2004
DOI: 10.1016/s1359-6446(03)02971-4
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Early prediction of drug metabolism and toxicity: systems biology approach and modeling

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Cited by 169 publications
(120 citation statements)
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“…We selected differentially expressed genes having a q-value < 10% for the Pathway analysis, which was performed using MetaCore™ pathway analysis software [15].…”
Section: Microarray Data Analysismentioning
confidence: 99%
“…We selected differentially expressed genes having a q-value < 10% for the Pathway analysis, which was performed using MetaCore™ pathway analysis software [15].…”
Section: Microarray Data Analysismentioning
confidence: 99%
“…They make use of mathematical models to assess drug absorption, distribution, metabolism and excretion (Pieper & Bertau, 2010). The most commonly used models are the physiologically-based pharmacokinetics (Leahy, 2003), the systems biology-based drug metabolism simulation (Bugrim et al, 2004), the quantitative structure-activity relationship modelling (Chang & Swaan, 2006), and the computational oral absorption simulation (Sugano, 2009). More specific information on the topic has been recently reviewed by Bertau et al (2008) and Pieper & Bertau (2010).…”
Section: Fig 2 Scheme Of the Simulator Of The Human Intestinal Micrmentioning
confidence: 99%
“…As Jay Bailey states (Gibbs, 2001), ''one reason why drug discovery technologies have not paid off as hoped is that they are based on the naive idea that you can redirect the cell in a way that you want it go by sending in a drug that inhibits only one protein,'' Systems Biology provides a novel and revolutionary perspective on health, disease, and the way to pharmaceutical discovery . Many of the current problems of unanticipated toxicity of drugs that has been plaguing the pharmaceutical industry recently is a result of missing out on a systems level perspective (Bugrim et al, 2004;Ekins et al, 2005).…”
Section: Systems Biology Toolsmentioning
confidence: 99%