Early predictors of neurodevelopment after perinatal arterial ischemic stroke: a systematic review and meta-analysis

Baak, Lisanne M; Aa, Niek E. van der; Verhagen, Annemijn A E; Dudink, Jeroen; Groenendaal, Floris; Nijboer, Cora H.; Benders, Manon J. N. L.; Wagenaar, Nienke

doi:10.1038/s41390-022-02433-w

Cited by 4 publications

(5 citation statements)

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“…A study that examined long-term outcomes of 232 children with PAIS up to 13 years after stroke diagnosis found that 40% of children had normal outcomes, 33% had mild deficits and 27% had moderate-severe deficits [46]. Arterial distribution of the stroke is an important consideration when predicting outcomes [48,49 ▪ ,50]. Middle cerebral artery stroke is the most commonly implicated arterial territory, and strokes in this region are associated with increased risk for motor impairment, cerebral palsy, cognitive impairment, visual field defects and epilepsy [48,49 ▪ ].…”

Section: Perinatal Arterial Ischemic Strokementioning

confidence: 99%

“…Arterial distribution of the stroke is an important consideration when predicting outcomes [48,49 ▪ ,50]. Middle cerebral artery stroke is the most commonly implicated arterial territory, and strokes in this region are associated with increased risk for motor impairment, cerebral palsy, cognitive impairment, visual field defects and epilepsy [48,49 ▪ ]. Posterior cerebral artery strokes have been associated with visual field defects and epilepsy [50].…”

Section: Perinatal Arterial Ischemic Strokementioning

confidence: 99%

“…Multifocal strokes can be seen secondary to placental emboli, and outcomes will depend on the size and location of the lesions. Motor impairment and cerebral palsy are associated with strokes involving the posterior limb of the internal capsule, cerebral peduncles or basal ganglia [49 ▪ ,51]. Mild cognitive impairment has been reported in children with a history of PAIS, with greater impairment seen in strokes involving the frontal lobe [49 ▪ ,52].…”

Section: Perinatal Arterial Ischemic Strokementioning

confidence: 99%

“…Motor impairment and cerebral palsy are associated with strokes involving the posterior limb of the internal capsule, cerebral peduncles or basal ganglia [49 ▪ ,51]. Mild cognitive impairment has been reported in children with a history of PAIS, with greater impairment seen in strokes involving the frontal lobe [49 ▪ ,52]. Stroke in the occipital lobe or the optic radiations are associated with visual disturbances and visual field defects [49 ▪ ].…”

Section: Perinatal Arterial Ischemic Strokementioning

confidence: 99%

“…Mild cognitive impairment has been reported in children with a history of PAIS, with greater impairment seen in strokes involving the frontal lobe [49 ▪ ,52]. Stroke in the occipital lobe or the optic radiations are associated with visual disturbances and visual field defects [49 ▪ ].…”

Section: Perinatal Arterial Ischemic Strokementioning

confidence: 99%

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Neuroimaging to guide neuroprognostication in the neonatal intensive care unit

Christensen,

de Vries,

Cizmeci

2023

Current Opinion in Pediatrics

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Purpose of review Neurological problems are common in infants admitted to the neonatal intensive care unit (NICU). Various neuroimaging modalities are available for neonatal brain imaging and are selected based on presenting problem, timing and patient stability. Recent findings Neuroimaging findings, taken together with clinical factors and serial neurological examination can be used to predict future neurodevelopmental outcomes. In this narrative review, we discuss neonatal neuroimaging modalities, and how these can be optimally utilized to assess infants in the NICU. We will review common patterns of brain injury and neurodevelopmental outcomes in hypoxic-ischemic encephalopathy, perinatal arterial ischemic stroke and preterm brain injury. Summary Timely and accurate neuroprognostication can identify infants at risk for neurodevelopmental impairment and allow for early intervention and targeted therapies to improve outcomes.

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Section: Perinatal Arterial Ischemic Strokementioning

confidence: 99%