Early Parosmia Signs and Affective States Predict Depression and Anxiety Symptoms 6 Months After a Mild Traumatic Brain Injury

Giguère, Fanny Lecuyer; Jobin, Benoît; Robert, Joëlle; Bastien, Laurianne; Giguère, Jean-François; Beaumont, Louis De; Guise, Élaine de; Frasnelli, Johannes

doi:10.1093/chemse/bjaa037

Cited by 13 publications

(9 citation statements)

References 56 publications

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“…For instance, we clearly show that individuals with parosmia are reminded of their disorder regularly, which has been hypothesized as a reason for greater disruption in daily life (Croy et al, 2013;Frasnelli & Hummel, 2005;Hong et al, 2012b). These patients also report more difficulty adjusting to their disorder, which may explain a recent report showing higher depression and anxiety symptoms in this patient group ( Giguere et al, 2020).…”

Section: Developing a Severity Scoresupporting

confidence: 53%

Prevalence and correlates of parosmia and phantosmia among smell disorders

Pellegrino

Mainland

Kelly³

et al. 2021

Chemical Senses

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Among those many individuals who experience a reduced odor sensitivity (hyposmia/anosmia) some individuals also have disorders that lead to odor distortion, such as parosmia (i.e., distorted odor with a known source), or odor phantoms (i.e., odor sensation without an odor source). We surveyed a large population with at least one olfactory disorder (N = 2031) and found that odor distortions were common (46%), with respondents reporting either parosmia (19%), phantosmia (11%), or both (16%). In comparison to respondents with hyposmia or anosmia, respondents with parosmia were more likely to be female, young, and suffering from post-viral olfactory loss (p < 0.001), while respondents with phantosmia were more likely to be middle-aged (p < 0.01) and experiencing symptoms caused by head trauma (p < 0.01). In addition, parosmia, compared to phantosmia or anosmia/hyposmia, was most prevalent 3 months to a year after olfactory symptom onset (p < 0.001), which coincides with the timeline of physiological recovery. Finally, we observed that the frequency and duration of distortions negatively affects quality of life, with parosmia showing a higher range of severity than phantosmia (p < 0.001). Previous research often grouped these distortions together, but our results show that they have distinct patterns of demographics, medical history, and loss in quality of life.

show abstract

Section: Developing a Severity Scoresupporting

confidence: 53%

Prevalence and correlates of parosmia and phantosmia among smell disorders

Pellegrino

Mainland

Kelly³

et al. 2021

Chemical Senses

View full text Add to dashboard Cite

show abstract

“…For instance, we clearly show that individuals with parosmia are reminded of their disorder regularly, which has been hypothesized as a reason for greater disruption in daily life (Croy et al, 2013; Frasnelli & Hummel, 2005; Hong et al, 2012b). These patients also report more difficulty adjusting to their disorder, which may explain a recent report showing higher depression and anxiety symptoms in this patient group (Lecuyer Giguere et al, 2020).…”

Section: Discussionmentioning

confidence: 73%

Prevalence and Correlates of Parosmia and Phantosmia among Smell Disorders

Pellegrino

Mainland

Kelly³

et al. 2021

Preprint

View full text Add to dashboard Cite

Among those many individuals who suffer from a reduced odor sensitivity (hyposmia/anosmia) some individuals also experience disorders that lead to odor distortion, such as parosmia (i.e., distorted odor with a known source), or odor phantoms (i.e., odor sensation without an odor source). We surveyed a large population with at least one olfactory disorder (N = 2031) and found that odor distortions were common (46%), with respondents reporting either parosmia (19%), phantosmia (11%), or both (16%). In comparison to respondents with hyposmia or anosmia, respondents with parosmia were more likely to be female, young, and suffered from post-viral olfactory loss (p < 0.001), while phantosmia occurred most frequently in middle-aged respondents (p < 0.01) and was more likely to be caused by head trauma than parosmia (p < 0.01). A higher prevalence of odor distortion was observed 3 months to a year after their olfactory symptom onset (p < 0.001), which coincides with the timeline of physiological recovery. Additionally, we observed that the frequency and duration of distortions negatively affects quality of life, with parosmia showing a higher range of severity than phantosmia (p < 0.001). Previous research often grouped these distortions together, but our results show that they have distinct patterns of demographics, medical history, and loss in quality of life.

show abstract

“…For those affected by parosmia, there are limited treatment options and long-term prognosis remains unclear. 1,2 Although studies have suggested a relationship between parosmia and mental health disorders, [3][4][5][6] this relationship has not been thoroughly explored. In this study, we evaluated the association between persistent COVID-mediated parosmia and anxiety, depression, and suicidal ideation (SI).…”

Section: Introductionmentioning

confidence: 99%