Early Postoperative Oral Feeding in Gastresophageal Tumors Surgery: A Randomized Controlled Trial

Shoar, Saeed; Mahmoodzadeh, Hashem; Araghi, Negin Hosseini; Mahboobi, Nima; Sirati, Fereidoon; Khorgami, Zhamak

doi:10.1016/j.jss.2012.10.921

Cited by 3 publications

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“…Although these findings are promising, the patient group was very heterogeneous and included only a few patients undergoing an oesophagectomy. There is one other randomised controlled trial, of which the definitive results are still awaited, that among others included patients undergoing oesophagectomy 12. Next to these studies, one conference abstract has been published in 2008 on a small prospective study in which patients undergoing oesophagectomy with three-field lymph node dissection started an oral liquid diet on day 2 postoperative 13.…”

Section: Discussionmentioning

confidence: 99%

“…There is one other randomised controlled trial, of which the definitive results are still awaited, that among others included patients undergoing oesophagectomy. 12 Next to these studies, one conference abstract has been published in 2008 on a small prospective study in which patients undergoing oesophagectomy with three-field lymph node dissection started an oral liquid diet on day 2 postoperative. 13 Altogether, this illustrates that data on early oral intake are still scarce and more research is needed.…”

Section: Discussionmentioning

confidence: 99%

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Study protocol for the nutritional route in oesophageal resection trial: a single-arm feasibility trial (NUTRIENT trial)

et al. 2014

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IntroductionThe best route of feeding for patients undergoing an oesophagectomy is unclear. Concerns exist that early oral intake would increase the incidence and severity of pneumonia and anastomotic leakage. However, in studies including patients after many other types of gastrointestinal surgery and in animal experiments, early oral intake has been shown to be beneficial and enhance recovery. Therefore, we aim to determine the feasibility of early oral intake after oesophagectomy.Methods and analysisThis study is a feasibility trial in which 50 consecutive patients will start oral intake directly following oesophagectomy. Primary outcomes will be the frequency and severity of anastomotic leakage and (aspiration) pneumonia. Clinical parameters will be registered prospectively and nutritional requirements and intake will be assessed by a dietician. Surgical complications will be registered.Ethics and disseminationApproval for this study has been obtained from the Medical Ethical Committee of the Catharina Hospital Eindhoven and the study has been registered at the Dutch Trial Register, NTR4136. Results will be published and presented at international congresses.DiscussionWe hypothesise that the oral route of feeding is safe and feasible following oesophagectomy, as has been shown previously for other types of gastrointestinal surgery. It is expected that early oral nutrition will result in enhanced recovery. Furthermore, complications related to artificial feeding, such as jejunostomy tube feeding, are believed to be reduced. However, (aspiration) pneumonia and anastomotic leakage are potential risks that are carefully monitored.Trial registration numberNTR4136.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%