Early-onset severe isoniazid-induced motordominant neuropathy: a case report

Zaoui, A.; Abdelghani, A.; Salem, H. Ben; Ouanes, W.; Hayouni, A.; Khachnaoui, F.; Rejeb, N.; Benzarti, M

doi:10.26719/2012.18.3.298

Cited by 9 publications

(7 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Motor neurons, and in particular those which feed more distal muscles, appear most affected by this process, which leads to an increasing denervation of muscle fibres ( 146 ) . These findings are consistent with case studies of isoniazid (isonicotinic acid hydrazide, a vitamin B 6 antagonist) toxicity in humans, in which motor symptoms are reportedly predominant ( 140 ) . Interestingly, however, the morphological changes discussed earlier have been shown to be present in cases without any clinical signs of neuromuscular dysfunction.…”

Section: Pyridoxine (Vitamin B6)supporting

confidence: 87%

“…Clinical indicators of marked PD in adults are largely neurological and epithelial/mucosal aberrations, which mimic deficiency of other vitamins within the B complex. The majority of neurological symptoms (particularly in cases of mild PD, which is more commonplace) appear to affect the peripheral nervous system (PNS) and are associated with loss of motor function ( 140 ) . These include numbness/paresthesia in the extremities which may progress to a loss of distal sensation, motor ataxia, weakness and loss of deep tendon reflexes ( 141 – 143 ) .…”

Section: Pyridoxine (Vitamin B6)mentioning

confidence: 99%

See 1 more Smart Citation

Selected B vitamins and their possible link to the aetiology of age-related sarcopenia: relevance of UK dietary recommendations

2018

View full text Add to dashboard Cite

The possible roles of selected B vitamins in the development and progression of sarcopenia are reviewed. Age-related declines in muscle mass and function are associated with huge and increasing costs to healthcare providers. Falls and loss of mobility and independence due to declining muscle mass/function are associated with poor clinical outcomes and their prevention and management are attractive research targets. Nutritional status appears a key modifiable and affordable intervention. There is emerging evidence of sarcopenia being the result not only of diminished anabolic activity but also of declining neurological integrity in older age, which is emerging as an important aspect of the development of age-related decline in muscle mass/function. In this connection, several B vitamins can be viewed as not only cofactors in muscle synthetic processes, but also as neurotrophic agents with involvements in both bioenergetic and trophic pathways. The B vitamins thus selected are examined with respect to their relevance to multiple aspects of neuromuscular function and evidence is considered that requirements, intakes or absorption may be altered in the elderly. In addition, the evidence base for recommended intakes (UK recommended daily allowance) is examined with particular reference to original datasets and their relevance to older individuals. It is possible that inconsistencies in the literature with respect to the nutritional management of sarcopenia may, in part at least, be the result of compromised micronutrient status in some study participants. It is suggested that in order, for example, for intervention with amino acids to be successful, underlying micronutrient deficiencies must first be addressed/eliminated.

show abstract

Section: Pyridoxine (Vitamin B6)supporting

confidence: 87%

Section: Pyridoxine (Vitamin B6)mentioning

confidence: 99%

Selected B vitamins and their possible link to the aetiology of age-related sarcopenia: relevance of UK dietary recommendations

2018

View full text Add to dashboard Cite

show abstract

“…Results from this study shows that the prevalence of PN in HIV positive children attending CTC at MNH was 14.1 %. The prevalence of HIV associated PN in children varies greatly among studies from different countries ranging from 13 to 34 % [ 10 – 13 ]. The prevalence from this study was consistent with a study done in HIV positive Peruvian children who were diagnosed using electrophysiological tests [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

“…There was a significant association between the use ARTregimethat contained NRTI’s plus PI’s with PN. Previous studies have shown that some of the NRTI’s can cause PN in both adults and children, particularly the dideoxy-NRTI’s (d – drugs) like stavudine, didanosine, and zalcitabine which are known to cause mitochondrial damage in the peripheral nerves [ 13 , 24 , 25 ]. These drugs have been phased out from the ART regimens for both children and adults living with HIV, and none of the participants in our study were using ART regime containing d-drugs.…”

Section: Discussionmentioning

confidence: 99%

Peripheral neuropathy in HIV-infected children attending care and treatment clinic, at Muhimbili National Hospital, Dar es Salaam: a cross sectional study

et al. 2021

View full text Add to dashboard Cite

Background Peripheral neuropathy (PN) is a neurological complication of untreated Human Immunodeficiency Virus (HIV) infection or exposure to certain antiretroviral drugs. In Tanzania where HIV is a major public health problem, the burden of HIV associated peripheral neuropathy has not yet been well defined in children.Thisstudy investigated the prevalence and associated factors for peripheral neuropathy among children living with HIV, attending Care and Treatment Clinic (CTC) at Muhimbili National Hospital (MNH). Materials and methods A cross-sectional study was conducted among 383 HIV positive children aged 5 to 18 years at MNH, CTC in Dar es Salaam between October to December 2019. All participants provided written assent/consent. Structured questionnaires designed for this study was used to collect data and screening for peripheral neuropathy was done on each participant using the Pediatric modified Total Neuropathy Score (Ped m TNS) that includes subjective and objective assessment. A score of 5 or greater on the Ped m TNS was used to define peripheral neuropathy. Data analysis was done using SPSS Version 23. Results The prevalence of peripheral neuropathy among HIV infected children was 14.1 % (95 % CI (10.8 − 18 %). Common neuropathic symptoms were numbness, tingling sensation, reduced ankle reflexes and reduced sensation to light touch and pain that was limited to the toes. Low CD4 cell count (OR = 12.21; 95 % CI3.75–39.66; p = 0.0001), high viral load (OR = 10.54; 95 % CI 3.19–34.77; p = 0.0001), ART regime containing NRTI plus PI (OR = 3.93; 95 % CI 1.43– 10.74; p = 0.01) and the last exposure to isoniazid more than 6 months ago (OR = 3.71; 95 % CI 1.57–8.77; p = 0.003) were independent predictors for peripheral neuropathy. Conclusion Peripheral neuropathy is common among HIV infected children attending CTC at MNH and its frequency increases with advanced disease. The choice of ART regimen and other drugs for treating comorbid conditions should carefully be evaluated.

show abstract

“…Isoniazid can cause peripheral neuropathy but weakness is not a common side effect of isoniazid. There is a prior case report of motor-dominant neuropathy related to isoniazid 5. However, the adverse effect is dose related and the symptoms should be reversible within the first few weeks after isoniazid discontinuation.…”

Section: Discussionmentioning

confidence: 99%

A slow progressor HIV-infected boy developing quadriplegia with evidence of Epstein-Barr virus associated smooth muscle tumour of the cervical spinal cord

et al. 2015

View full text Add to dashboard Cite

show abstract

Early-onset severe isoniazid-induced motordominant neuropathy: a case report

Cited by 9 publications

References 8 publications

Selected B vitamins and their possible link to the aetiology of age-related sarcopenia: relevance of UK dietary recommendations

Selected B vitamins and their possible link to the aetiology of age-related sarcopenia: relevance of UK dietary recommendations

Peripheral neuropathy in HIV-infected children attending care and treatment clinic, at Muhimbili National Hospital, Dar es Salaam: a cross sectional study

A slow progressor HIV-infected boy developing quadriplegia with evidence of Epstein-Barr virus associated smooth muscle tumour of the cervical spinal cord

Contact Info

Product

Resources

About