Early Oral Feeding After Surgery for Upper Gastrointestinal Malignancies: A Prospective Cohort Study

Shoar, Saeed; Naderan, Mohammad; Mahmoodzadeh, Habibollah; Hosseini-Araghi, Negin; Mahboobi, Nastaran; Sirati, Fereidoon; Khorgami, Zhamak

doi:10.5001/omj.2016.36

Cited by 15 publications

(23 citation statements)

References 22 publications

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“…Seven of the 15 studies were randomised control trials, [17][18][19][20][21][22][23] six studies were cohort studies [24][25][26][27][28][29] and two were non-randomised trials. 30,31 The study by Hur et al 31 was a pilot to a larger study; 19 however, both were included in this review because they included different participant cohorts. The 15 studies included a total of 2517 participants.…”

Section: Overview Of Included Studiesmentioning

confidence: 99%

“…Comparator groups included historical cohorts in five studies 24,[26][27][28][29] receiving usual care as defined by the authors and concurrent controls in the remaining 10 studies. [17][18][19][20][21][22][23]25,30 Within the included studies, sample size ranged between 34 and 552 participants. Out of the 15 studies, 10 [17][18][19][20]23,[25][26][27]29,31 examined patients with gastric cancer, undergoing partial and/or total gastrectomy.…”

Section: Overview Of Included Studiesmentioning

confidence: 99%

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Early postoperative feeding following surgery for upper gastrointestinal cancer: A systematic review

Carmichael

Rocca

Laing

et al. 2021

J Human Nutrition Diet

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I N TRODUC TIONUpper gastrointestinal (UGI) cancers, specifically oesophageal and gastric cancers, account for almost 10% of new cancer cases globally and approximately 13% of cancer mortality. 1 Surgical resection, with or without neoadjuvant and adjuvant therapies, remains the basis of curative intent treatment for this cancer group. These procedures are significant and not without a high risk of complications, such as anastomotic leak and impacts on morbidity, mortality and quality of life (QOL), which are of significant concern to medical teams. [2][3][4][5] Post major UGI surgery, enteral or parenteral nutrition or the timing or type of oral diet, is a significant consideration known to affect postoperative recovery and the ability to tolerate adjuvant treatment. 5 Despite its importance, there

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Section: Overview Of Included Studiesmentioning

confidence: 99%

Section: Overview Of Included Studiesmentioning

confidence: 99%

Early postoperative feeding following surgery for upper gastrointestinal cancer: A systematic review

Carmichael

Rocca

Laing

et al. 2021

J Human Nutrition Diet

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“…Malnutrition actually worsens upon the inclusion of the different treatments (chemotherapy, radiotherapy and operation), further worsening the patient’s general condition. It is paramount that adequate nutritional needs be met before, during and after treatment 13 .…”

Section: Introductionmentioning

confidence: 99%

Early Oral Feeding Post-Upper Gastrointestinal Tract Resection and Primary Anastomosis in Oncology

Lopes¹,

Menezes²,

Toledo

et al. 2018

ABCD, arq. bras. cir. dig.

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Background: The practice of starving patients in the immediate period after upper gastrointestinal surgery is widespread. Early oral intake has been shown to be feasible and may result in faster recovery and decrease length of hospital. Aim:To evaluate the feasibility and safety of oral nutrition on postoperative early feeding after upper gastrointestinal surgeries. Methods: Observational cohort design study with convenience retrospective data in both genders, over 18 years, undergoing to total gastrectomy and/or elective esophagectomy. They have received oral or enteral nutrition in less than 48 h after surgery, and among those who started with enteral nutrition, the oral feeding up to seven days. Results: The study was performed in 161 patients, 24 (14.9%) submitted to esophagectomy, 132 (82%) to total gastrectomy and five (3.1%) to esophagogastrectomy. Was observed good dietary acceptance and low percentage (29%) of gastrointestinal intolerances, more pronounced among those with enteral diet. Most of the patients did not present postoperative complications, 11 (6.8%) were reopened, five (3.1%) had fistulas, three (1.9%) wound dehiscence, three (1.9%) fistula more wound dehiscence and six (3.7%) other non-infectious complications. Conclusion: Early oral diet is safe and viable for patients undergoing upper gastrointestinal surgery.

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“…So far, there have been studies showing that patients who underwent gastrectomy can be supported by early postoperative enteral nutrition[ 3 - 5 ]. Moreover, Shoar et al[ 20 ] showed that for patients with upper gastrointestinal malignant tumors, EOF after surgery can lead to faster recovery and shorter postoperative hospitalization. Lopes et al[ 21 ] also indicated that early oral diet was safe and viable for patients undergoing upper gastrointestinal surgery.…”

Section: Discussionmentioning

confidence: 99%

Effects of early oral feeding after radical total gastrectomy in gastric cancer patients

Lu¹,

Wang²,

Xie³

et al. 2020

WJG

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BACKGROUND Gastric cancer (GC) is a heavy burden in China. Nutritional support for GC patients is closely related to postoperative rehabilitation. However, the role of early oral feeding after laparoscopic radical total gastrectomy in GC patients is unclear and high-quality research evidence is scarce. AIM To prospectively explore the safety, feasibility and short-term clinical outcomes of early oral feeding after laparoscopic radical total gastrectomy for GC patients. METHODS This study was a prospective cohort study conducted between January 2018 and December 2019 based in a high-volume tertiary hospital in China. A total of 206 patients who underwent laparoscopic radical total gastrectomy for GC were enrolled. Of which, 105 patients were given early oral feeding (EOF group) after surgery, and the other 101 patients were given the traditional feeding strategy (control group) after surgery. Perioperative clinical data were recorded and analyzed. The primary endpoints were gastrointestinal function recovery time and postoperative complications, and the secondary endpoints were postoperative nutritional status, length of hospital stay and expenses, etc . RESULTS Compared with the control group, patients in the EOF group had a significantly shorter postoperative first exhaust time (2.48 ± 1.17 d vs 3.37 ± 1.42 d, P = 0.001) and first defecation time (3.83 ± 2.41 d vs 5.32 ± 2.70 d, P = 0. 004). In addition, the EOF group had a significant shorter postoperative hospitalization duration (5.85 ± 1.53 d vs 7.71 ± 1.56 d, P < 0.001) and lower postoperative hospitalization expenses (16.60 ± 5.10 K¥ vs 21.00 ± 7.50 K¥, P = 0.014). On the 5 th day after surgery, serum prealbumin level (214.52 ± 22.47 mg/L vs 204.17 ± 20.62 mg/L, P = 0.018), serum gastrin level (246.30 ± 57.10 ng/L vs 223.60 ± 55.70 ng/L, P = 0.001) and serum motilin level (424.60 ± 68.30 ng/L vs 409.30 ± 61.70 ng/L, P = 0.002) were higher in the EOF group. However, there was no significant difference in the incidence of total postoperative complications between the two groups ( P = 0.507). CONCLUSION Early oral feeding after laparoscopic radical total gastrectomy can promote the recovery of gastrointestinal function, improve postoperative nutritional status, reduce length of hospital stay and expenses while not increasing the incidence of related complications, which indicates its safety, feasibility and potential benefits for gastric cancer patients.

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Early Oral Feeding After Surgery for Upper Gastrointestinal Malignancies: A Prospective Cohort Study

Abstract: EOF is safe following esophageal and gastric cancer surgery and results in faster recovery and hospital discharge.

Cited by 15 publications

References 22 publications

Early postoperative feeding following surgery for upper gastrointestinal cancer: A systematic review

Early postoperative feeding following surgery for upper gastrointestinal cancer: A systematic review

Early Oral Feeding Post-Upper Gastrointestinal Tract Resection and Primary Anastomosis in Oncology

Effects of early oral feeding after radical total gastrectomy in gastric cancer patients

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