Early post-operative magnetic resonance imaging in glioblastoma: correlation among radiological findings and overall survival in 60 patients

Majós, Carles; Cos, Mònica; Castañer, Sara; Gil, Miguel; Plans, Gerard; Lucas, Anna; Bruna, Jordi; Aguilera, Carles

doi:10.1007/s00330-015-3914-x

Cited by 31 publications

(30 citation statements)

References 16 publications

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“…Some well-known prognostic factors are patient age, performance status, neurologic function, mental status, MGMT promoter methylation status, and extent of tumor resection. 5,11,12,[15][16][17][18][19][20][21][22] The evolution of the tumor between EPMR and PRMR could provide information about proliferative behavior that might lead to additional predictive information about the outcome after therapy. Our study provides a positive argument for this possibility.…”

Section: Discussionmentioning

confidence: 99%

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Preradiotherapy MR Imaging: A Prospective Pilot Study of the Usefulness of Performing an MR Examination Shortly before Radiation Therapy in Patients with Glioblastoma

Majós

Cos²,

Castañer³

et al. 2016

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE:Current protocols in patients with glioblastoma include performing an MR examination shortly after surgery and then 2-6 weeks after ending concomitant chemoradiotherapy. The assessment of this first postradiotherapy examination is challenging because the pseudoprogression phenomenon may appear. The aim of this study was to explore if performing an MR examination shortly before radiation therapy (preradiotherapy MR imaging) could improve the radiologic assessment of patients with glioblastoma.

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Section: Discussionmentioning

confidence: 99%

“…11,12 Patients were stratified into 3 groups according to the extent of tumor resection: total resection, subtotal resection between 95%-100%, and subtotal resection Ͻ95%.…”

Section: Mr Imagingmentioning

confidence: 99%

Preradiotherapy MR Imaging: A Prospective Pilot Study of the Usefulness of Performing an MR Examination Shortly before Radiation Therapy in Patients with Glioblastoma

Majós

Cos²,

Castañer³

et al. 2016

AJNR Am J Neuroradiol

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“…Previous studies have evaluated the patterns of contrast enhancement on early post-operative MR (EPMR) examinations within three days of surgery, following the recommendation of Ekinci et al[11, 12, 21]. Majos et al[12] demonstrated that GBM patients with thin-linear enhancement pattern survived longer than those with thick-linear or nodular enhancement patterns (median overall survival: thin linear = 609 days, thick linear = 432 days, and nodular = 318 days).…”

Section: Discussionmentioning

confidence: 99%

“…Majos et al[12] demonstrated that GBM patients with thin-linear enhancement pattern survived longer than those with thick-linear or nodular enhancement patterns (median overall survival: thin linear = 609 days, thick linear = 432 days, and nodular = 318 days). Accordingly, this study suggested that a thin-linear enhancement pattern on EPMR could be considered a benign and favorable finding.…”

Section: Discussionmentioning

confidence: 99%

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MR Imaging Analysis of Non-Measurable Enhancing Lesions Newly Appearing after Concomitant Chemoradiotherapy in Glioblastoma Patients for Prognosis Prediction

et al. 2016

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PurposeTo analyze the enhancement patterns and apparent diffusion coefficient (ADC) values of non-measurable surgical cavity wall enhancement pattern, newly appearing after completion of standard concurrent chemoradiotherapy (CCRT) with temozolomide in glioblastoma patients for the prognosis prediction.Materials and MethodsFrom January 2010 to April 2014, among 190 patients with histopathologically confirmed glioblastoma, a total of 33 patients with non-measurable wall enhancement on post-CCRT MR imaging were enrolled and divided into two subgroups: non-progression (n = 18) and progression groups (n = 15). We analyzed the wall enhancement patterns, which were categorized into three patterns: thin, thick and nodular enhancement. ADC values were measured in the enhancing portions of the walls. The progression-free survival (PFS) related to the wall enhancement was analyzed by Kaplan-Meier analysis, and survival curves were compared using the log-rank test.ResultsStatistically significant differences in the surgical cavity wall enhancement patterns was shown between the progression and non-progression groups (P = 0.0032). Thin wall enhancement was more frequently observed in the non-progression group, and thick or nodular wall enhancement were observed in the progression group (P = 0.0016). There was no statistically significant difference in the mean ADC values between the progression and non-progression groups. The mean PFS was longer in patients with thin wall enhancement than in those with nodular or thick wall enhancement (35.5 months vs. 15.8 months, P = 0.008).ConclusionPattern analysis of non-measurable surgical cavity wall enhancement on post-CCRT MR imaging might be useful tool for predicting prognosis of GBM patient before clear progression of non-measurable disease.

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Comparison of EPI DWI and STEAM DWI in Early Postoperative MRI Controls After Resection of Tumors of the Central Nervous System

Müller

Khadhraoui

Voit³

et al. 2023

Clin Neuroradiol

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Purpose Diffusion-weighted imaging (DWI) is important for differentiating residual tumor and subacute infarctions in early postoperative magnetic resonance imaging (MRI) of central nervous system (CNS) tumors. In cases of pneumocephalus and especially in the presence of intraventricular trapped air, conventional echo-planar imaging (EPI) DWI is distorted by susceptibility artifacts. The performance and robustness of a newly developed DWI sequence using the stimulated echo acquisition mode (STEAM) was evaluated in patients after neurosurgical operations with early postoperative MRI. Methods We compared EPI and STEAM DWI of 43 patients who received 3‑Tesla MRI within 72 h after a neurosurgical operation between 1 October 2019 and 30 September 2021. We analyzed susceptibility artifacts originating from air and blood and whether these artifacts compromised the detection of ischemic changes after surgery. The DWI sequences were (i) visually rated and (ii) volumetrically analyzed. Results In 28 of 43 patients, we found severe and diagnostically relevant artifacts in EPI DWI, but none in STEAM DWI. In these cases, in which artifacts were caused by intracranial air, they led to a worse detection of ischemic lesions and thus to a possible failed diagnosis or lack of judgment using EPI DWI. Additionally, volumetric analysis demonstrated a 14% smaller infarct volume detected with EPI DWI. No significant differences in visual rating and volumetric analysis were detected among the patients without severe artifacts. Conclusion The newly developed version of STEAM DWI with highly undersampled radial encodings is superior to EPI DWI in patients with postoperative pneumocephalus.

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Early post-operative magnetic resonance imaging in glioblastoma: correlation among radiological findings and overall survival in 60 patients

Cited by 31 publications

References 16 publications

Preradiotherapy MR Imaging: A Prospective Pilot Study of the Usefulness of Performing an MR Examination Shortly before Radiation Therapy in Patients with Glioblastoma

Preradiotherapy MR Imaging: A Prospective Pilot Study of the Usefulness of Performing an MR Examination Shortly before Radiation Therapy in Patients with Glioblastoma

MR Imaging Analysis of Non-Measurable Enhancing Lesions Newly Appearing after Concomitant Chemoradiotherapy in Glioblastoma Patients for Prognosis Prediction

Comparison of EPI DWI and STEAM DWI in Early Postoperative MRI Controls After Resection of Tumors of the Central Nervous System

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