Early prediction of drug metabolism and toxicity: systems biology approach and modeling

Bugrim, Andrej; Nikolskaya, Tatiana; Nikolsky, Yuri

doi:10.1016/s1359-6446(03)02971-4

Cited by 170 publications

(120 citation statements)

References 52 publications

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“…We selected differentially expressed genes having a q-value < 10% for the Pathway analysis, which was performed using MetaCore™ pathway analysis software [15].…”

Section: Microarray Data Analysismentioning

confidence: 99%

Analysis of White Adipose Tissue Gene Expression Reveals CREB1 Pathway Altered in Huntington’s Disease

McCourt

Parker²,

Silajdžić

et al. 2015

JHD

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“…We selected differentially expressed genes having a q-value < 10% for the Pathway analysis, which was performed using MetaCore™ pathway analysis software [15].…”

Section: Microarray Data Analysismentioning

confidence: 99%

Analysis of White Adipose Tissue Gene Expression Reveals CREB1 Pathway Altered in Huntington’s Disease

McCourt

Parker²,

Silajdžić

et al. 2015

JHD

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“…They make use of mathematical models to assess drug absorption, distribution, metabolism and excretion (Pieper & Bertau, 2010). The most commonly used models are the physiologically-based pharmacokinetics (Leahy, 2003), the systems biology-based drug metabolism simulation (Bugrim et al, 2004), the quantitative structure-activity relationship modelling (Chang & Swaan, 2006), and the computational oral absorption simulation (Sugano, 2009). More specific information on the topic has been recently reviewed by Bertau et al (2008) and Pieper & Bertau (2010).…”

Section: Fig 2 Scheme Of the Simulator Of The Human Intestinal Micrmentioning

confidence: 99%

The Gut Microbiota as Target for Innovative Drug Development: Perspectives and a Case Study of Inflammatory Bowel Diseases

Vermeiren¹,

Possemiers²,

Marzorati³

et al. 2011

Drug Development - A Case Study Based Insight Into Modern Strategies

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“…As Jay Bailey states (Gibbs, 2001), ''one reason why drug discovery technologies have not paid off as hoped is that they are based on the naive idea that you can redirect the cell in a way that you want it go by sending in a drug that inhibits only one protein,'' Systems Biology provides a novel and revolutionary perspective on health, disease, and the way to pharmaceutical discovery . Many of the current problems of unanticipated toxicity of drugs that has been plaguing the pharmaceutical industry recently is a result of missing out on a systems level perspective (Bugrim et al, 2004;Ekins et al, 2005).…”

Section: Systems Biology Toolsmentioning

confidence: 99%

Systems Biology: The synergistic interplay between biology and mathematics

Dhurjati

Mahadevan

2008

Can J Chem Eng

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Systems Biology is a nascent field that arose from the technology driven omics measurement revolution. It goes beyond mere data analysis and focuses on the biological behaviour emerging from the dynamic interactions between system components that are organized in a hierarchical and highly connected manner. Mathematical models have been used as a conceptual framework to study such systems and their impact is maximal when there is a synergistic interplay of the models with experimental data and biological domain knowledge. The review provides an introduction to the modelling process and selectively highlights manuscripts that have strong biological impact.La biologie des systèmes est un domaine qui est apparu récemment avec la révolution dans les mesures omiques dues aux progrès technologiques. Ce domaine va au-delà de la simple analyse et s'intéresse au comportement biologique venant des interactions dynamiques entre les composantes de systèmes qui sont organisées de façon hiérarchique et hautement interreliées. Des modèles mathématiques ontété utilisés comme cadre conceptuel afin d'étudier ces systèmes, et leur impact est maximal lorsqu'il y a une interrelation synergétique entre d'une part, les modèles, et d'autre part, les données expérimentales et les connaissances dans le domaine biologique. Cette revue de la littérature fournit une introduction aux articles mettant en lumière les procédés de modélisation et la sélectivité et qui ont un fort impact biologique.

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Early prediction of drug metabolism and toxicity: systems biology approach and modeling

Cited by 170 publications

References 52 publications

Analysis of White Adipose Tissue Gene Expression Reveals CREB1 Pathway Altered in Huntington’s Disease

Analysis of White Adipose Tissue Gene Expression Reveals CREB1 Pathway Altered in Huntington’s Disease

The Gut Microbiota as Target for Innovative Drug Development: Perspectives and a Case Study of Inflammatory Bowel Diseases

Systems Biology: The synergistic interplay between biology and mathematics

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