Early-phase insulin hypersecretion associated with weight loss outcome after LSG: a prospective cohort study in Asian patients with BMI ≥28 kg/m2

Guo, Lu; Luo, Wenjin; Tan, Tao; Gong, Faping; Liu, Xiurong; Rao, Siqi; Lian, Fei; Liu, Jia; Chen, Xiangjun; Li, Guochuan; Yang, Zhiyou; Mei, Mei; Hu, Jinbo; Li, Qifu; Wang, Zhihong; Zhang, Jun; Zeng, Menghua; Gong, Lilin

doi:10.1016/j.soard.2022.05.013

Cited by 5 publications

(3 citation statements)

References 27 publications

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“…Lu Guo et al similarly found that patients with HINS lost less weight after treatment with LSG. 19 HINS is an important proinflammatory factor in patients with obesity, promoting the development of chronic inflammation in adipose tissue and affecting local or systemic metabolic function in patients with obesity. 6 , 20 Inflammation and impaired metabolism of adipose tissue are closely related to the development of obesity.…”

Section: Discussionmentioning

confidence: 99%

Hyperinsulinemia Influences the Short-Term Efficiency of Laparoscopic Sleeve Gastrectomy for Patients with Obesity and Insulin Resistance

Yue¹,

Qian²,

Yan³

et al. 2023

DMSO

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Purpose The effect of hyperinsulinemia on short-term outcomes after laparoscopic sleeve gastrectomy (LSG) in patients with obesity combined with insulin resistance is unclear. Material and Methods This was a retrospective analysis of patients who underwent LSG at our center between January 1, 2020, and December 31, 2021. Patients were divided into hyperinsulinemia (HINS) and nonhyperinsulinemia (NHINS) groups based on fasting insulin levels. The primary endpoint was weight change. Metabolic disease outcomes, postoperative complications, and quality of life score changes were secondary endpoints. Results A total of 92 patients were included in this study, with 59 in the HINS group and 33 in the NHINS group. At 6 months postoperatively, the median (P 25 , P 75 ) %EWL was 76.01 (64.40, 86.99)% in the HINS group and 92.02 (86.78, 100.88)% in the NHINS group (P<0.001). The mean %TWL (SD) was 23.26 (7.14)% in the HINS group and 26.80 (6.55)% in the NHINS group (P=0.021). The remission of dyslipidemia and hypertension in the NHINS group and the HINS group were not significantly different (P>0.05 for all). The differences in QOL between groups were not statistically significant (P=0.788). In terms of postoperative complications, there was no statistically significant difference between the groups (P>0.05 for all). Conclusion HINS negatively influences weight change in patients with obesity and insulin resistance, and the NHINS group had better postoperative weight loss. In terms of hypertension, dyslipidemia, and postoperative complications, there was no significant effect of HINS.

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Section: Discussionmentioning

confidence: 99%

Hyperinsulinemia Influences the Short-Term Efficiency of Laparoscopic Sleeve Gastrectomy for Patients with Obesity and Insulin Resistance

Yue¹,

Qian²,

Yan³

et al. 2023

DMSO

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show abstract

“…The ideal BMI value of 25 kg/m 2 was accepted and the ideal weight value of the patients was calculated with 25×height 2 (m 2 ). TWL% value was calculated as follows: (initial weight (kg)–first-year weight)×100/initial weight (kg) 19 …”

Section: Methodsmentioning

confidence: 99%

“…TWL% value was calculated as follows: (initial weight (kg)-first-year weight)×100/ initial weight (kg). 19…”

Section: Success Of Weight Loss After Lsg and Formulasmentioning

confidence: 99%

Development and Validation of the GAASThyriC Model for Predicting Patients with Suboptimal Clinical Response After Laparoscopic Sleeve Gastrectomy and a Practical Calculator: A Retrospective Cohort Study

Demirpolat,

İslam

2024

Surgical Laparoscopy, Endoscopy &Amp; Percutaneous Techniques

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Background: It might not be possible to achieve the desired outcome in every patient following bariatric surgery, even though every patient is thoroughly examined before surgery. This study aimed to develop a regression model based on parameters that affect weight loss success in patients scheduled for laparoscopic sleeve gastrectomy (LSG) and thus preoperatively predict whether the patients will have an optimal clinical response in terms of weight loss at the end of the first year. Materials and Methods: Between January 2018 and August 2022, patients who underwent LSG were analyzed retrospectively. Age, sex, comorbidities, smoking status, alcohol use status, preoperative weight, preoperative body mass index (BMI), preoperative laboratory data, weight, and total weight loss (TWL)% values at the end of the first year were recorded. At the end of the first year following LSG, patients with TWL% above 20% were defined as having an optimal clinical response in terms of weight loss. This study is designed, conducted, and reported regarding the “transparent reporting of a multivariable prediction model for individual prognosis or diagnosis” (TRIPOD) statement. The final model was used to construct an Excel-based calculator. Results: Four hundred thirty-eight patients underwent the sleeve gastrectomy procedure, and 38 of them were excluded from the study because of a lack of 1-year follow-up information, resulting in 400 eligible patients for our study. Age, glucose, thyroid stimulating hormone (TSH), alcohol consumption, systemic immune inflammation index (SII), and tobacco were the independent predictors of optimal clinical response (P<0.001, P<0.001, P<0.001, P=0.011, P=0.039, P=0.045, respectively). The model was called the GAASThyriC score. When the final model was tested in the validation cohort, the AUC was 0.875 (95% CI, 0.742-0.999), the sensitivity was 83.3% (95% CI, 51.6-97.9), specificity was 86.4% (95% CI, 77.4-92.8), negative likelihood ratio was 0.19 (95% CI, 0.05-0.68), and accuracy was 86% (95% CI, 77.6-92.1) when the cutoff value was set to the optimal threshold (logit = 0.8451). Conclusion: The GAASThyriC score can be used as an effective auxiliary tool to predict the patient population with suboptimal clinical response in terms of TWL% at the end of the first year after LSG.

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Short-Term Changes in Weight, Body Composition, and Metabolic Biomarkers After Laparoscopic Sleeve Gastrectomy in Patients with Obesity: A Comparative Prospective Study

Hong,

Tang,

Hao

et al. 2024

OBES SURG

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Early-phase insulin hypersecretion associated with weight loss outcome after LSG: a prospective cohort study in Asian patients with BMI ≥28 kg/m2

Cited by 5 publications

References 27 publications

Hyperinsulinemia Influences the Short-Term Efficiency of Laparoscopic Sleeve Gastrectomy for Patients with Obesity and Insulin Resistance

Hyperinsulinemia Influences the Short-Term Efficiency of Laparoscopic Sleeve Gastrectomy for Patients with Obesity and Insulin Resistance

Development and Validation of the GAASThyriC Model for Predicting Patients with Suboptimal Clinical Response After Laparoscopic Sleeve Gastrectomy and a Practical Calculator: A Retrospective Cohort Study

Short-Term Changes in Weight, Body Composition, and Metabolic Biomarkers After Laparoscopic Sleeve Gastrectomy in Patients with Obesity: A Comparative Prospective Study

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