Early pregnancy exposure to endocrine disrupting chemical mixtures are associated with inflammatory changes in maternal and neonatal circulation

Kelley, A. Taylor; Banker, Margaret; Goodrich, Jaclyn M.; Dolinoy, Dana C.; Burant, Charles F.; Domino, Steven E.; Smith, Yolanda R.; Song, Peter

doi:10.1038/s41598-019-41134-z

Cited by 95 publications

(52 citation statements)

References 96 publications

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“…The timing of the exposure to phthalates can be the source of discrepancies. Prenatal exposure to phthalates may induce more severe effects because pregnancy is a sensitive window for toxicant exposure as a result of fetal development [ 192 ]. According to Meltzer et al [ 138 ], the postnatal exposure to DEHP decreased the estradiol levels in female Sprague-Dawley rats.…”

Section: Hormonal Mechanisms Of Phthalates’ Action On Reproductivementioning

confidence: 99%

Effects and Mechanisms of Phthalates’ Action on Reproductive Processes and Reproductive Health: A Literature Review

Hlisníková

Petrovičová

Kolena

et al. 2020

IJERPH

151

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The production of plastic products, which requires phthalate plasticizers, has resulted in the problems for human health, especially that of reproductive health. Phthalate exposure can induce reproductive disorders at various regulatory levels. The aim of this review was to compile the evidence concerning the association between phthalates and reproductive diseases, phthalates-induced reproductive disorders, and their possible endocrine and intracellular mechanisms. Phthalates may induce alterations in puberty, the development of testicular dysgenesis syndrome, cancer, and fertility disorders in both males and females. At the hormonal level, phthalates can modify the release of hypothalamic, pituitary, and peripheral hormones. At the intracellular level, phthalates can interfere with nuclear receptors, membrane receptors, intracellular signaling pathways, and modulate gene expression associated with reproduction. To understand and to treat the adverse effects of phthalates on human health, it is essential to expand the current knowledge concerning their mechanism of action in the organism.

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Section: Hormonal Mechanisms Of Phthalates’ Action On Reproductivementioning

confidence: 99%

Effects and Mechanisms of Phthalates’ Action on Reproductive Processes and Reproductive Health: A Literature Review

Hlisníková

Petrovičová

Kolena

et al. 2020

IJERPH

151

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“…Associations between PBDE congeners and inflammation were described (although they did not reach statistical significance) in a representative USA sample from the National Health and Nutrition survey [65]. A significant association of first-trimester Interleukin (IL)-6 with environmental EDC exposure was described by Kelley et al [66]. Interestingly, in our experience, increased IL-6 is associated with reduced IGF bioavailability in the placenta and fetal growth restriction [67], thus leading to a possible further pathogenetic mechanism that might not be entirely due to hypoxia, as originally hypothesized [67][68][69].…”

Section: Pathogenetic Mechanismsmentioning

confidence: 99%

Endocrine-Disrupting Chemicals in Human Fetal Growth

Street

Bernasconi

2020

IJMS

111

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Fetal growth is regulated by a complex interaction of maternal, placental, and fetal factors. The effects and outcomes that chemicals, widely distributed in the environment, may have on the health status of both the mother and the fetus are not yet well defined. Mainly mixtures of chemical substances are found in the mothers and placenta. Exposure to endocrine-disrupting chemicals (EDCs) can be associated with fetal growth retardation, thyroid dysfunction, and neurological disorders. EDCs mostly interfere with insulin, glucocorticoid, estrogenic, and thyroid pathways, with subsequent effects on normal endocrine and metabolic functions, which cause changes in the epigenome and state of inflammation with life-long effects and consequences. International scientific societies recommend the implementation of research and of all possible preventive measures. This review briefly summarizes all these aspects.

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“…[42,87,108] effect in the reproductive apparatus of the developed adult or in future generations [68]. Gender issues have been brought into consideration in the EDC debate [69,70] but need further investigation considering their impacts in early pregnancy, fetal development and genital malformations both in humans [71,72] and in wildlife [73].…”

Section: Costs Of Living At the Interfacementioning

confidence: 99%

Helping to heal nature and ourselves through human-rights-based and gender-responsive One Health

Garnier

Savić

Boriani³

et al. 2020

One Health Outlook

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The health of our planet and humanity is threatened by biodiversity loss, disease and climate crises that are unprecedented in human history, driven by our insatiable consumption and unsustainable production patterns, particularly food systems. The One Health approach is a pathway to synergistically addressing outcomes in term of health and sustainability, but gender issues at the One Health and biodiversity nexus are largely ignored.By examining the roles and responsibilities of Indigenous and Local People, and especially women, in conserving natural resources, and the social costs of living at the Human-Animal-Environment interface under current conservation strategies, we show that women bear a disproportionate health, poverty and climate burden, despite having pivotal roles in conserving biodiversity. To mitigate risks of emerging infectious diseases, food insecurity and climate change impacts, a gender perspective has previously been proposed, but implementation lags behind. Endemic zoonotic diseases, human-wildlife conflict and environmental pollution lack gender-sensitive frameworks. We demonstrate that women can be powerful agents for change at all levels of society, from communities to businesses, and policy-making institutions, but gender inequalities still persist.We develop a framework for mainstreaming a gender-responsive and rights-based One Health approach, in order to heal ourselves and nature. Using a leverage-points perspective, we suggest a change of paradigm, from the pursuit of GDP and over-consumption, to a focus on human well-being and their reconnection with healthy environments, using a One Health understanding of nature and health. We recommend learning from Indigenous People to re-position ourselves within nature and to better conserve biodiversity. We also propose integration of gender equity in leadership, the respect of human rights, women’s rights (access to health care, healthy food, land tenure, natural resources, education, and economic opportunities), and the rights of nature, through the implementation of gender-responsive and rights-based One Health Action Plans, at policy-making level, in the private sector and the civil society. As the COVID-19 pandemic continues to unveil deep socio-economic inequities in the wealthiest economies and the vital role of nature in supporting our health, we argue to seize this opportunity to build back better and improve resilience and sustainability by using a gender-responsive and rights-based One Health approach.

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Early pregnancy exposure to endocrine disrupting chemical mixtures are associated with inflammatory changes in maternal and neonatal circulation

Cited by 95 publications

References 96 publications

Effects and Mechanisms of Phthalates’ Action on Reproductive Processes and Reproductive Health: A Literature Review

Effects and Mechanisms of Phthalates’ Action on Reproductive Processes and Reproductive Health: A Literature Review

Endocrine-Disrupting Chemicals in Human Fetal Growth

Helping to heal nature and ourselves through human-rights-based and gender-responsive One Health

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