Early-postoperative magnetic resonance imaging in glial tumors: prediction of tumor regrowth and recurrence

Ekinci, Gazanfer; Akpınar, İhsan; Baltacıoğlu, Feyyaz; Erzen, Canan; Kılıç, Türker; Elmacı, İlhan; Pamir, Necmettin

doi:10.1016/s0720-048x(02)00027-x

Cited by 74 publications

(60 citation statements)

References 26 publications

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“…Any contrast-enhanced area on T 1 -weighted images was considered to be residual tumor. 8) In the analyzed cohort, the resection rate was 100% in 22 patients, and between 95% and 99% in the other 21 patients.…”

Section: Methodsmentioning

confidence: 86%

“…Nevertheless, the criteria for total removal were rather strict, since any contrast-enhanced area on postoperative MR imaging obtained within 3 days after surgery was considered to be residual neoplasm. 8) In fact, visual side-by-side comparison of MR images still represents a rather common method for the evaluation of treated intracranial tumors, but is less accurate compared to more sophisticated tools. 9) According to recent recommendations of the Response Assessment in Neuro-Oncology Working Y. Konishi et al…”

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confidence: 99%

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Patterns of Intracranial Glioblastoma Recurrence After Aggressive Surgical Resection and Adjuvant Management: Retrospective Analysis of 43 Cases

Konishi

Muragakı

Iseki

et al. 2012

Neurol. Med. Chir.(Tokyo)

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The present retrospective study evaluated the recurrence patterns after aggressive surgical removal of intracranial glioblastomas in 43 consecutive adult patients. The resection rate of the enhanced lesion on magnetic resonance imaging was 100% and 95-99% in 22 and 21 cases, respectively. All patients received postoperative fractionated radiotherapy (60 Gy in 30 fractions) with additional chemotherapy (25 cases) or vaccine therapy (18 cases). During follow-up (median 17 months), tumor recurrence was identified in 33 patients, most frequently regional within the wall of the resection cavity (20 cases). No clinical factor differed significantly between the groups of patients with regional or marginal tumor progression (N ＝ 22) and patients with distant or multiple recurrences (N ＝ 8). Progression-free survival did not differ significantly between these two groups (p ＝ 0.27). However, overall survival was significantly longer (p ＝ 0.04) in patients with regional or marginal tumor progression, and constituted 90% and 54% at 1 and 2 years after surgery, respectively, compared to 75% and 0% in patients with distant or multiple recurrences. Aggressive surgical resection and adjuvant management of intracranial glioblastoma may change its recurrence pattern. Tumor progression appears in the wall of the resection cavity or within 2 cm from its margin in approximately half of patients.

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Section: Methodsmentioning

confidence: 86%

mentioning

confidence: 99%

Patterns of Intracranial Glioblastoma Recurrence After Aggressive Surgical Resection and Adjuvant Management: Retrospective Analysis of 43 Cases

Konishi

Muragakı

Iseki

et al. 2012

Neurol. Med. Chir.(Tokyo)

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“…2,9,10,30 The resection of an enhancing tumor (grosstotal resection) is known to prolong progression-free and overall survival time of patients. 32,35,36 Most tumor progressions are detected within the 1st year after surgery; thus, accurate postoperative assessment is important.…”

Section: ©Aans 2014mentioning

confidence: 99%

“…5,21,23 In the past, the extent of surgical tumor removal was estimated by the neurosurgeons. 2,10,26 By allowing a comparison with the preoperative MRI findings, postoperative MRI, in recent years, has become the method of choice for determining the presence of any residual tumor. 10 Early postoperative MRI (within 72 hours) is commonly used to determine if a complete tumor resection has been achieved or to show how much enhancing tumor remains in situ.…”

Section: ©Aans 2014mentioning

confidence: 99%

“…2,10,26 By allowing a comparison with the preoperative MRI findings, postoperative MRI, in recent years, has become the method of choice for determining the presence of any residual tumor. 10 Early postoperative MRI (within 72 hours) is commonly used to determine if a complete tumor resection has been achieved or to show how much enhancing tumor remains in situ. 2 This postoperative MRI study is the basis for making postsurgical decisions and monitoring the effects of subsequent adjuvant therapy.…”

confidence: 99%

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Time window for postoperative reactive enhancement after resection of brain tumors: less than 72 hours

Lescher

Schniewindt

Jurcoane

et al. 2014

FOC

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Object Early postoperative MRI within 72 hours after brain tumor surgery is commonly used to assess residual contrast-enhancing tumor. The 72-hour window is commonly accepted because previous 1.5-T MRI studies have not found confounding postoperative reactive contrast enhancement in this time frame. The sensitivity to detect contrast enhancement increases with the field strengths. Therefore, the authors aimed to assess whether the 72-hour window is also appropriate for the MRI scanner with a field strength of 3 T. Methods The authors retrospectively analyzed findings on early postsurgical MR images acquired in 46 patients treated for high-grade gliomas. They performed 3-T MRI within 7 days before surgery and within 72 hours thereafter. The appearance of enhancement was categorized as postoperative reactive enhancement or tumoral enhancement by comparison with the pattern and location of presurgical enhancing tumor. Results Postoperative reactive enhancement was present in 15 patients (32.6%). This enhancement, not seen on presurgical MRI, had a marginal or leptomeningeal/dural pattern. In 13 patients (28.3%) postsurgical enhancement was found within the first 72 postoperative hours, with the earliest seen 22:57 hours after surgery. Subsequent MR scans in patients with postoperative reactive enhancement did not reveal tumor recurrence in these regions. Conclusions Postoperative reactive enhancement earlier than 72 hours after brain tumor surgery can be expected in about one-third of the cases in which a 3-T scanner is used. This might be due to the higher enhancement-to-brain contrast at higher field strengths. Therefore, the time window of 72 hours does not prevent reactive enhancement, which, however, can be recognized as such comparing it with presurgical enhancing tumor.

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Central Nervous System and Peripheral Nerves

Ormond

Bouras

Moore

et al. 2018

The American Cancer Society's Oncology in Practice

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Early-postoperative magnetic resonance imaging in glial tumors: prediction of tumor regrowth and recurrence

Cited by 74 publications

References 26 publications

Patterns of Intracranial Glioblastoma Recurrence After Aggressive Surgical Resection and Adjuvant Management: Retrospective Analysis of 43 Cases

Patterns of Intracranial Glioblastoma Recurrence After Aggressive Surgical Resection and Adjuvant Management: Retrospective Analysis of 43 Cases

Time window for postoperative reactive enhancement after resection of brain tumors: less than 72 hours

Central Nervous System and Peripheral Nerves

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