Early postnatal l-Dopa treatment causes behavioral alterations in female vs. male young adult Swiss mice

Matos, Lorena Oliveira de; Reis, Ana Luiza de Araujo Lima; Guerra, Lorena Terene Lopes; Guarnieri, Leonardo de Oliveira; Moraes, Muiara Aparecida; Arabe, Laila Blanc; Souza, Renan Pedra de; Pereira, Grace Schenatto; Souza, Bruno R.

doi:10.1016/j.neuropharm.2020.108047

Cited by 5 publications

(4 citation statements)

References 126 publications

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“…Our group's previous work showed that early life transient increase of dopamine leads to different behavior outcomes at early adolescence and adulthood in mice. Interestingly, we evideniated a shift response at different ages (Matos et al, 2018(Matos et al, , 2020. In accordance, other researches regarding the DAergic system describe different responses through ages (Brenhouse & Andersen, 2008;Corongiu et al, 2019;Nemoda et al, 2011;Zbukvic et al, 2017).…”

Section: Discussionsupporting

confidence: 90%

“…Alterations in the dopaminergic system are related to parallel changes in locomotor activity (Dunnett, 2005). In our previous work, we showed that increasing dopamine levels during the first days of life affect the locomotor activity of pubertal and adult female mice (de Matos et al, 2020;. In this study, we investigate if an acute injection of L-Dopa or dopamine receptor D1 and D2 agonists during the prepubertal period can change motor behavior.…”

Section: Related Locomotor Changesmentioning

confidence: 93%

“…Furthermore, early life disruptions alter DAergic function differently in males and females (Dwyer & Leslie, 2016;Kawakami et al, 2013;Stewart et al, 1991). A transient postnatal increase of DA leads to different behavior changes in male and female pubertal and adult mice (de Matos et al, 2018(de Matos et al, , 2020. Thus, adding female subjects to studies on puberty/adolescent time-window is relevant to understand better the differences seen in some psychopathologies.…”

Section: Introductionmentioning

confidence: 99%

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Effects of L-Dopa, SKF-38393, and quinpirole on exploratory, anxiety- and depressive-like behaviors in pubertal female and male mice

Moraes,

Árabe,

Resende

et al. 2024

Behavioural Brain Research

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Section: Discussionsupporting

confidence: 90%

Section: Related Locomotor Changesmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

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Effects of L-Dopa, SKF-38393, and quinpirole on exploratory, anxiety- and depressive-like behaviors in pubertal female and male mice

Moraes,

Árabe,

Resende

et al. 2024

Behavioural Brain Research

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“…Alterations in the dopaminergic system are related to parallel changes in locomotor activity (Dunnett, 2005). In our previous work, we showed that increasing dopamine levels during the first days of life affect the locomotor activity of pubertal and adult female mice (de Matos et al, 2020; 2018). In this study, we investigate if an acute injection of L-Dopa or dopamine receptor D1 and D2 agonists during the prepubertal period can change motor behavior.…”

Section: Resultsmentioning

confidence: 99%

Effects of L-Dopa, SKF-38393 and Quinpirole on exploratory, anxiety- and depressive-like behaviors in pubertal female and male mice

et al. 2021

Preprint

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Adolescence is a phase of substantial changes in the brain, characterized by maturational remodeling of many systems. This remodeling allows functional plasticity to adapt in a changing environment but turns this period into a neurodevelopmental vulnerable window. The dopaminergic system is under morphological and physiological changes during this phase. The disruption of its balance can lead to molecular variation and abnormal behavior - representing a risk factor for neuropsychiatric disorders. In the present study, we investigated if changes in the dopaminergic tone alter mice behavior in a receptor and sex-specific manner, specifically in the beginning of puberty period. We administered L-Dopa, SKF-38393 (D1 dopamine receptor agonist) and Quinpirole (D2 dopamine receptor agonist) and tested male and female mice motor, anxiety- and depressive-like behavior. While females displayed an impaired exploratory drive, males presented an intense depressive-like response. Our results provide insights into the function of dopaminergic development in adolescent behavior and highlight the importance of studies in this time window with male and female subjects.

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Darpp-32 is regulated by dopamine and is required for the formation of GABAergic neurons in the developing telencephalon

Souza,

Codo,

Romano-Silva

et al. 2024

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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Early postnatal l-Dopa treatment causes behavioral alterations in female vs. male young adult Swiss mice

Cited by 5 publications

References 126 publications

Effects of L-Dopa, SKF-38393, and quinpirole on exploratory, anxiety- and depressive-like behaviors in pubertal female and male mice

Effects of L-Dopa, SKF-38393, and quinpirole on exploratory, anxiety- and depressive-like behaviors in pubertal female and male mice

Effects of L-Dopa, SKF-38393 and Quinpirole on exploratory, anxiety- and depressive-like behaviors in pubertal female and male mice

Darpp-32 is regulated by dopamine and is required for the formation of GABAergic neurons in the developing telencephalon

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