Early osteoarthritis: How to define, diagnose, and manage. A systematic review

Iolascon, Giovanni; Gimigliano, Francesca; Moretti, Antimo; Sire, Alessandro de; Migliore, Alberto; Brandi, Maria Luisa; Piscitelli, Pamela

doi:10.1016/j.eurger.2017.07.008

Cited by 43 publications

(34 citation statements)

References 142 publications

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“…OA mainly targets the hip and knee joints, although other skeletal sites (i.e., hands, feet, spine) might be affected by this condition [2]. In particular, knee OA has a prevalence of 3.8% and an incidence of 12% in the elderly population and occurs with joint pain and peri-articular muscle weakness with a subsequent loss of function, increased disability, and reduction of health-related quality of life [3,4]. Indeed, an early diagnosis of OA is crucial to set up a prompt, effective, and patient-oriented treatment in order to prevent the age-related degenerative progression of this pathological condition [5].…”

Section: Introductionmentioning

confidence: 99%

Gut–Joint Axis: The Role of Physical Exercise on Gut Microbiota Modulation in Older People with Osteoarthritis

Sire

Petito

et al. 2020

Nutrients

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Osteoarthritis (OA) is considered one of the most common joint disorders worldwide and its prevalence is constantly increasing due to the global longevity and changes in eating habits and lifestyle. In this context, the role of gut microbiota (GM) in the pathogenesis of OA is still unclear. Perturbation of GM biodiversity and function, defined as ‘gut dysbiosis’, might be involved in the development of inflammaging, one of the main risk factors of OA development. It is well known that physical exercise could play a key role in the prevention and treatment of several chronic diseases including OA, and it is recommended by several guidelines as a first line intervention. Several studies have shown that physical exercise could modulate GM composition, boosting intestinal mucosal immunity, increasing the Bacteroidetes–Firmicutes ratio, modifying the bile acid profile, and improving the production of short chain fatty acids. Moreover, it has been shown that low intensity exercise might reduce the risk of gastrointestinal diseases, confirming the hypothesis of a strict correlation between skeletal muscle and GM. However, up to date, there is still a lack of clinical trials focusing on this research field. Therefore, in this narrative, we aimed to summarize the state-of-the-art of the literature regarding the correlation between these conditions, supporting the hypothesis of a ‘gut–joint axis’ and highlighting the role of physical exercise combined with adequate diet and probiotic supplements in rebalancing microbial dysbiosis.

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Section: Introductionmentioning

confidence: 99%

Gut–Joint Axis: The Role of Physical Exercise on Gut Microbiota Modulation in Older People with Osteoarthritis

Sire

Petito

et al. 2020

Nutrients

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“…The diagnosis of OA primarily consists of physical examination and radiographic findings, which can only be used in diagnosis at later stages of OA, but not for early diagnosis [ 6 ]. Early diagnosis is crucial for better and more effective application of conservative and modern therapeutic approaches (stem cell-based) to prevent or delay disease progression [ 7 ]. The conservative therapeutic approaches such as physical exercise, vibration, oxygen-ozone therapy, and hyaluronic acid are effective if OA is diagnosed early [ 8 , 9 , 10 , 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Sex-Specific Differences in Extracellular Vesicle Protein Cargo in Synovial Fluid of Patients with Osteoarthritis

Kolhe

Owens

Sharma

et al. 2020

Life

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Women are at a significantly higher risk of developing osteoarthritis (OA) compared to males. The pathogenesis of osteoarthritis (OA) in women is poorly understood. Extracellular vesicles (EVs) have been shown to play an essential role in numerous signaling processes during the pathogenesis of age-related diseases via paracrine signaling. Molecular profiling of the synovial fluid-derived EVs cargo in women may help in the discovery of novel biomarkers and therapeutics for the treatment of OA in women. Previously, we reported that synovial fluid-derived EV miRNA cargo differs in a sex-specific manner. This study aims to characterize synovial fluid-derived EV protein cargo in OA patients. Our data showed sex-specific EVs protein content in OA. We found haptoglobin, orosomucoid, and ceruloplasmin significantly up-regulated, whereas apolipoprotein down-regulated in female OA EVs. In males, we discovered β-2-glycoprotein, and complement component 5 proteins significantly up-regulated and Spt-Ada-Gcn5 acetyltransferase (SAGA)-associated factor 29 down-regulated in male OA EVs. Database for Annotation, Visualization, and Integrated Discovery (DAVID) and QuickGO analysis revealed OA-specific protein involvement in several biological, molecular, and cellular pathways, specifically in inflammatory processes. In conclusion, synovial fluid EV protein content is altered in a sex-specific manner with OA, explaining the increased prevalence and severity of OA in women.

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“…Since articular cartilage alterations are one of the hallmarks of knee OA development (Eckstein et al, 2006), an assessment of cartilage morphology is considered a key outcome in defining early knee OA (Favero et al, 2015; Iolascon et al, 2017; Madry et al, 2016; Pollard et al, 2008). Unlike advanced-stage knee OA that is characterized by a loss of articular cartilage, early knee OA is often characterized by both thinning and thickening of cartilage at various spatial locations within the tibiofemoral joint (Buck et al, 2012; Buck et al, 2013; Buck et al, 2010; Favre et al, 2017; Favre et al, 2013; Wirth et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Diffuse tibiofemoral cartilage change prior to the development of accelerated knee osteoarthritis: Data from the osteoarthritis initiative

et al. 2018

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Introduction: We compared the spatial distribution of tibiofemoral cartilage change between individuals who will develop accelerated knee osteoarthritis (KOA) versus typical onset of KOA prior to the development of radiographic KOA. Materials and Methods: We conducted a longitudinal case-control analysis of 129 individuals from the Osteoarthritis Initiative. We assessed the percent change in tibiofemoral cartilage on magnetic resonance images at 36 informative locations from two to one year prior to the development of accelerated (n=44) versus typical KOA (n=40). We defined cartilage change in the accelerated and typical KOA groups at 36 informative locations based on thresholds of cartilage percent change in a no KOA group (n=45). We described the spatial patterns of cartilage change in the accelerated KOA and typical KOA groups and performed a logistic regression to determine if diffuse cartilage change (predictor; at least half of the tibiofemoral regions demonstrating change in multiple informative locations) was associated with KOA group (outcome). Results: There was a non-significant trend that individuals with diffuse tibiofemoral cartilage change were 2.2 times more likely to develop accelerated knee OA when compared to individuals who develop typical knee OA (OR [95% CI] = 2.2 [0.90,5.14]. Adults with accelerated or typical KOA demonstrate heterogeneity in spatial distribution of cartilage thinning and thickening. Conclusions: These results provide preliminary evidence of a different spatial pattern of cartilage change between individuals that will develop accelerated versus typical KOA. These data suggest there may be different mechanisms driving the early structural disease progression between accelerated versus typical KOA.

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Early osteoarthritis: How to define, diagnose, and manage. A systematic review

Cited by 43 publications

References 142 publications

Gut–Joint Axis: The Role of Physical Exercise on Gut Microbiota Modulation in Older People with Osteoarthritis

Gut–Joint Axis: The Role of Physical Exercise on Gut Microbiota Modulation in Older People with Osteoarthritis

Sex-Specific Differences in Extracellular Vesicle Protein Cargo in Synovial Fluid of Patients with Osteoarthritis

Diffuse tibiofemoral cartilage change prior to the development of accelerated knee osteoarthritis: Data from the osteoarthritis initiative

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