Early postnatal life as a critical time window for determination of long-term metabolic health

Plagemann, Andreas; Harder, Thomas; Schellong, Karen; Schulz, Sandra; Stupin, Jens H.

doi:10.1016/j.beem.2012.03.008

Cited by 90 publications

(63 citation statements)

References 59 publications

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Section: Introductionmentioning

confidence: 99%

“…This phenomenon, termed perinatal programming, in which intrauterine events are associated with later adverse changes, has attracted much attention (1-3). Substantial epidemiologic data have also suggested that the offspring whose mothers were diabetic during pregnancy are susceptible to metabolic disturbances induced by postnatal overnutrition, as seen with high-fat diet (HFD) or with increased caloric intake in early life (1)(2)(3)(4).Women who have diabetes during pregnancy and/or are obese and hyperinsulinemic are at risk of delivering macrosomic newborns (high birth weight), and both shortand long-term outcomes of macrosomic neonates are influenced by postnatal overnutrition (1-4). In high-birth-weight neonates, subsequent growth in infancy and risk of becoming obese or diabetic are directly and linearly linked-e.g., the higher the birth weight, the greater the risk of overweight and metabolic disturbances later in life (1-4).…”

mentioning

confidence: 99%

“…Women who have diabetes during pregnancy and/or are obese and hyperinsulinemic are at risk of delivering macrosomic newborns (high birth weight), and both shortand long-term outcomes of macrosomic neonates are influenced by postnatal overnutrition (1)(2)(3)(4). In high-birth-weight neonates, subsequent growth in infancy and risk of becoming obese or diabetic are directly and linearly linked-e.g., the higher the birth weight, the greater the risk of overweight and metabolic disturbances later in life (1)(2)(3)(4).…”

mentioning

confidence: 99%

“…In high-birth-weight neonates, subsequent growth in infancy and risk of becoming obese or diabetic are directly and linearly linked-e.g., the higher the birth weight, the greater the risk of overweight and metabolic disturbances later in life (1)(2)(3)(4). In contrast, pregnant women with severe, uncontrolled diabetes or diabetic complications, such as diabetic nephropathy and/or retinopathy, are at high risk of having a microsomic fetus (i.e., a fetus with intrauterine growth restriction (IUGR)) (5,6).…”

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confidence: 99%

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Post-weaning high-fat diet accelerates kidney injury, but not hypertension programmed by maternal diabetes

et al. 2015

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Background:The aim of this study was to establish the underlying mechanisms by which a post-weaning high-fat diet (HFD) accelerates the perinatal programming of kidney injury occurring in the offspring of diabetic mothers. Methods: Male mice, offspring of nondiabetic and diabetic dams were fed with normal diet (ND) or HFD from 4 to 20 wk of age. Rat renal proximal tubular cells were used in vitro. results: On ND, the offspring of dams with severe maternal diabetes had an intrauterine growth restriction (IUGR) phenotype and developed mild hypertension and evidence of kidney injury in adulthood. Exposing the IUGR offspring to HFD resulted in rapid weight gain, catch-up growth, and later to profound kidney injury with activation of renal TGFβ1 and collagen type IV expression, increased oxidative stress, and enhanced renal lipid deposition, but not systemic hypertension. Given our data, we speculate that HFD or free fatty acids may accelerate the process of perinatal programming of kidney injury, via increased CD36 and fatty acid-binding protein 4 expression, which may target reactive oxygen species, nuclear factor-kappa B, and TGFβ1 signaling in vivo and in vitro. conclusion: Early postnatal exposure to overnutrition with a HFD increases the risk of development of kidney injury, but not hypertension, in IUGR offspring of dams with maternal diabetes.d iabetes during pregnancy, whether gestational or pregestational diabetes (type 1 or type 2), results in offspring at high risk of developing hypertension, cardiovascular disease, and chronic kidney disease in adult life. This phenomenon, termed perinatal programming, in which intrauterine events are associated with later adverse changes, has attracted much attention (1-3). Substantial epidemiologic data have also suggested that the offspring whose mothers were diabetic during pregnancy are susceptible to metabolic disturbances induced by postnatal overnutrition, as seen with high-fat diet (HFD) or with increased caloric intake in early life (1)(2)(3)(4).Women who have diabetes during pregnancy and/or are obese and hyperinsulinemic are at risk of delivering macrosomic newborns (high birth weight), and both shortand long-term outcomes of macrosomic neonates are influenced by postnatal overnutrition (1-4). In high-birth-weight neonates, subsequent growth in infancy and risk of becoming obese or diabetic are directly and linearly linked-e.g., the higher the birth weight, the greater the risk of overweight and metabolic disturbances later in life (1-4). In contrast, pregnant women with severe, uncontrolled diabetes or diabetic complications, such as diabetic nephropathy and/or retinopathy, are at high risk of having a microsomic fetus (i.e., a fetus with intrauterine growth restriction (IUGR)) (5,6). Such infants may be markedly small for dates; but many develop excessive weight gain and increased fat deposition in early infancy, a proxy for neonatal overnutrition (7,8). However, the long-term outcome of IUGR offspring who experience overnutrition in early life is incomplet...

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Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Post-weaning high-fat diet accelerates kidney injury, but not hypertension programmed by maternal diabetes

et al. 2015

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“…However, it is an issue still open because some authors have found no association between low birth weight and obesity (7). In fact, there are no systematic reports showing an inverse association between birth weight and subsequent risk of obesity (8). Most studies in this area have focused on obesity itself.…”

mentioning

confidence: 99%

Early and Long-term Undernutrition in Female Rats Exacerbates the Metabolic Risk Associated with Nutritional Rehabilitation

Lizárraga-Mollinedo

Fernández-Millán

Frutos

et al. 2015

Journal of Biological Chemistry

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Background: Obesogenic effects of diets provided after undernutrition are controversial. Results: Undernourished rats transferred to high-lipid diets show hyperphagia, dyslipidemia, ectopic lipids, adipose inflammation, and signs of browning. Conclusion: Chronic food restriction increases metabolic risks of subsequent nutritional recovery, without inducing obesity. Significance: The present study may help to understand some deleterious consequences undergone by undernourished people submitted to nutritional rehabilitation.

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Reverting to a Healthy Diet during Lactation Normalizes Maternal Milk Lipid Content of Diet‐Induced Obese Rats and Prevents Early Alterations in the Plasma Lipidome of the Offspring

Castillo

Kuda

Kopecký

et al. 2022

Molecular Nutrition Food Res

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This study aims to assess in rats whether normalizing maternal diet during lactation prevents the harmful effects of western diet (WD) consumption during the whole perinatal period on the lipidomic profile in maternal milk and offspring plasma. Methods and Results: Control dams (CON-dams), fed with standard diet (SD); WD-dams, fed with WD prior and during gestation and lactation; and reversion dams (REV-dams), fed as WD-dams but moved to SD during lactation are followed. Lipidomic analysis is performed in milk and plasma samples from pups. Milk of WD-dams presents a different triacylglycerol composition and free fatty acid (FA) profile compared to CON-dams, including an increased ratio of pro-inflammatory to anti-inflammatory long-chain polyunsaturated FA. Such alterations, which are also present in the plasma of their offspring, are widely reversed in the milk of REV-dams and the plasma of their pups. This is related with the recovery of control adiponectin expression levels in the mammary gland, and the presence of decreased expression of pro-inflammatory factors. Conclusion: Implementing a healthy diet during lactation prevents early alterations in the plasma lipidome of pups associated to the maternal intake of an obesogenic diet, which may be related to the normalization of milk lipid content and the inflammatory state in the mammary gland.

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Early postnatal life as a critical time window for determination of long-term metabolic health

Cited by 90 publications

References 59 publications

Post-weaning high-fat diet accelerates kidney injury, but not hypertension programmed by maternal diabetes

Post-weaning high-fat diet accelerates kidney injury, but not hypertension programmed by maternal diabetes

Early and Long-term Undernutrition in Female Rats Exacerbates the Metabolic Risk Associated with Nutritional Rehabilitation

Reverting to a Healthy Diet during Lactation Normalizes Maternal Milk Lipid Content of Diet‐Induced Obese Rats and Prevents Early Alterations in the Plasma Lipidome of the Offspring

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