we highlight topics of concern based on scientific findings showing that food contact materials and articles are a relevant exposure pathway for known hazardous substances as well as for a plethora of toxicologically uncharacterized chemicals, both intentionally and non-intentionally added. We describe areas of certainty, like the fact that chemicals migrate from food contact articles into food, and uncertainty, for example unidentified chemicals migrating into food. Current safety assessment of food contact chemicals is ineffective at protecting human health. In addition, society is striving for waste reduction with a focus on food packaging. As a result, solutions are being developed toward reuse, recycling or alternative (non-plastic) materials. However, the critical aspect of chemical safety is often ignored. Developing solutions for improving the safety of food contact chemicals and for tackling the circular economy must include current scientific knowledge. This cannot be done in isolation but must include all relevant experts and stakeholders. Therefore, we provide an overview of areas of concern and related activities that will improve the safety of food contact articles and support a circular economy. Our aim is to initiate a broader discussion involving scientists with relevant expertise but not currently working on food contact materials, and decision makers and influencers addressing single-use food packaging due to environmental concerns. Ultimately, we aim to support science-based decision making in the interest of improving public health. Notably, reducing exposure to hazardous food contact chemicals contributes to the prevention of associated chronic diseases in the human population.

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Section: Risk Assessment Of Unknown Chemicals Is Not Possible Under Tmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Impacts of food contact chemicals on human health: a consensus statement

et al. 2020

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“…There is convincing evidence that early-life EDC exposure is associated with impairments in executive brain functions, speed of information processing, verbal abilities, visual recognition memory, increased externalizing behaviors, and lower IQ scores [7][8][9][10]. This has been shown for single EDCs, but recently also within a mixture approach [20]. Thus, it is crucial that we establish test systems that are sensitive enough to detect ED-related effects in the range of relevant human exposures and to detect effects from human-relevant mixtures of EDCs in addition to effects from single compounds.…”

Section: Human-relevant Exposure To Edcsmentioning

confidence: 92%

“…Epigenetic patterns at specific loci can change in response to environmental factors [57] and this can potentially affect health, depending on cell type and developmental stage. Epidemiological data provides increasing evidence for associations between chemical exposures and epigenetic changes [20] and an increasing number of experimental studies show that early-life exposures to EDCs and other neurotoxic compounds induce epigenetic changes, in particular DNA methylation changes, which, in some cases, have been linked to modifications in brain morphology and to adversities later in life (such as changes in anxiety-like, exploratory, and social behaviors) [20,57]. Therefore, changes in epigenetic patterns might serve as biomarkers for adverse effects on developmental processes induced by EDCs, as well as other environmental factors.…”

Section: Identification Of Novel "Omics" Readoutsmentioning

confidence: 99%

The ENDpoiNTs Project: Novel Testing Strategies for Endocrine Disruptors Linked to Developmental Neurotoxicity

Lupu

Andersson

Bornehag

et al. 2020

IJMS

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Ubiquitous exposure to endocrine-disrupting chemicals (EDCs) has caused serious concerns about the ability of these chemicals to affect neurodevelopment, among others. Since endocrine disruption (ED)-induced developmental neurotoxicity (DNT) is hardly covered by the chemical testing tools that are currently in regulatory use, the Horizon 2020 research and innovation action ENDpoiNTs has been launched to fill the scientific and methodological gaps related to the assessment of this type of chemical toxicity. The ENDpoiNTs project will generate new knowledge about ED-induced DNT and aims to develop and improve in vitro, in vivo, and in silico models pertaining to ED-linked DNT outcomes for chemical testing. This will be achieved by establishing correlative and causal links between known and novel neurodevelopmental endpoints and endocrine pathways through integration of molecular, cellular, and organismal data from in vitro and in vivo models. Based on this knowledge, the project aims to provide adverse outcome pathways (AOPs) for ED-induced DNT and to develop and integrate new testing tools with high relevance for human health into European and international regulatory frameworks.

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“…Tanner, Hallerback, et al. (2020) used WQS to estimate the cumulative and individual impact of 26 prenatal EDC exposures and found that higher mixture levels were associated with lower IQ in boys at age 7 and that BPF, a BPA replacement compound, was the largest contributor.…”

Section: Complexities Of Exposuresmentioning

confidence: 99%

New directions in understanding the role of environmental contaminants in child development: Four themes

Trentacosta

Mulligan

2020

New Directions for Child and Adolescent Development

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Environmental contaminants, which include several heavy metals, persistent organic pollutants, and other harmful chemicals, impair several domains of child development. This article describes four themes from recent research on the impact of environmental contaminants on child development. The first theme, disparities in exposure, focuses on how marginalized communities are disproportionately exposed to harmful environmental contaminants. The second theme, complexity of exposures, encapsulates recent emphases on timing of exposures and mixtures of multiple exposures. The third theme, mechanisms that link exposures to outcomes, focuses on processes that elucidate how contaminants impact outcomes. The fourth theme, mitigating risks associated with exposures, sheds light on potential protective factors that could ameliorate many of the harmful effects of contaminant exposures. Developmental scientists are well positioned to contribute to interdisciplinary research that addresses these themes, which could foster additional conceptual and empirical innovations and inform policies and practices to mitigate risks and improve children's well-being. K E Y W O R D S child development, developmental science, environmental contaminants, environmental health, interdisciplinary research, lead exposure, toxicants The physical environment plays a critical role in human health and well-being across the lifespan. Unfortunately, exposure to harmful contaminants in the physical environment is nearly ubiquitous. Based on a recent estimate from the World Health Organization,

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Early prenatal exposure to suspected endocrine disruptor mixtures is associated with lower IQ at age seven

Cited by 137 publications

References 79 publications

Impacts of food contact chemicals on human health: a consensus statement

Impacts of food contact chemicals on human health: a consensus statement

The ENDpoiNTs Project: Novel Testing Strategies for Endocrine Disruptors Linked to Developmental Neurotoxicity

New directions in understanding the role of environmental contaminants in child development: Four themes

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