Early pregnancy factor: Tissues involved in its production in the mouse

Morton, H. Craig; Rolfe, Barbara E.; McNeill, L.; Clarke, P. F.; Clarke, Frank M.; Clunie, G. J. A.

doi:10.1016/0165-0378(80)90044-3

Cited by 46 publications

(32 citation statements)

References 13 publications

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“…Previous studies have demonstrated that EPF-A is the moiety of the EPF complex which determines binding to lympho¬ cytes, presumably to a receptor Morton et al, 1980). The inhibitory effect of EPF-A when present in an unassociated form would then be explained by competition between EPF-A and EPF for binding to this receptor.…”

Section: Introductionmentioning

confidence: 99%

The appearance and characteristics of early pregnancy factor in the pig

Morton¹,

Morton²,

Ellendorff³

1983

Reproduction

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Summary. The occurrence of early pregnancy factor in the pig has been established by the rosette inhibition test and by the criteria that gel filtration of serum resulted in a number of peaks of activity similar to those observed in other species. In the pig EPF is present virtually to the end of pregnancy, with a biphasic production in which the titres of EPF decline markedly in mid-pregnancy. Free EPF-A appears concurrently with EPF in the first 3 weeks of pregnancy in some but not all pigs. The presence of excess EPF-A has an inhibitory effect in the rosette inhibition test and modifications, including an initial serum dialysis step, have been introduced into the test to take account of this inhibitory effect.

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Section: Introductionmentioning

confidence: 99%

The appearance and characteristics of early pregnancy factor in the pig

Morton¹,

Morton²,

Ellendorff³

1983

Reproduction

Self Cite

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“…It has been shown that EPF from serum 1 to 7 days after gestation is separated to EPF-A and EPF-B by 40% ammonium sulfate fractionation [4,9]. EPF-A (soluble in 40% ammonium sulfate) is produced by the oviduct during estrus and pregnancy, and EPF-B (insoluble in 40% ammonium sulfate) is produced by the ovary only during pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Isolation and Purification of Early Pregnancy Factor (EPF) in Rat Serum.

Ikemizu

Yamazaki

Takahashi

et al. 1996

Journal of Reproduction and Development

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“…Maternal ('early') EPF is produced during the pre-and peri-implantation periods while production offetal (,late') EPF begins in the peri-implantation stage and persists until at least mid-term. Maternal EPF consists of two components, EPF-A and EPF-B Morton et al 1980;Cavanagh et al 1982). EPF-A is oestrus-dependent and its presence in precursor form has been demonstrated in serum around the time of ovulation in mice , humans (B. E. Rolfe, personal communication), sheep (H. Morton, unpublished data) and pigs .…”

Section: Production Of Epfmentioning

confidence: 99%

“…Morton et al (1980) and Cavanagh et al (1982) have shown that medium from fertilized mouse ova cultured in vitro does not have any detectable EPF at least until ova develop to the blastocyst stage; from this stage the production of fetal EPF from the embryo commences. Nancarrowet al (1981) similarly showed that infusates prepared from fertilized mouse ova did not contain EPF activity.…”

Section: Production Of Epfmentioning

confidence: 99%

Early Pregnancy Factor (EPF): A Link between Fertilization and Immunomodulation

Morton¹

1984

Aust. Jnl. Of Bio. Sci.

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Early pregnancy factor (EPF) is a pregnancy-dependent, suppressor-releasing hormone, which can be differentiated from other known pregnancy-associated substances by its physiological, biochemical and immunological characteristics. To date studies have shown that the presence of EPF in serum at anytime except during pregnancy is pathological and is associated with tumors of germ cell origin.EPF can be detected in serum within hours of fertilization, thus providing for the first time a means of monitoring in vitro the continuing viability of a fertilized egg in vivo. EPF has been shown to be a link between fertilization and immunomodulation. Fertilization of the ovum initiates a chain of events which includes production of EPF. EPF then binds to lymphocytes; releasing soluble suppressor substances, which in turn modulate the mother's immune system. Thus it is proposed that the conceptus ensures its own defence against immunological rejection.

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Early pregnancy factor: Tissues involved in its production in the mouse

Cited by 46 publications

References 13 publications

The appearance and characteristics of early pregnancy factor in the pig

The appearance and characteristics of early pregnancy factor in the pig

Isolation and Purification of Early Pregnancy Factor (EPF) in Rat Serum.

Early Pregnancy Factor (EPF): A Link between Fertilization and Immunomodulation

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