Early ovarian ageing: a hypothesis: Detection and clinical relevance

Nikolaou, Dimitrios

doi:10.1093/humrep/deg245

Cited by 160 publications

(100 citation statements)

References 33 publications

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“…In this regard, it is believed that the time passing between the detection of the first signs of reproductive aging and the menopause transition is fixed (van Zonneveld et al 2001, te Velde & Pearson 2002. Thus, ovarian response to hormonal treatments has been proposed as a dynamic test of reproductive aging in women (Nikolaou & Templeton 2003). …”

Section: Follicular Function In Aged Ewesmentioning

confidence: 99%

Effect of aging on follicular function may be relieved by exogenous gonadotropin treatment in a sheep model

Berlinguer

González-Bulnes²,

Spezzigu³

et al. 2012

Reproduction

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The current study investigated hormonal and ovarian changes during physiological reproductive aging in Sarda ewes. In a first experiment, follicular and corpus luteum dynamics were compared during an induced oestrus cycle in aged (12-14 years) and young adult ewes (4-5 years). Oestrus cycle characteristics did not differ between the two experimental groups. However, follicular function during the follicular phase showed significant alterations in aged ewes, as determined by a lack of dominance effect and by lower mean values of circulating oestradiol (E 2 ) and inhibin levels, compared with young adult ewes. In a second experiment, differences in follicle growth, hormonal milieu and oocyte quality in response to exogenous FSH administration were assessed in aged and adult ewes. No differences were recorded in ovarian response to FSH treatment between young adult and aged ewes, as evaluated by ultrasonographic data and circulating concentrations of LH, E 2 and inhibin-A. Although the total number of recovered oocytes was similar in the two age groups, the number of good quality oocytes selected for IVM was significantly lower in aged ewes compared with adult ones. Thereafter, no differences were recorded in cleavage rates, total blastocyst output, embryo developmental kinetic and quality between aged and adult groups. In conclusion, this study demonstrated that reproductive aging in sheep is associated with impaired follicle functionality and an increase in the proportion of oocytes showing morphological abnormalities. However interestingly, oocyte developmental competence in vitro and embryo cryotolerance were not affected by the aging process, when only good quality oocytes were chosen.

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Section: Follicular Function In Aged Ewesmentioning

confidence: 99%

Effect of aging on follicular function may be relieved by exogenous gonadotropin treatment in a sheep model

Berlinguer

González-Bulnes²,

Spezzigu³

et al. 2012

Reproduction

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“…1 000 follikler som forsvinner hver måned (12). Det er vist at alder ved menopause er avhengig av det totale antallet follikler i ovariene og hvor raskt antallet reduseres (13). Kjente risikofaktorer for redusert ovarial reserve, i tillegg til genetiske faktorer, er røy-king, kirurgiske inngrep som affiserer eggstokkene, bekkeninfeksjon, endometriose, kjemoterapi og stråleterapi (13).…”

Section: Ovarial Reserve Og Fruktbarhetunclassified

“…[15][16][17][18][19][20] utvikles hver måned. Av disse vil én dominant follikkel normalt gjennomgå eggløsning av ett modent egg, mens de andre gjennomgår programmert celledød (13,18).…”

Section: Antimüllerhormon Og Folliklerunclassified

Antimüllerhormon ved behandling av ufrivillig barnløshet

Kalra¹

2009

Tidsskriftet

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SammendragBakgrunn. Kvinner i Norge, som i mange andre utviklede land, venter lenger i dag med å få barn enn før. Fruktbarheten hos kvinner synker med alderen, spesielt etter 35 års alder. Det har lenge vaert behov for en bedre markør av ovarial reserve og ovarial respons ved behandling av ufrivillig barnløshet. Denne artikkelen gir en oversikt over fysiologisk utvikling av follikler i eggstokkene og den spesielle plassen antimüllerhormon har i denne prosessen.Materiale og metode. Det ble gjort ikke-systematisk litteratursøk for relevante artikler i PubMed, Athens og Embase.Resultater. Nivået av antimüllerhor-mon er relativt stabilt gjennom menstruasjonssyklusen, og hormonet synes å vaere en pålitelig markør for ovarial respons. Bestemmelse av hormonnivået vil kunne identifisere kvinner med høy risiko for avvikende respons ved ovarial stimulering.Fortolkning. Klinisk bruk av antimül-lerhormon er først og fremst aktuelt ved utredning og behandling av ufrivillig barnløshet.

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“…Despite an earlier age of menopause, most affected patients will not meet the definition for POI, yet some may become menopausal before the age of 45 years old. POI affects 1 % of women, whereas DOR affects a much larger portion of the infertile population [9][10][11][15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%