Early peanut introduction

Koplin, Jennifer J.; McWilliam, Vicki; Soriano, Victoria X.; Peters, Rachel L.

doi:10.1016/j.anai.2023.02.004

Cited by 4 publications

(2 citation statements)

References 65 publications

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“…This was similar to the Singapore report where 89% of participants were introduced to peanuts at the age of 10 months or later. 6,29 On whether infantile peanut introduction should be added to the Japanese Guidelines for Feeding and Weaning, our study provided no evidence that peanuts should be introduced in infancy to prevent PA, because our study showed no clear PA preventive effect of introducing peanuts in infancy. Therefore, these findings suggest that in Japan, it is not the situation to recommend the introduction of peanuts during infancy to prevent the development of PA.…”

Section: Discussionmentioning

confidence: 69%

Infantile Peanut Introduction and Peanut Allergy in Regions With a Low Prevalence of Peanut Allergy: The Japan Environment and Children’s Study (JECS)

Kojima,

Shinohara,

Kushima

et al. 2024

Journal of Epidemiology

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Background: In regions with a high prevalence of peanut allergy (PA), there is a consensus that the introduction of peanuts in early infancy is preventive against the development of PA. However, few studies have investigated whether the introduction of peanuts to infants is associated with PA in regions with a low prevalence of PA, including Japan. Methods: We used data from 74,240 mother-child pairs who participated in the Japan Environment and Children's Study, a prospective birth cohort recruited between January 2011 and March 2014. A logistic regression model was used to analyze the association between infantile peanut introduction and PA at the age of 4 years with non-infantile peanut introduction as the reference group, adjusted for potential confounders. Results: The percentage of infantile peanut introduction was 4.9% (n = 3,294), and 286 (0.4%) participants had allergic symptoms to peanuts at 4 years of age. Of all participants, 129 (0.2%) had PA at 4 years of age, which was defined as allergic symptoms and sensitization to peanuts. Those with infantile peanut introduction had a lower prevalence of PA than those without infantile peanut introduction, although this did not reach statistical significance (adjusted odds ratio 0.53; 95% confidence interval, 0.17-1.68). Sensitivity analysis using IgE-mediated symptoms caused by peanuts as the outcome showed a similar result in relation to infantile peanut introduction. Conclusion:In countries with a low prevalence of PA, the effect of infantile peanut introduction on PA prevention was unclear.

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Section: Discussionmentioning

confidence: 69%

Infantile Peanut Introduction and Peanut Allergy in Regions With a Low Prevalence of Peanut Allergy: The Japan Environment and Children’s Study (JECS)

Kojima,

Shinohara,

Kushima

et al. 2024

Journal of Epidemiology

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“…Accordingly, screening should be limited to cases where eczema cannot be brought into remission early or where parents are too anxious to introduce a food at home. In addition, a system is needed to provide prompt access to oral food challenges to obtain a definitive diagnosis for cases where screening results are positive for sensitization [ 32 ].…”

Section: Screening For Sensitization To Food Antigensmentioning

confidence: 99%

Regular consumption following early introduction of allergenic foods and aggressive treatment of eczema are necessary for preventing the development of food allergy in children

Sakihara

2024

Current Opinion in Allergy &Amp; Clinical Immunology

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Purpose of review Over the past two decades, food allergy prevention strategies have shifted from ‘delayed introduction’ to ‘no delayed introduction’ to ‘early introduction’ of allergenic foods. This article reviews important research in this field published in the early 2020s to support future strategies for food allergy prevention. Recent findings Recent randomized controlled trials (RCTs), systematic reviews, meta-analyses, and real-world studies have reported that early allergenic food introduction, especially peanut and egg, are effective for preventing food allergies. However, there are also reports that food-induced anaphylaxis admission rates in infants are increasing. Summary Early allergenic food introduction by itself is not sufficient to prevent the development of food allergies. Recent RCTs (SPADE study and COMEET study) have demonstrated that continued regular cow's milk consumption after early introduction is important for preventing the onset of cow's milk allergy. Furthermore, an RCT (PACI study) reported that early and aggressive anti-inflammatory topical therapy for eczema can contribute to the prevention of egg allergy by suppressing percutaneous sensitization. Food allergies may be prevented through a combination of early food introduction, regular consumption, and active eczema treatment. Further research is needed to develop well tolerated, effective, and practical strategies to prevent food allergies.

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Overcoming inertia one step at a time

Stukus

2023

Annals of Allergy, Asthma & Immunology

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Early peanut introduction

Cited by 4 publications

References 65 publications

Infantile Peanut Introduction and Peanut Allergy in Regions With a Low Prevalence of Peanut Allergy: The Japan Environment and Children’s Study (JECS)

Infantile Peanut Introduction and Peanut Allergy in Regions With a Low Prevalence of Peanut Allergy: The Japan Environment and Children’s Study (JECS)

Regular consumption following early introduction of allergenic foods and aggressive treatment of eczema are necessary for preventing the development of food allergy in children

Overcoming inertia one step at a time

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