Early Outcome After Lung Transplantation From Non–Heart-Beating Donors is Comparable to Heart-Beating Donors

Vleeschauwer, Stéphanie De; Raemdonck, Dirk Van; Vanaudenaerde, Bart M.; Vos, Robin; Meers, Caroline Marie F; Wauters, Shana; Coosemans, Willy; Decaluwé, Herbert; Leyn, Paul De; Nafteux, Philippe; Dupont, Lieven; Lerut, Toni; Verleden, Geert M.

doi:10.1016/j.healun.2009.01.010

Cited by 55 publications

(33 citation statements)

References 41 publications

(30 reference statements)

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“…Thus, in our approach, a standard DCD3 donor with a PaO 2 /FiO 2 ratio >40 kPa, an agonal phase of 90 min or less, and after immediate restart of ventilation at arrival on the operating room, is not marginal and can be transplanted without EVLP. In the short-term period, posttransplant lung function seems to be at least as good in DCD3 compared to DBD (3,5,6,11,21). As Mason et al noticed before, the native lung may be influencing the lung function after SLTx (22).…”

Section: Discussionmentioning

confidence: 90%

A Multicenter Study on Long-Term Outcomes After Lung Transplantation Comparing Donation After Circulatory Death and Donation After Brain Death

Suylen

Luijk

Hoek

et al. 2017

American Journal of Transplantation

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The implementation of donation after circulatory death category 3 (DCD3) was one of the attempts to reduce the gap between supply and demand of donor lungs. In the Netherlands, the total number of potential lung donors was greatly increased by the availability of DCD3 lungs in addition to the initial standard use of donation after brain death (DBD) lungs. From the three lung transplant centers in the Netherlands, 130 DCD3 recipients were one-to-one nearest neighbor propensity score matched with 130 DBD recipients. The primary end points were primary graft dysfunction (PGD), posttransplant lung function, freedom from chronic lung allograft dysfunction (CLAD), and overall survival. PGD did not differ between the groups. Posttransplant lung function was comparable after bilateral lung transplantation, but seemed worse after DCD3 single lung transplantation. The incidence of CLAD (p = 0.17) nor the freedom from CLAD (p = 0.36) nor the overall survival (p = 0.40) were significantly different between both groups. The presented multicenter results are derived from a national context where one third of the lung transplantations are performed with DCD3 lungs. We conclude that the long-term outcome after lung transplantation with DCD3 donors is similar to that of DBD donors and that DCD3 donation can substantially enlarge the donor pool.Abbreviations: BLTx, bilateral lung transplantation(s); BOS, bronchiolitis obliterans syndrome; CIT, cold ischemic time; CLAD, chronic lung allograft dysfunction; CMV, cytomegalovirus; DBD, donation after brain death; DCD3, donation after circulatory death category 3; EVLP, ex-vivo lung perfusion; FEV 1 %, forced expiratory volume in 1 s as a percentage of predicted; FEV 1 , forced expiratory volume in 1 s; FiO 2 , fraction of inspired oxygen; FVC%, forced vital capacity as a percentage of predicted; FVC, forced vital capacity; ICU, intensive care unit; PaO 2 , arterial oxygen pressure; PEEP, positive end expiratory pressure;

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Section: Discussionmentioning

confidence: 90%

A Multicenter Study on Long-Term Outcomes After Lung Transplantation Comparing Donation After Circulatory Death and Donation After Brain Death

Suylen

Luijk

Hoek

et al. 2017

American Journal of Transplantation

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“…19 Briefly, donors were selected according standard ISHLT criteria 20 and the same criteria regarding age, gas exchange, chest X-ray appearance, bronchoscopy findings and smoking history were considered. This information was also available from these controlled DCDs (Maastricht Category III) in the hours prior to organ recovery.…”

Section: Methodsmentioning

confidence: 99%

“…[12][13][14][15][16][17][18] Our group has previously reported an initial experience with early outcomes in 5 DCD lung recipients. 19 In this study we review our experience over the last 4 years with a cohort of 21 patients and report on their immediate post-operative and medium-term (Ͼ1 year) outcomes.…”

mentioning

confidence: 99%

Medium-term outcome after lung transplantation is comparable between brain-dead and cardiac-dead donors

Vleeschauwer

Wauters

Dupont

et al. 2011

The Journal of Heart and Lung Transplantation

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“…Tolerable WIT, defined as the time between cardiac arrest and cold flush, is around 30 minutes (5,7,(10)(11)(12)17,(19)(20)(21)(22)(23)(24)(25)(26)28,59,60,63,64). However, based on experimental data WIT of 60 minutes is tolerable (1,7).…”

Section: Donor Selection Criteria Cdcd Donorsmentioning

confidence: 99%

“…A recent International Society for Heart and Lung Transplantation (ISHLT) DCD Registry Report included 306 recipients among ten centers worldwide (12). Several centers published their experience, most of them with excellent or at least equal results compared to brain-dead donors (5,14,(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28).…”

Section: Introductionmentioning

confidence: 99%

Donors after cardiocirculatory death and lung transplantation

İnci

2017

J. Thorac. Dis.

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Abstract:The number of patients actively awaiting lung transplantation (LTx) is more than the number of suitable donor lungs. The percentage of lung retrieval rate is lower when compared to other solid organs.The use of lungs from donation after cardiocirculatory death (DCD) donors is one of the options to avoid organ shortage in LTx. After extensive experimental research, clinical application of DCD donation is becoming wider. The results from most of the centers show at least equal survival rate compared to donors from brain death. This review paper will summarize experimental background and clinical experience from DCD donors.

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Early Outcome After Lung Transplantation From Non–Heart-Beating Donors is Comparable to Heart-Beating Donors

Cited by 55 publications

References 41 publications

A Multicenter Study on Long-Term Outcomes After Lung Transplantation Comparing Donation After Circulatory Death and Donation After Brain Death

A Multicenter Study on Long-Term Outcomes After Lung Transplantation Comparing Donation After Circulatory Death and Donation After Brain Death

Medium-term outcome after lung transplantation is comparable between brain-dead and cardiac-dead donors

Donors after cardiocirculatory death and lung transplantation

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