Early-onset sepsis in term infants admitted to neonatal intensive care units (2011–2016)

Polcwiartek, Laura Bech; Smith, P. Brian; Benjamin, Daniel K.; Zimmerman, Kanecia O.; Love, Alycia; Tiu, Lance; Murray, Sylvia; Kang, Phillip H.; Ebbesen, Finn; Hagstrøm, Søren; Clark, Reese H.; Greenberg, Rachel G.

doi:10.1038/s41372-020-00860-3

Cited by 22 publications

(15 citation statements)

References 25 publications

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“…A lower Apgar score in new-borns with EOS is reported by others. 18 , 19 Some isoforms of apelin, such as APLN-13 and APLN-36 inhibit ROS, and improve the oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

Role of Serum Apelin in the Diagnosis of Early-Onset Neonatal Sepsis

ELMeneza¹,

Bagoury²,

Mohamed³

2021

Turk Arch Pediatrics

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Objective: Apelin is a proinflammatory adipocyte-derived factor. The aim of this study was to evaluate the role and significance of serum apelin as a new sepsis marker in the identification of full-term and preterm new-born infants with early-onset sepsis. Material and Methods: This was a case-control study. We included 80 neonates. The cases were divided into 2 groups; neonates with early-onset sepsis and control group with neonates non-sepsis. Apelin was quantified by enzyme-linked immunosorbent assay. Results: There was a significant elevation in the mean values of serum apelin in the early-onset sepsis group (1214.7 ± 273.06 pg/mmol) than in the non-septic neonates 116.27 ± 21.96 pg/mmol ( P < .0001). Apelin values were correlated to clinical sepsis and hematological scores as well as C-reactive protein. Serum apelin concentration was significantly higher among culture-positive cases than the culture-negative cases (mean ± SD was 1239.52 ± 268.47 and 929.42 ± 136.97 pg/mmol, respectively, P < .0001). Moreover, the apelin level was higher in non-survivor neonates than in the survivors in the early-onset sepsis group. No significant difference was found between preterm and full-term new-born infants with regard to the apelin values. The best cut-off estimate of apelin to diagnose early sepsis was >178.33 pg/mmol. Conclusion: Apelin may be useful in the diagnosis and prognostic prediction of neonates with early-onset sepsis.

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“…A lower Apgar score in new-borns with EOS is reported by others. 18 , 19 Some isoforms of apelin, such as APLN-13 and APLN-36 inhibit ROS, and improve the oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

Role of Serum Apelin in the Diagnosis of Early-Onset Neonatal Sepsis

ELMeneza¹,

Bagoury²,

Mohamed³

2021

Turk Arch Pediatrics

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“…Public health recommendations for the prevention GBS-EOD were launched 25 years ago. Nevertheless, GBS continues to be one of the most frequent organism causing earlyonset sepsis in both developing and developed countries [6,[34][35][36]. In the Netherlands and the UK, the incidence of GBS-EOD is even increased [37,38] despite the introduction of national prevention guidelines.…”

Section: Preventionmentioning

confidence: 99%

Invasive Group B Streptococcal Disease in Neonates and Infants, Italy, Years 2015–2019

et al. 2021

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Invasive infections by group B streptococci (iGBS) are the leading cause of sepsis and meningitis in the first three months of life worldwide. The clinical and microbiological characteristics of neonatal and infant iGBS in Italy during the years 2015–2019 were investigated. Voluntary-based surveillance reported 191 cases (67 early-onset (EOD) and 124 late-onset disease (LOD)) and 89 bacterial isolates were received. The main clinical manifestations were sepsis (59.2%) followed by meningitis (21.5%), bacteremia (12.0%) and septic shock (6.3%). Hospitalized preterm babies accounted for one third of iGBS and constituted the most fragile population in terms of mortality (8.2%) and brain damage (16.4%). GBS serotype III was predominant in EOD (56%) and caused almost all LOD (95%). The rate of resistance to clindamycin reached 28.8%. Most of clindamycin-resistant GBS strains (76%) were serotype III-ST17 and possessed the genetic markers of the emerging multidrug resistant (MDR) CC-17 sub-clone. Our data revealed that iGBS is changing since it is increasingly reported as a healthcare-associated infection (22.6%), mainly caused by MDR-CC17. Continuous monitoring of the clinical and microbiological characteristics of iGBS remains of primary importance and it represents, at present, the most effective tool to support prevention strategies and the research on the developing GBS vaccine.

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“…In term neonates much lower mortalities were found. In a cohort of more than 140,000 term infants mortality was 0.8% in infants with EOS vs. 0.2% in those without ( 16 ).…”

Section: Introductionmentioning

confidence: 96%

Diagnosis of Neonatal Sepsis: The Role of Inflammatory Markers

Eichberger

Resch

2022

Front. Pediatr.

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This is a narrative review on the role of biomarkers in the diagnosis of neonatal sepsis. We describe the difficulties to obtain standardized definitions in neonatal sepsis and discuss the limitations of published evidence of cut-off values and their sensitivities and specificities. Maternal risk factors influence the results of inflammatory markers as do gestational age, the time of sampling, the use of either cord blood or neonatal peripheral blood, and some non-infectious causes. Current evidence suggests that the use of promising diagnostic markers such as CD11b, CD64, IL-6, IL-8, PCT, and CRP, either alone or in combination, might enable clinicians discontinuing antibiotics confidently within 24–48 h. However, none of the current diagnostic markers is sensitive and specific enough to support the decision of withholding antibiotic treatment without considering clinical findings. It therefore seems to be justified that antibiotics are often initiated in ill term and especially preterm infants. Early markers like IL-6 and later markers like CRP are helpful in the diagnosis of neonatal sepsis considering the clinical aspect of the neonate, the gestational age, maternal risk factors and the time (age of the neonate regarding early-onset sepsis) of blood sampling.

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Early-onset sepsis in term infants admitted to neonatal intensive care units (2011–2016)

Cited by 22 publications

References 25 publications

Role of Serum Apelin in the Diagnosis of Early-Onset Neonatal Sepsis

Role of Serum Apelin in the Diagnosis of Early-Onset Neonatal Sepsis

Invasive Group B Streptococcal Disease in Neonates and Infants, Italy, Years 2015–2019

Diagnosis of Neonatal Sepsis: The Role of Inflammatory Markers

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