Early Predictors of Acute Kidney Injury (AKI) in a Sample of Egyptian Full Term Neonates

El-Gamasy, Mohamed Abdelaziz

doi:10.21767/2471-299x.1000054

Cited by 2 publications

(2 citation statements)

References 26 publications

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“…Cystatin C increases abnormally in serum when GFR decreases to 88 ml/min/1.73 m² and can detect AKI 1 to 2 days prior to serum creatinine 5 . Up to date several studies suggested that cystatin C is a preferred and sensitive marker for early detection of acute kidney injury [6][7][8] .…”

Section: Introductionmentioning

confidence: 99%

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Diagnostic Validity of Serum Cystatin C for Detection of Acute Kidney Injury in Children

Luna

Sultana

Yusuf

et al. 2021

Bangladesh J. Infect. Dis.

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Background: Detection of acute kidney injury is very essential among the children. Objective: The purpose of the present study was to validate the serum cystatin C for the detection of acute kidney injury in children. Methodology: This cross-sectional study was conducted in the Department of Paediatric Nephrology with the collaboration of Paediatric Gastroenterology, Paediatric Neurology, Paediatric Neonatology and Microbiology and Immunology at Bangabandhu Sheikh Mujib University, Dhaka, Bangladesh from May 2018 to July 2019 for a period of one year. Patients with the age group of 1 month to 17 years, who were at risk of AKI, and admitted in the inpatient department of Pediatrics and allied at Bangabandhu Sheikh Mujib University, Dhaka, Bangladesh during this study period in both sexes were selected as study population. To detect AKI, serum creatinine was measured at 0 h (baseline), 48 h and 5th day respectively. Serum cystatin C were measured at 0 (baseline) and 48 h respectively for all patients. Result: A total number of 52 patients were enrolled in this study. Here the AUC was 0.93 with 95% CI (0.864 - 0.995). Serum cystatin C had sensitivity of 95% (95% CI 77.9%-099.7%) with specificity 84% (95% CI 73.7%-87.3%), PPV 79% (95% CI 64.9%-83.1%), NPV 96% (95% CI 84.2%-99.8%), accuracy 88.7% (95% CI 75.3%-92.1%), positive likelihood ratio 6.08 and negative likelihood ratio 0.06 (95% CI 2.96-7.87 and 0.003-0.300 respectively). Conclusion: In conclusion the diagnostic validity of serum cystatin C for the detection of AKI is very high among the children. Bangladesh Journal of Infectious Diseases 2020;7(2):44-48

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Section: Introductionmentioning

confidence: 99%

“…Early detection and intervention can prevent further progression of renal injury and hence decrease complication, morbidity and mortality 7 . There was no such study so far in this regard in Bangladesh.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic Validity of Serum Cystatin C for Detection of Acute Kidney Injury in Children

Luna

Sultana

Yusuf

et al. 2021

Bangladesh J. Infect. Dis.

View full text Add to dashboard Cite

show abstract

Plasma cystatin C versus renal resistive index as early predictors of acute kidney injury in critically ill neonates

Elsadek

El-Gamasy

Behiry

et al. 2020

Journal of Pediatric Urology

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Early Predictors of Acute Kidney Injury (AKI) in a Sample of Egyptian Full Term Neonates

Abstract: Background: AKI is an independent predictor of morbidity and mortality for critically ill neonates at Neonatal Intensive Care Unit (NICU). Cystatin-C and beta 2 microglobulin are two promising early biomarkers for AKI.

Cited by 2 publications

References 26 publications

Diagnostic Validity of Serum Cystatin C for Detection of Acute Kidney Injury in Children

Diagnostic Validity of Serum Cystatin C for Detection of Acute Kidney Injury in Children

Plasma cystatin C versus renal resistive index as early predictors of acute kidney injury in critically ill neonates

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