Early Prediction of Skin Viability Using Visible Diffuse Reflectance Spectroscopy and Autofluorescence Spectroscopy

Zhu, Caigang; Chen, Shuo; Chui, Christopher Hoe-Kong; Tan, Bien‐Keem; Liu, Quan

doi:10.1097/prs.0000000000000399

Cited by 16 publications

(10 citation statements)

References 24 publications

(23 reference statements)

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“…From Table 1 to and Figure , it can be found that the autofluorescence imaging always yields better performance compared to diffuse reflectance imaging. The better performance of autofluorescence imaging compared with diffuse reflectance imaging in the classification between the control group and the occluded group in Table agrees with our earlier flap viability study [22], likely because autofluorescence measurements offers an advantage for detecting tissue ischemia . In contrast, the worse performance of diffuse reflectance imaging in Table 1 to and Figure disagrees with the results in our parallel point measurement study .…”

Section: Discussionsupporting

confidence: 63%

Spectral diffuse reflectance and autofluorescence imaging can perform early prediction of blood vessel occlusion in skin flaps

Chen

Zhu

Chui

et al. 2016

Journal of Biophotonics

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Flap transfer has become a common technique in reconstructive surgery. However, a significant number of compromised skin flaps are not successfully salvaged because the current clinical method for flap assessment relies heavily on the clinician's experience. Vascular occlusion is the major reason for flap failure, thus the accurate and objective early prediction of blood vessel occlusion is vitally important. Our parallel point measurement study has demonstrated the great potential of joint diffuse reflectance and autofluorescence spectroscopy in the early detection and differentiation of venous and arterial occlusion in skin flaps. Unfortunately, the technique of point measurements is not suitable to examine a large skin flap when a high spatial resolution is required. In this study, we attempted to overcome this problem by performing spectral diffuse reflectance and autofluorescence imaging on a rat skin flap model. Both imaging data and reconstructed spectra were used to statistically differentiate control flaps, arterially occluded flaps and venously occluded flaps. Our preliminary results suggest that the technique of joint diffuse reflectance and autofluorescence spectroscopic imaging can achieve high classification accuracy thus could be used to detect and differentiate flaps with venous and arterial occlusion accurately at an early time point in a large skin flap. Typical reconstructed spectra of (a) diffuse reflectance and (b) autofluorescence after normalization.

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Section: Discussionsupporting

confidence: 63%

Spectral diffuse reflectance and autofluorescence imaging can perform early prediction of blood vessel occlusion in skin flaps

Chen

Zhu

Chui

et al. 2016

Journal of Biophotonics

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“…Fluorescence spectroscopy utilizing exogenous [12] and endogenous fluorophores [13][14][15][16] to measure the metabolic rate of tissue has been reported in recent years, which could compensate for the weakness of those methods measuring the peripheral information of flap perfusion. Previously we evaluated both visible diffuse reflectance and auto-fluorescence spectroscopy to identify their values for the early prediction of skin flap viability in a MacFarlane rat dorsal skin flap model [17], our results show that either visible diffuse reflectance spectroscopy or autofluorescence spectroscopy alone can predict skin viability accurately and the combination of the two yields the highest accuracy for early prediction in the first 15 minutes.…”

Section: Introductionmentioning

confidence: 89%

Early detection and differentiation of venous and arterial occlusion in skin flaps using visible diffuse reflectance spectroscopy and autofluorescence spectroscopy

Zhu

Chen

Chui

et al. 2016

Biomed. Opt. Express

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Our previous preclinical study demonstrated that both visible diffuse reflectance and autofluorescence spectroscopy, each of which yields a different set of physiological information, can predict skin flap viability with high accuracy in a MacFarlane rat dorsal skin flap model. In this report, we further evaluated our technique for the early detection and differentiation of venous occlusion and arterial occlusion in a rat groin flap model. We performed both diffuse reflectance and autofluorescence measurements on the skin flap model and statistically differentiated between flaps with and without occlusions as well as between flaps with venous occlusion and those with arterial occlusion based on these non-invasive optical measurements. Our preliminary results suggested that visible diffuse reflectance and autofluorescence spectroscopy can be potentially used clinically to detect both venous and arterial occlusion and differentiate one from the other accurately at an early time point.

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“…Our works are focused on the combination of steady-state and spatially resolved Diffuse Reflectance (DR) spectroscopy and multiple excitation AutoFluorescence (AF) spectroscopy to improve diagnosis efficiency of skin precancerous tissues 1,10,11 . For simplicity and cost effective instrumentation considerations, steadystate excitation and spatial resolution are preferred 16 .…”

Section: Introductionmentioning

confidence: 99%

Multidimensional spectroscopic data fusion improves precancerous tissue discrimination based on spatially resolved autofluorescence and diffuse reflectance spectroscopy

et al. 2015

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Early Prediction of Skin Viability Using Visible Diffuse Reflectance Spectroscopy and Autofluorescence Spectroscopy

Abstract: These findings will be helpful to clinicians for making a precise judgment on flap viability. Furthermore, the authors' results highlight the advantage of using autofluorescence spectroscopy in the early prediction of skin flap viability relative to diffuse reflectance spectroscopy.

Cited by 16 publications

References 24 publications

Spectral diffuse reflectance and autofluorescence imaging can perform early prediction of blood vessel occlusion in skin flaps

Spectral diffuse reflectance and autofluorescence imaging can perform early prediction of blood vessel occlusion in skin flaps

Early detection and differentiation of venous and arterial occlusion in skin flaps using visible diffuse reflectance spectroscopy and autofluorescence spectroscopy

Multidimensional spectroscopic data fusion improves precancerous tissue discrimination based on spatially resolved autofluorescence and diffuse reflectance spectroscopy

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