Early‐phase amyloid PET reproduces metabolic signatures of cognitive decline in Parkinson's disease
William W. T. Aye,
Megan R. Stark,
Kyla‐Louise Horne
et al.
Abstract:INTRODUCTIONRecent work suggests that amyloid beta (Aβ) positron emission tomography (PET) tracer uptake shortly after injection (“early phase”) reflects brain metabolism and perfusion. We assessed this modality in a predominantly amyloid‐negative neurodegenerative condition, Parkinson's disease (PD), and hypothesized that early‐phase 18F‐florbetaben (eFBB) uptake would reproduce characteristic hypometabolism and hypoperfusion patterns associated with cognitive decline in PD.METHODSOne hundred fifteen PD patie… Show more
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