Early perfusion after controlled cortical impact in rats: Quantification by arterial spin-labeled MRI and the influence of spin-lattice relaxation time heterogeneity

Hendrich, Kristy; Kochanek, Patrick M.; Williams, Donald S.; Schiding, Joanne K.; Marion, Donald W.; Ho, Chien

doi:10.1002/(sici)1522-2594(199910)42:4<673::aid-mrm8>3.0.co;2-b

Cited by 63 publications

(63 citation statements)

References 36 publications

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“…There are now at least four different variations on ASL including continuous ASL (CASL) (Detre and Alsop, 1999), pulsed ASL (PASL), cPASL (continuous PASL), and velocity selected ASL (VSASL) . ASL has been used to study rodent models of TBI (Forbes et al, 1997a,b;Hendrich et al, 1999;Kochanek et al, 2002Kochanek et al, , 2005Robertson et al, 2000), and has recently also been used in patient studies . Several promising potential applications for ASL in the study of TBI have been proposed, including characterization of regional brain function in severe TBI in which task-evoked responses are difficult to obtain, determination of the relationship between changes in regional CBF and cognitive deficits to identify potential targets for pharmacological therapy or other intervention, and use as a biomarker for pharmaceutical trials (Van Boven et al, 2009).…”

Section: Perfusion Imagingmentioning

confidence: 99%

Emerging Imaging Tools for Use with Traumatic Brain Injury Research

Hunter

Wilde

Tong

et al. 2012

Journal of Neurotrauma

114

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This article identifies emerging neuroimaging measures considered by the inter-agency Pediatric Traumatic Brain Injury (TBI) Neuroimaging Workgroup. This article attempts to address some of the potential uses of more advanced forms of imaging in TBI as well as highlight some of the current considerations and unresolved challenges of using them. We summarize emerging elements likely to gain more widespread use in the coming years, because of 1) their utility in diagnosis, prognosis, and understanding the natural course of degeneration or recovery following TBI, and potential for evaluating treatment strategies; 2) the ability of many centers to acquire these data with scanners and equipment that are readily available in existing clinical and research settings; and 3) advances in software that provide more automated, readily available, and cost-effective analysis methods for large scale data image analysis. These include multi-slice CT, volumetric MRI analysis, susceptibility-weighted imaging (SWI), diffusion tensor imaging (DTI), magnetization transfer imaging (MTI), arterial spin tag labeling (ASL), functional MRI (fMRI), including resting state and connectivity MRI, MR spectroscopy (MRS), and hyperpolarization scanning. However, we also include brief introductions to other specialized forms of advanced imaging that currently do require specialized equipment, for example, single photon emission computed tomography (SPECT), positron emission tomography (PET), encephalography (EEG), and magnetoencephalography (MEG)/magnetic source imaging (MSI). Finally, we identify some of the challenges that users of the emerging imaging CDEs may wish to consider, including quality control, performing multi-site and longitudinal imaging studies, and MR scanning in infants and children.

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Section: Perfusion Imagingmentioning

confidence: 99%

Emerging Imaging Tools for Use with Traumatic Brain Injury Research

Hunter

Wilde

Tong

et al. 2012

Journal of Neurotrauma

114

View full text Add to dashboard Cite

show abstract

“…Similarly, as a result of head trauma or intracranial disease, CBF can become blood pressure dependent in the range that is normally highly regulated, leading to a secondary brain injury. Ischemia commonly results in secondary injury, and can have significant acute effects in stroke (2,3) and traumatic brain injury (TBI) (4,5). Chronic effects of ischemia can also be observed in Alzheimer's disease (6,7).…”

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confidence: 99%

Murine orthostatic response during prolonged vertical studies: Effect on cerebral blood flow measured by arterial spin‐labeled MRI

Foley

Hitchens

Kochanek

et al. 2005

Magnetic Resonance in Med

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“…Disturbances in cerebral blood flow (CBF are also a common sequela of head injury and have been documented both experimentally (Yamakami and McIntosh, 1991;Bryan et al, 1995;Kochanek et al, 1995;Forbes et al, 1997;Hendrich et al, 1999;Lythgoe et al, 2003) and clinically (Bouma et al, 1991;Marion et al, 1991;Martin et al, 1997;Coles et al, 2002). CBF abnormalities have been shown to be an important mechanism underlying secondary brain damage experimentally (Jenkins et al, 1989;Giri et al, 2000) and clinically have been shown to be strongly associated with poor outcome (Robertson et al, 1992).…”

mentioning

confidence: 99%

Relationship between Flow-Metabolism Uncoupling and Evolving Axonal Injury after Experimental Traumatic Brain Injury

Chen

Richards

Smielewski

et al. 2004

J Cereb Blood Flow Metab

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Summary: Blood flow-metabolism uncoupling is a welldocumented phenomenon after traumatic brain injury, but little is known about the direct consequences for white matter. The aim of this study was to quantitatively assess the topographic interrelationship between local cerebral blood flow (LCBF) and glucose metabolism (LCMRglc) after controlled cortical impact injury and to determine the degree of correspondence with the evolving axonal injury. LCMRglc and LCBF measurements were obtained at 3 hours in the same rat from 18 Ffluorodeoxyglucose and 14 C-iodoantipyrine coregistered autoradiographic images, and compared to the density of damaged axonal profiles in adjacent sections and in an additional group at 24 hours using beta-amyloid precursor protein (ß-APP) immunohistochemistry. LCBF was significantly reduced over the ipsilateral hemisphere by 48 ± 15% compared with shamcontrols, whereas LCMRglc was unaffected, apart from foci of elevated LCMRglc in the contusion margin. Flow-metabolism was uncoupled, indicated by a significant 2-fold elevation in the LCMRglc/LCBF ratio within most ipsilateral structures. There was a significant increase in ß-APP-stained axons from 3 to 24 hours, which was negatively correlated with LCBF and positively correlated with the LCMRglc/LCBF ratio at 3 hours in the cingulum and corpus callosum. Our study indicates a possible dependence of axonal outcome on flow-metabolism in the acute injury stage.

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Early perfusion after controlled cortical impact in rats: Quantification by arterial spin-labeled MRI and the influence of spin-lattice relaxation time heterogeneity

Cited by 63 publications

References 36 publications

Emerging Imaging Tools for Use with Traumatic Brain Injury Research

Emerging Imaging Tools for Use with Traumatic Brain Injury Research

Murine orthostatic response during prolonged vertical studies: Effect on cerebral blood flow measured by arterial spin‐labeled MRI

Relationship between Flow-Metabolism Uncoupling and Evolving Axonal Injury after Experimental Traumatic Brain Injury

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