Early pregnancy metabolite profiling discovers a potential biomarker for the subsequent development of gestational diabetes mellitus

Early second-trimester plasma protein profiling using multiplexed isobaric tandem mass tag (TMT) labeling predicts gestational diabetes mellitus

“…Interestingly, several metabolomics studies also reported the potential biomarkers for GDM by using serum [44] or hair samples [45]. Metabolomics and proteomics, based on mass spectrometry, have been widely used for exploring early diagnosis markers.…”

Itaconic Acid: The Surprising Role of an Industrial Compound as a Mammalian Antimicrobial Metabolite

“…In line with this finding, itaconic acid has been found to be more abundant in the serum of pregnant women who subsequently developed diabetes when compared to controls with uncomplicated pregnancies. Therefore, the presence of itaconic acid may demonstrate a potential role of inflammation in early pregnancy in the development of gestational diabetes mellitus (21). However, at present this is the only study that describes itaconic acid as a potential serological biomarker for inflammation.…”

Development of a simple tool to predict the risk of postpartum diabetes in women with gestational diabetes mellitus

“…Unfortunately, our data did not contain metabolic or genetic measurements, which are useful for diabetes prediction in general [19][20][21][22]. However, with a C-index of 0.75 for diabetes development after five years, the prediction performance of our risk score was almost identical to that of the Korean study, where C-indices of 0.77 and 0.74 with and without genetic markers were observed, respectively.…”