Early postmenopausal women with cardiovascular risk factors improve microvascular dysfunction after acute estradiol administration

Clapauch, Ruth; Mecenas, Anete Souza; Maranhão, Priscila Alves

doi:10.1097/gme.0b013e31823a8f43

Cited by 7 publications

(3 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Videocapillaroscopy results were similar between HD and healthy women, except for time to reach maximum red blood cell velocity before estradiol (TRBCV max1 ), which was shorter in HD women, as previously described [36], probably due to higher vascular wall stiffness, denoting some degree of atherosclerotic infiltration. Nevertheless, women with CV risk factors in early postmenopausal years showed to retain an endothelial function comparable to healthy ones.…”

Section: Discussionsupporting

confidence: 83%

Endothelial Function and Insulin Resistance in Early Postmenopausal Women with Cardiovascular Risk Factors: Importance of ESR1 and NOS3 Polymorphisms

et al. 2014

Self Cite

View full text Add to dashboard Cite

Cardiovascular benefits from estradiol activation of nitric oxide endothelial production may depend on vascular wall and on estrogen receptor alpha (ESR1) and nitric oxide synthase (NOS3) polymorphisms. We have evaluated the microcirculation in vivo through nailfold videocapillaroscopy, before and after acute nasal estradiol administration at baseline and after increased sheer stress (postocclusive reactive hyperemia response) in 100 postmenopausal women, being 70 controls (healthy) and 30 simultaneously hypertensive and diabetic (HD), correlating their responses to PvuII and XbaI ESR1 polymorphisms and to VNTR, T-786C and G894T NOS3 variants. In HD women, C variant allele of ESR1 Pvull was associated to higher vasodilatation after estradiol (1.72 vs 1.64 mm/s, p = 0.01 compared to TT homozygotes) while G894T and T-786C NOS3 polymorphisms were connected to lower increment after shear stress (15% among wild type and 10% among variant alleles, p = 0.02 and 0.04). The G variant allele of ESR1 XbaI polymorphism was associated to higher HOMA-IR (3.54 vs. 1.64, p = 0.01) in HD and higher glucose levels in healthy women (91.8 vs. 87.1 mg/dl, p = 0.01), in which increased waist and HOMA-IR were also related to the G allele in NOS3 G894T (waist 93.5 vs 88.2 cm, p = 0.02; HOMA-IR 2.89 vs 1.48, p = 0.05). ESR1 Pvull, NOS3 G894T and T-786C polymorphism analysis may be considered in HD postmenopausal women for endothelial response prediction following estrogen therapy but were not discriminatory for endothelial response in healthy women. ESR1 XbaI and G894T NOS3 polymorphisms may be useful in accessing insulin resistance and type 2 diabetes risks in all women, even before menopause and occurrence of metabolic disease.

show abstract

Section: Discussionsupporting

confidence: 83%

Endothelial Function and Insulin Resistance in Early Postmenopausal Women with Cardiovascular Risk Factors: Importance of ESR1 and NOS3 Polymorphisms

et al. 2014

Self Cite

View full text Add to dashboard Cite

show abstract

“…The association between hypoestrogenism and endothelial dysfunction is well established (1) as well the beneficial effects of estrogen administration on endothelium (20) in early post menopause.…”

Section: Discussionmentioning

confidence: 99%

Low testosterone levels are associated with endothelial dysfunction in oophorectomized early postmenopausal women

Rech

Clapauch

Souza

2016

European Journal of Endocrinology

Self Cite

View full text Add to dashboard Cite

Background: The actual consequences of low testosterone levels in women remain uncertain. Objective: To assess endogenous testosterone influence on body composition, vascular and metabolic function in recent postmenopausal women. Design: We studied 81 postmenopausal women under transdermal estradiol (E 2 ) replacement therapy, 36 with bilateral oophorectomy (group O), and 45 controls (group C) through venous occlusion plethysmography, bioimpedance, DEXA, biochemical, hormonal, and inflammatory profile. Results: Total testosterone level (TT) in group O was 11.0 (4.0-17.75) vs 23.0 (10.0-42.5) ng/dl in group C (PZ0.001). Forearm blood flow, in ml/min/100 ml tissue, was lower in group O compared to group C at baseline (1.57 (1.05-2.47) vs 2.19 (1.59-2.66) PZ0.036), following reactive hyperemia response (endothelium-dependent flow mediated dilatation, 3.44 (2.38-4.35) vs 4.3 (3.09-5.52), PZ0.031) and following nitroglycerin (endothelium-independent dilation, 1.39 (0.99-1.7) vs 1.76 (1.15-2.0), PZ0.025), with a positive correlation between TT and all parameters except for the reactive hyperemia response (rZ0.233-0.312, PZ0.036-0.004). The sVCAM1 levels were negatively correlated with TT (rZ-0.320, PZ0.005). E 2 and other hormone levels, biochemical parameters and body composition did not differ between groups. Multiple linear regressions showed that the levels of TT, compared with other confounding variables, may explain the variation observed on endothelial parameters, with low explanatory power. Conclusion: The absence of ovarian testosterone production in recent postmenopausal oophorectomized women was associated with deleterious effects on endothelial function.

show abstract

“…Anthropometric, blood pressure (BP), and laboratory measurements were well-validated as previously reported [4,6,7,15,23]. The body weight of subjects wearing light clothing without shoes was measured with a 0.1-kg precision, height was measured to the nearest 0.5 cm, and BMI was calculated as the weight in kilograms divided by the square of height in meters.…”

Section: Methodsmentioning

confidence: 99%

Obesity, metabolic syndrome, impaired fasting glucose, and microvascular dysfunction: a principal component analysis approach

Panazzolo

Sicuro

Clapauch

et al. 2012

BMC Cardiovasc Disord

Self Cite

View full text Add to dashboard Cite

BackgroundWe aimed to evaluate the multivariate association between functional microvascular variables and clinical-laboratorial-anthropometrical measurements.MethodsData from 189 female subjects (34.0±15.5 years, 30.5±7.1 kg/m2), who were non-smokers, non-regular drug users, without a history of diabetes and/or hypertension, were analyzed by principal component analysis (PCA). PCA is a classical multivariate exploratory tool because it highlights common variation between variables allowing inferences about possible biological meaning of associations between them, without pre-establishing cause-effect relationships. In total, 15 variables were used for PCA: body mass index (BMI), waist circumference, systolic and diastolic blood pressure (BP), fasting plasma glucose, levels of total cholesterol, high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), triglycerides (TG), insulin, C-reactive protein (CRP), and functional microvascular variables measured by nailfold videocapillaroscopy. Nailfold videocapillaroscopy was used for direct visualization of nutritive capillaries, assessing functional capillary density, red blood cell velocity (RBCV) at rest and peak after 1 min of arterial occlusion (RBCVmax), and the time taken to reach RBCVmax (TRBCVmax).ResultsA total of 35% of subjects had metabolic syndrome, 77% were overweight/obese, and 9.5% had impaired fasting glucose. PCA was able to recognize that functional microvascular variables and clinical-laboratorial-anthropometrical measurements had a similar variation. The first five principal components explained most of the intrinsic variation of the data. For example, principal component 1 was associated with BMI, waist circumference, systolic BP, diastolic BP, insulin, TG, CRP, and TRBCVmax varying in the same way. Principal component 1 also showed a strong association among HDL-c, RBCV, and RBCVmax, but in the opposite way. Principal component 3 was associated only with microvascular variables in the same way (functional capillary density, RBCV and RBCVmax). Fasting plasma glucose appeared to be related to principal component 4 and did not show any association with microvascular reactivity.ConclusionsIn non-diabetic female subjects, a multivariate scenario of associations between classic clinical variables strictly related to obesity and metabolic syndrome suggests a significant relationship between these diseases and microvascular reactivity.

show abstract

Early postmenopausal women with cardiovascular risk factors improve microvascular dysfunction after acute estradiol administration

Cited by 7 publications

References 43 publications

Endothelial Function and Insulin Resistance in Early Postmenopausal Women with Cardiovascular Risk Factors: Importance of ESR1 and NOS3 Polymorphisms

Endothelial Function and Insulin Resistance in Early Postmenopausal Women with Cardiovascular Risk Factors: Importance of ESR1 and NOS3 Polymorphisms

Low testosterone levels are associated with endothelial dysfunction in oophorectomized early postmenopausal women

Obesity, metabolic syndrome, impaired fasting glucose, and microvascular dysfunction: a principal component analysis approach

Contact Info

Product

Resources

About