“…Hence different phenotypes can originate from the same genotype due to environmental stimuli via mechanisms such as epigenetic modifications [3]. For example, it has been proposed that intrauterine undernutrition can cause changes in endocrine response, body size, and composition as the fetus adapts to encounter the threat to survival [4,5]. Low birth weight and subsequent catch-up growth have both been associated with increased risk for later-life overweight [6,7] and higher susceptibility to related diseases such as cardiovascular disease [8] and diabetes [9].…”
Background/Aims: Fetal metabolism may be changed by the exposure to maternal factors, and the route to obesity may already set in utero. Cord blood metabolites might predict growth patterns and later obesity. We aimed to characterize associations of cord blood with birth weight, postnatal weight gain, and BMI in adolescence. Methods: Over 700 cord blood samples were collected from infants participating in the German birth cohort study LISAplus. Glycerophospholipid fatty acids (GPL-FA), polar lipids, non-esterified fatty acids (NEFA), and amino acids were analyzed with a targeted, liquid chromatography-tandem mass spectrometry based metabolomics platform. Cord blood metabolites were related to growth factors by linear regression models adjusted for confounding variables. Results: Cord blood metabolites were highly associated with birth weight. Lysophosphatidylcholines C16:1, C18:1, C20:3, C18:2, C20:4, C14:0, C16:0, C18:3, GPL-FA C20:3n-9, and GPL-FA C22:5n-6 were positively related to birth weight, while higher cord blood concentrations of NEFA C22:6, NEFA C20:5, GPL-FA C18:3n-3, and PCe C38:0 were associated with lower birth weight. Postnatal weight gain and BMI z-scores in adolescents were not significantly associated with cord blood metabolites after adjustment for multiple testing. Conclusion: Potential long-term programming effects of the intrauterine environment and metabolism on later health cannot be predicted with profiling of the cord blood metabolome.
“…Hence different phenotypes can originate from the same genotype due to environmental stimuli via mechanisms such as epigenetic modifications [3]. For example, it has been proposed that intrauterine undernutrition can cause changes in endocrine response, body size, and composition as the fetus adapts to encounter the threat to survival [4,5]. Low birth weight and subsequent catch-up growth have both been associated with increased risk for later-life overweight [6,7] and higher susceptibility to related diseases such as cardiovascular disease [8] and diabetes [9].…”
Background/Aims: Fetal metabolism may be changed by the exposure to maternal factors, and the route to obesity may already set in utero. Cord blood metabolites might predict growth patterns and later obesity. We aimed to characterize associations of cord blood with birth weight, postnatal weight gain, and BMI in adolescence. Methods: Over 700 cord blood samples were collected from infants participating in the German birth cohort study LISAplus. Glycerophospholipid fatty acids (GPL-FA), polar lipids, non-esterified fatty acids (NEFA), and amino acids were analyzed with a targeted, liquid chromatography-tandem mass spectrometry based metabolomics platform. Cord blood metabolites were related to growth factors by linear regression models adjusted for confounding variables. Results: Cord blood metabolites were highly associated with birth weight. Lysophosphatidylcholines C16:1, C18:1, C20:3, C18:2, C20:4, C14:0, C16:0, C18:3, GPL-FA C20:3n-9, and GPL-FA C22:5n-6 were positively related to birth weight, while higher cord blood concentrations of NEFA C22:6, NEFA C20:5, GPL-FA C18:3n-3, and PCe C38:0 were associated with lower birth weight. Postnatal weight gain and BMI z-scores in adolescents were not significantly associated with cord blood metabolites after adjustment for multiple testing. Conclusion: Potential long-term programming effects of the intrauterine environment and metabolism on later health cannot be predicted with profiling of the cord blood metabolome.
“…Further studies in Finland and India replicated these findings [15][16][17]. Various studies have demonstrated that rapid postnatal weight gain in newborns with an initial low birth weight is mainly due to fat accumulation and not due to an increase in muscle mass [18][19][20]. This specific phenotype was observed in several cohorts of small for gestational age newborns [21,22].…”
The concept of developmental origins of diseases has gained a huge interest in recent years and is a constantly emerging scientific field. First observations hereof originated from epidemiological studies, linking impaired birth outcomes to adult chronic, noncommunicable disease. By now there is a considerable amount of both epidemiological and experimental evidence highlighting the impact of early life events on later life disease susceptibility. Albeit far from being completely understood, more recent studies managed to elucidate underlying mechanisms, with epigenetics having become almost synonymous with developmental programming. The aim of this review was to give a comprehensive overview of various aspects and mechanisms of developmental origins of diseases. Starting from initial research foci mainly centered on a nutritionally impaired intrauterine environment, more recent findings such as postnatal nutrition, preterm birth, paternal programming and putative interventional approaches are summarized. The review outlines general underlying mechanisms and particularly discusses mechanistic explanations for sexual dimorphism in developmental programming. Furthermore, novel hypotheses are presented emphasizing a non-mendelian impact of parental genes on the offspring's phenotype.
“…Esses achados são semelhantes aos da metanálise publicada por Johnson et al 18 em 2012, que também verificaram maior porcentagem de gordura corporal entre os RNPT, principalmente às custas de menor massa livre de gordura. Um aumento da massa de gordura pode estar associado ao desenvolvimento futuro de doenças crônicas não transmissíveis do adulto, como obesidade, diabetes, hipercolesterolemia e hipertensão arterial, que têm sido descritos em recém-nascidos que sofreram restrição de crescimento 33 .…”
Section: I S C U S S ã Ounclassified
“…Nesse estudo citado, os RNPT foram divididos em três grupos, e os que nasceram pequenos para idade gestacional e os que apresentaram restrição do crescimento pós-natal apresentaram um ganho maior de massa de gordura que os sem restrição do crescimento pós-natal. No período pós-natal imediato, os RNPT acumulam mais gordura que os a termo e apresentam a recuperação da massa de gordura mais precocemente que a recuperação do peso e comprimento 33 .…”
Antropometria e composição corporal de recém-nascidos pré-termo na idade gestacional e no peso equivalente ao termo
Anthropometry and body composition of preemies at term age and term age weight
R E S U M O ObjetivoAnalisar o crescimento e a composição corporal de recém-nascidos pré-termo na idade gestacional corrigida de termo e ao alcançarem um peso entre 3,0 e 3,5 kg.
MétodosEstudo longitudinal, realizado no Instituto Fernandes Figueira, Rio de Janeiro, com 39 recém-nascidos pré-termo e que apresentaram muito baixo peso ao nascer. Medidas antropométricas e água corporal total foram avaliadas no primeiro, no sétimo e no dia da recuperação do peso de nascimento, na idade gestacional corrigida do termo e em torno de três semanas de idade gestacional corrigida (correspondente ao tempo de vida para alcançar um peso entre 3,0 e 3,5 kg). O grupo de referência foi constituído por 32 recém-nascidos a termo, adequados para a idade gestacional, avaliados no segundo dia de vida. Considerou-se restrição de crescimento o escore-Z menor do que -2 para peso, comprimento e perímetro cefálico.
ResultadosNa idade de termo, 71,8% dos recém-nascidos pré-termo apresentaram restrição do crescimento para peso, 61,5% para comprimento e 25,6% para perímetro cefálico. Com três semanas de idade gestacional corrigida, esses recém-nascidos apresentaram a prega cutânea tricipital e a circunferência abdominal estatisticamente maiores que o grupo de referência enquanto o comprimento e a porcentagem de água corporal total foram menores.
ConclusãoOs recém-nascidos pré-termo apresentaram perfil antropométrico e de água corporal diferente dos recém--nascidos a termo, sugerindo acúmulo de gordura. Houve recuperação do crescimento entre a idade de termo e três semanas de idade corrigida, sendo mais evidente esse crescimento em relação ao perímetro cefálico e peso.Palavras-chave: Antropometria. Composição corporal. Prematuro. Recém-nascido.
A B S T R A C T
ObjectiveTo analyze growth and body composition of preemies at term gestational age and when they reach a weight of 3.0 to 3.5 kg.
Methods
This longitudinal study was conducted at
ConclusionThe anthropometric profile and total body water of preemies were different from those of term newborns, suggesting fat deposition. There was catch up growth between term age and three weeks of corrected gestational age, which was more evident for head circumference and weight.
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