Early-Phase Enhanced Inflammatory Reaction After Spinal Instrumentation Surgery

Takahashi, J.; Ebara, Sohei; Kamimura, Mikio; Kinoshita, Tetsuya; Itoh, Hidehiro; Yuzawa, Yukio; Sheena, Yo; Takaoka, Kunio

doi:10.1097/00007632-200108010-00014

Cited by 88 publications

(124 citation statements)

References 33 publications

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“…2, Table 2). Moreover, the difference in CRP levels between the two groups was similar to that observed between patients undergoing instrumented and non-instrumented spinal surgery [29], supporting the role of CRP as an indicator of the intensity of the inflammatory reaction to surgery and of the efficiency of the preoperative treatment with N+F [8].…”

Section: Effect Of the Treatment On Inflammatory Mediatorssupporting

confidence: 54%

“…However, although in different types of orthopaedic surgery CRP levels remained consistently elevated (10-20 mg/dl) between 48 and 72 postoperative hours [11,29,31], postoperative IL-6 time-courses were variable, even for a particular surgery, both in the concentrations attained and in the time to reach peak values (4-24 h) [11,13,33]. Hence, since IL-6 was not determined at 6-8 postoperative hours, a possible significant difference between groups in IL-6 levels at that time can not be excluded.…”

Section: Effect Of the Treatment On Inflammatory Mediatorsmentioning

confidence: 98%

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Acute phase response in patients undergoing lumbar spinal surgery: modulation by perioperative treatment with naproxen and famotidine

et al. 2003

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Section: Effect Of the Treatment On Inflammatory Mediatorssupporting

confidence: 54%

Section: Effect Of the Treatment On Inflammatory Mediatorsmentioning

confidence: 98%

Acute phase response in patients undergoing lumbar spinal surgery: modulation by perioperative treatment with naproxen and famotidine

et al. 2003

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“…Most authors found that CRP value was more sensitive than ESR or WBC for different types of SSI. CRP level was a highly sensitive factor for infection [18][19][20], with 96.8% of deep and 100% of superficial SSIs having elevated levels. WBC count has been a less reliable indicator for infection.…”

Section: Diagnosismentioning

confidence: 99%

Infections in spinal instrumentation

Gerometta

Olaverri

Bitan

2012

International Orthopaedics (SICOT)

126

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Surgical-site infection (SSI ) in the spine is a serious postoperative complication. Factors such as posterior surgical approach, arthrodesis, use of spinal instrumentation, age, obesity, diabetes, tobacco use, operating-room environment and estimated blood loss are well established in the literature to affect the risk of infection. Infection after spine surgery with instrumentation is becoming a common pathology. The reported infection rates range from 0.7% to 11.9%, depending on the diagnosis and complexity of the procedure. Besides operative factors, patient characteristics could also account for increased infection rates. These infections after instrumented spinal fusion are particularly difficult to manage due to the implanted, and possibly infected, instrumentation. Because the medical, economic and social costs of SSI after spinal instrumentation are enormous, any significant reduction in risks will pay dividends. The goal of this literature review was to analyse risk factors, causative organisms, diagnostic elements (both clinical and biological), different treatment options and their efficiency and consequences and the means of SSI prevention.

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“…And so, papers regarding postoperative control of fusion surgery have been published. Some detailed reports have been published regarding the inflammatory reactions that occur after spinal instrumentation surgery (Takahashi et al 2001(Takahashi et al , 2006. Other reports have addressed the issues of bleeding volume and anemia following posterior fusion surgery (Behrman and Keim 1992;Gause et al 2008).…”

mentioning

confidence: 99%

Postoperative Anemia Following Posterior Decompression Surgery for Lumbar Spinal Canal Stenosis

Sasaji¹,

Horaguchi²,

Shinozaki³

et al. 2013

Tohoku J. Exp. Med.

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The incidence of lumbar spinal canal stenosis (LSCS) is increasing in Japan. Posterior lumbar decompression surgery, wide fenestration and laminectomy, for LSCS is a common treatment modality. Compared with posterior fusion surgery, posterior decompression surgery has been considered as less invasive. However, no reports regarding postoperative anemia following posterior decompression surgery have been published. In this retrospective study, we evaluated changes in hemoglobin values following wide fenestration in 80 patients with LSCS based on the number of operated levels, and also analyzed the differences between intraoperative and postoperative bleeding volume. Two patients required allogenic transfusion. The mean preoperative hemoglobin values were 13.6 g/dL and the mean postoperative minimum hemoglobin values were 11.2 g/dL. The mean hemoglobin values decreased by 1.8 g/dL in patients with one operated level (n = 15); 2.2 g/dL in those with two operated levels (n = 31); 2.6 g/dL in those with three operated levels (n = 23); and 3 g/dL in those with four operated levels (n = 11). The mean decrease in hemoglobin values was calculated as follows: 1.8 + 0.4 × (X − 1), where X was the number of operated levels. The mean intraoperative bleeding volume was 94 ml and the mean postoperative bleeding volume was 418 ml. Postoperative bleeding volume was significantly larger than intraoperative bleeding volume. Accordingly, postoperative hemoglobin values can be predicted in patients undergoing wide fenestration. Effective management of postoperative bleeding is necessary to prevent postoperative anemia.

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Early-Phase Enhanced Inflammatory Reaction After Spinal Instrumentation Surgery

Cited by 88 publications

References 33 publications

Acute phase response in patients undergoing lumbar spinal surgery: modulation by perioperative treatment with naproxen and famotidine

Acute phase response in patients undergoing lumbar spinal surgery: modulation by perioperative treatment with naproxen and famotidine

Infections in spinal instrumentation

Postoperative Anemia Following Posterior Decompression Surgery for Lumbar Spinal Canal Stenosis

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